DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore

N. Saha; J. S. H. Tay; G. K. Heng; S. E. Humphries

doi:10.1111/j.1399-0004.1993.tb03861.x

$Saha N, Tay JSH, Heng CK, Humphries SE. DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore. Clin Genet 1993: 44: 113–120. © Munksgaard, 1993 Three DNA polymorphisms (Ins/Del, XbaI and EcoRI) of the apolipoprotein B gene and their influence on body-mass index, serum lipids and apolipoprotein levels were studied in 181 healthy Indians of both sexes (121 males and 60 females), aged between 17 and 71 years. The frequencies of X+ (XbaI) and Del (Ins/Del) of the signal peptide region in Indians were found to be significantly lower (0.17 and 0.11, respectively) compared to the frequencies in Caucasians (0.50 and 0.32, respectively) (P < 0.025). The frequency of E—(EcoRI) was similar to that in Caucasians (0.10 vs 0.15). A highly significant linkage disequilibrium was observed between the XbaI site and Ins/Del polymorphism of the apo B gene in this sample (X2= 31.9, P<0.001). The simultaneous presence of Del and X+ allele was significantly associated with higher body mass index (X2= 11.43, P<0.005), serum total cholesterol (X2= 5.11; P<0.025) and triglyceride (X2= 6.42; P< 0.025) levels. Mean values of adjusted BMI and serum triglyceride levels were found to be 29.0\pm1.92 vs 23.7\pm 0.67 (P<0.025) and 278.0\pm 60.78 vs 140.4\pm 15.43 mg/d1 (P<0.05), respectively, in subjects with Del and X+ compared to others. The multiple regression tests showed that 3.3 and 5.8% of the total variability of BMI is explained by Ins/Del and XbaI polymorphism, respectively, in this sample (P= 0.06 and 0.02), while 3.8% of serum triglyceride levels was explained by Ins/Del polymorphism of the apo B gene (P= 0.04). Further, the serum HDL cholesterol level was significantly associated with XbaI polymorphism, with X+ having significantly lower HDL cholesterol, and it explained about 5% of the total variability (P= 0.02).$

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DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore

Saha, N.; Tay, J. S. H.; Heng, G. K.; Humphries, S. E.

Follow Clinical Genetics , Volume 44 (3) Wiley – Sep 1, 1993

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DNA polymorphisms of the apolipoprotein B gene are associated with obesity and serum lipids in healthy Indians in Singapore

Saha, N.; Tay, J. S. H.; Heng, G. K.; Humphries, S. E.

Follow Clinical Genetics , Volume 44 (3) Wiley – Sep 1, 1993

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