Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Jacobs, A. Skipor, J. Black, R. Urban, J. Galante (1991)
Release and excretion of metal in patients who have a total hip-replacement component made of titanium-base alloy.The Journal of bone and joint surgery. American volume, 73 10
T. Rae (1986)
The biological response to titanium and titanium-aluminium-vanadium alloy particles. I. Tissue culture studies.Biomaterials, 7
J. J. Jacobs, A. K. Skipor, R. M. Urban, J. Black, L. M. Manion, A. Starr (1994)
Systemic distribution of metal degradation products from titanium alloy total hip replacements: An autopsy study, 19
A. Maurer, K. Merritt, S. Brown (1994)
Cellular uptake of titanium and vanadium from addition of salts or fretting corrosion in vitro.Journal of biomedical materials research, 28 2
W. Slavin (1984)
Graphite Furnace AAS, a Source Book
H. Agins, N Alcock, M. Bansal, E. Salvati, P Wilson, P. Pellicci, P Bullough (1988)
Metallic wear in failed titanium-alloy total hip replacements. A histological and quantitative analysis.The Journal of bone and joint surgery. American volume, 70 3
M. A. Panigutti, K. Merritt, R. J. Bruner, M. J. Kraay, S. A. Brown (1992)
Correlation of allergy, metal levels, implant alloy, and implant damage in patients undergoing revision joint arthroplasties, 15
J. T. Wang, A. Willis, B. Jiranek, K. Merritt, S. A. Brown, S. R. Goldring (1993)
Metal particles of orthopaedic implant materials and their corrosion products stimulate release of PGE2 and Interleukin‐6, products implicated in pathological bone resorption, 18
A. S. Shanbhag, J. Black, J. J. Jacobs, J. O. Galante, T. T. Glant (1994)
Human monocyte response to submicron fabricated and retrieved polyethylene, Ti‐6Al‐4V and Ti particles, 19
J. L. Woodman, J. J. Jacobs, J. O. Galante, R. M. Urban (1984)
Titanium, aluminum, vanadium release from titanium based prosthetic segmental replacement of long bones in baboons. A long term study, 1
J. Woodman, J. Jacobs, J. Galante, R. Urban (1984)
Metal ion release from titanium‐based prosthetic segmental replacements of long bones in baboons: A long‐term studyJournal of Orthopaedic Research, 1
H. J. Agins, N. W. Alcock, M. Bansal, E. A. Salvati, P. D. Wilson, P. M. Pellicci, P. G. Bullough (1988)
Metallic wear in failed titanium alloy total hip replacement, 70A
K. Merritt, R. Margevicius, S. Brown (1992)
Storage and elimination of titanium, aluminum, and vanadium salts, in vivo.Journal of biomedical materials research, 26 11
B. Stulberg, K. Merritt, T. Bauer (1994)
Metallic wear debris in metal‐backed patellar failureJournal of Applied Biomaterials, 5
R. Thomas, R. Archuleta (1980)
Titanium retention in mice.Toxicology letters, 6 2
T. Rae (1986)
The biological response to titanium and titanium‐aluminum‐vanadium alloy particles, 7
Titanium and its alloy of 6% aluminum and 4% vanadium are used extensively in orthopedic and dental surgery. However, in conditions of motion leading to wear, there is significant generation of wear products with deposition of black debris in the tissue. The questions remain as to how much of this debris is generated and to where it is transported. Previous studies have been hampered by low levels of detected elements giving values just above the background levels found in normal tissue and body fluids. The purpose of these experiments was to increase the body burden of titanium and vanadium by injecting larger doses of titanium and vanadium salts over an extended period of time. Each animal (Syrian hamster) received 100 μg of each element once a week for six weeks. The hamster was sacrificed on the seventh week and body fluids and tissue harvested. The results indicate that in the experimental animals there was transport of vanadium with levels above control in urine, plasma, liver, spleen, and the mineralized portion and organic portion of bone. Titanium had less transport but still showed levels in the experimental animals in plasma, kidney, liver, spleen, and both phases of bone above those in the control animals. Neither element was found above control levels in lung or red blood cells. The levels of titanium and vanadium in control bone were high, possibly indicating bone as a site for storage and accumulation of these elements when encountered in the activities of daily living. © 1995 John Wiley & Sons, Inc.
Journal of Biomedical Materials Research Part A – Wiley
Published: Oct 1, 1995
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.