Access the full text.
Sign up today, get DeepDyve free for 14 days.
Jian Xu, A. Beyer, W. Walker, E. Mcgee (2003)
Developmental and stage-specific expression of Smad2 and Smad3 in rat testis.Journal of andrology, 24 2
Roberto MantovaniS, Xiaoyan Li, Ulrich Pessaran, Robert, van Huisjduijnenll, C. Benoist, D. Mathis (1994)
Dominant negative analogs of NF-YA.The Journal of biological chemistry, 269 32
(1988)
The cytology of the testis
G. Waeber, T. Meyer, M. Lesieur, H. Hermann, N. Gérard, J Habener (1993)
Developmental stage-specific expression of cyclic adenosine 3',5'-monophosphate response element binding protein CREB during spermatogenesis involves alternative exon splicing.Molecular endocrinology, 7 11
F. Nantel, L. Monaco, N. Foulkes, D. Masquilier, M. Lemeur, K. Henriksén, A. Dierich, M. Parvinen, P. Sassone-Corsi (1996)
Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant miceNature, 380
W. Lui, Will Lee (2006)
Regulation of junction dynamics in the testis—Transcriptional and post-translational regulations of cell junction proteinsMolecular and Cellular Endocrinology, 250
J. Blendy, K. Kaestner, G. Weinbauer, E. Nieschlag, G. Schütz (1996)
Severe impairment of permatogenesis in mice lacking the CREM geneNature, 380
L. Russell (1977)
Movement of spermatocytes from the basal to the adluminal compartment of the rat testis.The American journal of anatomy, 148 3
W. Lui, Will Lee (2005)
cAMP perturbs inter‐sertoli tight junction permeability barrier in vitro via its effect on proteasome‐sensitive ubiquitination of occludinJournal of Cellular Physiology, 203
M. Scobey, S. Bertera, J. Somers, Simon Watkins, A. Zeleznik, W. Walker (2001)
Delivery of a Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein (CREB) Mutant to Seminiferous Tubules Results in Impaired Spermatogenesis* *This work was supported by NIH Grants R29-HD-34913 (to W.H.W.), RO1-HD-16842 (to A.J.Z.), and HD-08610. Preliminary results of this study weEndocrinology, 142 2
K. Morita, H. Sasaki, K. Fujimoto, M. Furuse, S. Tsukita (1999)
Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in TestisThe Journal of Cell Biology, 145
H. LaVoie (2003)
The Role of GATA in Mammalian ReproductionExperimental Biology and Medicine, 228
W. Lui, K. Sze, Will Lee (2006)
Nectin‐2 expression in testicular cells is controlled via the functional cooperation between transcription factors of the Sp1, CREB, and AP‐1 familiesJournal of Cellular Physiology, 207
Robert Viger, H. Taniguchi, N. Robert, J. Tremblay (2004)
Role of the GATA family of transcription factors in andrology.Journal of andrology, 25 4
J. Tremblay, Robert Viger (2001)
GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements.Endocrinology, 142 3
Printed in U.S.A. Copyright © 1999 by The Endocrine Society Expression and Regulation of Transcription Factors
B. Strahl, C. Allis (2000)
The language of covalent histone modificationsNature, 403
J. MacLean, M. Wilkinson (2005)
Gene regulation in spermatogenesis.Current topics in developmental biology, 71
D. Rudolph, A. Tafuri, P. Gass, G. Hämmerling, B. Arnold, G. Schütz (1998)
Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein.Proceedings of the National Academy of Sciences of the United States of America, 95 8
I. Ketola, M. Anttonen, T. Vaskivuo, J. Tapanainen, J. Toppari, M. Heikinheimo (2002)
Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis.European journal of endocrinology, 147 3
A. Gow, C. Southwood, Jing Li, M. Pariali, G. Riordan, S. Brodie, J. Danias, J. Bronstein, B. Kachar, R. Lazzarini (1999)
CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp/Claudin-11 Null MiceCell, 99
Susan Hair, David Joseph, Frank French, Marco Conti (1988)
Follicle-stimulating hormone induces transient expression of the protooncogene c-fos in primary Sertoli cell cultures.Molecular endocrinology, 2 1
J. Mankertz, S. Tavalali, H. Schmitz, A. Mankertz, E. Riecken, Michael Fromm, J. Schulzke (2000)
Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma.Journal of cell science, 113 ( Pt 11)
K. Yomogida, Haruo Ohtani, Hideo Harigae, Etsuro Ito, Yoshitake Nishimune, J. Engel, Masayuki Yamamoto (1994)
Developmental stage- and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells.Development, 120 7
E. Hummler, T. Cole, J. Blendy, R. Ganss, Adriano Aguzzii, W. Schmid, F. Beermann, Gonther Schotz (1994)
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.Proceedings of the National Academy of Sciences of the United States of America, 91 12
W. Lui, D. Mruk, Will Lee, C. Cheng (2003)
Sertoli Cell Tight Junction Dynamics: Their Regulation During Spermatogenesis1, 68
C. Cheng, D. Mruk (2002)
Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development.Physiological reviews, 82 4
J. Mankertz, S. Tavalali, H. Schmitz, A. Mankertz, E. Riecken, M. Fromm, J. Schulzke (2000)
Expression from the human occludin promoter is affected by tumor necrosis factor α and interferon γ
Robert Viger, C. Mertineit, J. Trasler, M. Nemer (1998)
Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter.Development, 125 14
The expression of claudin‐11, a key integral tight junction protein, is tightly regulated to ensure that the integrity of the seminiferous epithelium could be maintained during the translocation of spermatocytes at the blood–testis barrier at stages VIII–IX. In this study, we elucidate how the overlapping GATA/NF‐Y motif within the core promoter of claudin‐11 gene is modulated by differential binding of various transcription factors, resulting in dual transcriptional control. Using electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assay, we confirmed that GATA, nuclear factor YA (NF‐YA), and cAMP response element‐binding protein (CREB) form a complex in vivo and bind to the GATA/NF‐Y region to promote claudin‐11 gene transcription. Such gene activations were significantly reduced in the presence of siRNA specific to these transcription factors. GATA and CREB transactivation could be further modulated by the presence of Smad3 and Smad4 proteins. Binding of Smad proteins at the GATA/NF‐Y motif could repress the GATA and CREB transactivation of claudin‐11 gene. Such repression which required the recruitment and physical interactions of histone deacetylase 1 and its co‐repressor, mSin3A with Smad proteins, was abolished by treatment with Trichostatin A, thus suggesting the involvement of histone deacetylation at the site of the promoter region. It is believed that cyclic changes in the ratio of positive regulators (GATA, NF‐Y, and CREB) to negative regulators (Smads) in the seminiferous epithelium during the spermatogenic cycle might provide a precise control in claudin‐11 gene transcription. J. Cell. Physiol. 211: 638–648, 2007. © 2007 Wiley‐Liss, Inc.
Journal of Cellular Physiology – Wiley
Published: Jun 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.