10.1002/ajmg.1320460428.abs We have performed linkage analysis is a small family with autosomal dominant inheritance of multiple café‐au‐lait spots (CLS) in order to clarify its relationship to classical von Recklinghausen disease (NF 1). We found that an affected woman had transmitted a different haplotype for markers flanking the NF 1 gene to both of her affected daughters. These results exclude an allelic mutation of the NF 1 gene on chromosome 17 as the cause for inherited café‐au‐lait spots in this family. © 1993 Wiley‐Liss, Inc.
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