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S. Hodge, V. Vieland, D. Greenberg (2002)
HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity.American journal of human genetics, 70 2
C. Smith (1963)
Testing for heterogeneity of recombination fraction values in Human GeneticsAnnals of Human Genetics, 27
R. Davies (1977)
Hypothesis testing when a nuisance parameter is present only under the alternativeBiometrika, 74
S. Self, K. Liang (1987)
Asymptotic Properties of Maximum Likelihood Estimators and Likelihood Ratio Tests under Nonstandard ConditionsJournal of the American Statistical Association, 82
G. Abecasis, S. Cherny, W. Cookson, L. Cardon (2002)
Merlin—rapid analysis of dense genetic maps using sparse gene flow treesNature Genetics, 30
K. Liang, P. Rathouz (1999)
Hypothesis Testing Under Mixture Models: Application to Genetic Linkage AnalysisBiometrics, 55
L. Kruglyak, M. Daly, Mary Reeve-Daly, E. Lander (1996)
Parametric and nonparametric linkage analysis: a unified multipoint approach.American journal of human genetics, 58 6
C. Xing, R. Elston (2006)
Distribution and magnitude of type I error of model‐based multipoint lod scores: implications for multipoint mod scoresGenetic Epidemiology, 30
H. Chernoff, E. Lander (1995)
Asymptotic distribution of the likelihood ratio test that a mixture of two binomials is a single binomialJournal of Statistical Planning and Inference, 43
J. Faraway (1993)
Distribution of the admixture test for the detection of linkage under heterogeneityGenetic Epidemiology, 10
J. Ott (1985)
Analysis of Human Genetic Linkage
P. Abreu, S. Hodge, D. Greenberg (2002)
Quantification of type I error probabilities for heterogeneity LOD scoresGenetic Epidemiology, 22
R. Brent (1974)
Algorithms for minimization without derivativesIEEE Transactions on Automatic Control, 19
(1995)
Testing for Latent Structure
M. Chiano, J. Yates (1995)
Linkage detection under heterogeneity and the mixture problemAnnals of Human Genetics, 59
Jian Huang, V. Vieland (2001)
The Null Distribution of the Heterogeneity Lod Score Does Depend on the Assumed Genetic Model for the TraitHuman Heredity, 52
G. Zheng, Zehua Chen (2005)
Comparison of Maximum Statistics for Hypothesis Testing When a Nuisance Parameter Is Present only under the AlternativeBiometrics, 61
Danyu Lin, F. Zou (2004)
Assessing genomewide statistical significance in linkage studiesGenetic Epidemiology, 27
J. Ott (1983)
Linkage analysis and family classification under heterogeneityAnnals of Human Genetics, 47
S. Hodge, L. Rodríguez-Murillo, L. Strug, D. Greenberg (2008)
Multipoint lods provide reliable linkage evidence despite unknown limiting distribution: type I error probabilities decrease with sample size for multipoint lods and modsGenetic Epidemiology, 32
D. Greenberg, P. Abreu (2001)
Determining trait locus position from multipoint analysis: Accuracy and power of three different statisticsGenetic Epidemiology, 21
S. Hodge, C. Anderson, K. Neiswanger, R. Sparkes, D. Rimoin (1983)
The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity.American journal of human genetics, 35 6
M. Lemdani, O. Pons (1995)
Tests for genetic linkage and homogeneity.Biometrics, 51 3
The distribution of two‐point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two‐point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution , which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. Genet. Epidemiol. 34: 912‐916, 2010.© 2010 Wiley‐Liss, Inc.
Genetic Epidemiology – Wiley
Published: Dec 1, 2010
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