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Distribution of model‐based multipoint heterogeneity lod scores

Distribution of model‐based multipoint heterogeneity lod scores The distribution of two‐point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two‐point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution , which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. Genet. Epidemiol. 34: 912‐916, 2010.© 2010 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genetic Epidemiology Wiley

Distribution of model‐based multipoint heterogeneity lod scores

Genetic Epidemiology , Volume 34 (8) – Dec 1, 2010

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References (23)

Publisher
Wiley
Copyright
© 2010 Wiley‐Liss, Inc.
ISSN
0741-0395
eISSN
1098-2272
DOI
10.1002/gepi.20535
pmid
21104892
Publisher site
See Article on Publisher Site

Abstract

The distribution of two‐point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two‐point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution , which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. Genet. Epidemiol. 34: 912‐916, 2010.© 2010 Wiley‐Liss, Inc.

Journal

Genetic EpidemiologyWiley

Published: Dec 1, 2010

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