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Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study

Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study Ketoprofen (3‐benzoyl‐α‐methylbenzeneacetic acid) is a widely used nonsteroidal anti‐inflammatory drug (NSAID), always administered in the form of drug–excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients—lactose (LAC) and polyvinylpyrrolidone (PVP)—was evaluated, through vibrational spectroscopy techniques (both Raman and Inelastic Neutron Scattering (INS)). Spectral evidence of drug:excipient close contacts, which were enhanced by aging, was verified for the (1:1) (w:w) (ketoprofen:PVP) and (ketoprofen:LAC) PMs, both by Raman and INS. These interactions were found to involve mainly the central carbonyl and the terminal methyl‐carboxylic moieties of the ketoprofen molecule, this being reflected in particular vibrational modes, such as the methyl torsion, the out‐of‐plane C&bond;OH bending, and the inter‐ring C&dbond;O stretching. © 2006 Wiley Periodicals, Inc. Biopolymers 82: 420–424, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biopolymers Wiley

Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study

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References (16)

Publisher
Wiley
Copyright
Copyright © 2006 Wiley Periodicals, Inc., A Wiley Company
ISSN
0006-3525
eISSN
1097-0282
DOI
10.1002/bip.20517
pmid
16575873
Publisher site
See Article on Publisher Site

Abstract

Ketoprofen (3‐benzoyl‐α‐methylbenzeneacetic acid) is a widely used nonsteroidal anti‐inflammatory drug (NSAID), always administered in the form of drug–excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients—lactose (LAC) and polyvinylpyrrolidone (PVP)—was evaluated, through vibrational spectroscopy techniques (both Raman and Inelastic Neutron Scattering (INS)). Spectral evidence of drug:excipient close contacts, which were enhanced by aging, was verified for the (1:1) (w:w) (ketoprofen:PVP) and (ketoprofen:LAC) PMs, both by Raman and INS. These interactions were found to involve mainly the central carbonyl and the terminal methyl‐carboxylic moieties of the ketoprofen molecule, this being reflected in particular vibrational modes, such as the methyl torsion, the out‐of‐plane C&bond;OH bending, and the inter‐ring C&dbond;O stretching. © 2006 Wiley Periodicals, Inc. Biopolymers 82: 420–424, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com

Journal

Biopolymers – Wiley

Published: Jul 1, 2006

Keywords: ketoprofen; drug–excipient interactions; Raman; inelastic neutron scattering

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