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E. Kathmann, J. Lipsky (1997)
Cloning of a cDNA encoding a constitutively expressed rat liver cytosolic aldehyde dehydrogenase.Biochemical and biophysical research communications, 236 2
M. Wagner, B. Han, T. Jessell (1992)
Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay.Development, 116 1
Jiangming Luo, H. Sucov, J. Bader, R. Evans, V. Giguère (1996)
Compound mutants for retinoic acid receptor (RAR)β and RARα1 reveal developmental functions for multiple RARβ isoformsMechanisms of Development, 55
J. Rossant, R. Zirngibl, D. Cado, M. Shago, V. Giguère (1991)
Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.Genes & development, 5 8
S. Shimeld (1996)
Retinoic acid, HOX genes and the anterior‐posterior axis in chordatesBioEssays, 18
S. Pemrick, D. Lucas, J. Grippo (1994)
The retinoid receptors.Leukemia, 8 Suppl 3
Wang (1996)
10.1074/jbc.271.27.16288J Biol Chem, 271
J. Napoli (1996)
Retinoic acid biosynthesis and metabolismThe FASEB Journal, 10
DJ Mangelsdorf, K Umesono, RM Evans (1994)
The retinoids: biology, chemistry, and medicine
L. Hsu, W. Chang, I. Hoffmann, G. Duester (1999)
Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid.The Biochemical journal, 339 ( Pt 2)
P. McCaffery, U. Dräger (1994)
Hot spots of retinoic acid synthesis in the developing spinal cord.Proceedings of the National Academy of Sciences of the United States of America, 91 15
M. Kaufman (1992)
The Atlas of Mouse Development
H. Ang, L. Deltour, T. Hayamizu, M. Žgombic-Knight, G. Duester (1996)
Retinoic Acid Synthesis in Mouse Embryos during Gastrulation and Craniofacial Development Linked to Class IV Alcohol Dehydrogenase Gene Expression (*)The Journal of Biological Chemistry, 271
R. Haselbeck, G. Duester (1998)
ADH1 and ADH4 alcohol/retinol dehydrogenases in the developing adrenal blastema provide evidence for embryonic retinoid endocrine functionDevelopmental Dynamics, 213
P. Plack, S. Kon (1961)
A comparative survey of the distribution of vitamin A aldehyde in eggs.The Biochemical journal, 81
Mendelsohn (1994)
10.1242/dev.120.10.2749Development, 120
A Domingo, AJ Sarria, RM Evans, MW Klymkowsky (1992)
The cytoskeleton: a practical approach
Robert Haselbeck, H. Ang, Louise Deltour, G. Duester (1997)
Retinoic acid and alcohol/retinol dehydrogenase in the mouse adrenal gland: a potential endocrine source of retinoic acid during development.Endocrinology, 138 7
C. Mendelsohn, D. Lohnes, D. Décimo, T. Lufkin, M. Lemeur, P. Chambon, M. Mark (1994)
Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.Development, 120 10
M. Maden, R. Blomhoff (1994)
Role of retinoids in embryonic development.
M. Lee, C. Manthey, N. Sládek (1991)
Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid.Biochemical pharmacology, 42 6
U. Rout, R. Holmes (1985)
Isoelectric focusing studies of aldehyde dehydrogenases from mouse tissues: variant phenotypes of liver, stomach and testis isozymes.Comparative biochemistry and physiology. B, Comparative biochemistry, 81 3
L. Solomin, C. Johansson, R. Zetterström, R. Bissonnette, R. Heyman, L. Olson, U. Lendahl, J. Frisén, T. Perlmann (1998)
Retinoid-X receptor signalling in the developing spinal cordNature, 395
Lohnes (1994)
10.1242/dev.120.10.2723Development, 120
McCaffery (1992)
10.1242/dev.115.2.371Development, 115
D. Corey, X. Breakefield (1994)
Transcription factors in inner ear development.Proceedings of the National Academy of Sciences of the United States of America, 91
B Hogan, R Beddington, F Costantini, E Lacy (1994)
Manipulating the mouse embryo
R. Haselbeck, G. Duester (1998)
ADH4-lacZ transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crest.Alcoholism, clinical and experimental research, 22 7
J. Gurdon (1995)
Normal table of Xenopus laevis (Daudin)Trends in Genetics, 11
L. Hsu, Wen-Chung Chang, Akitaka ShibuyaS, Akira Yoshida (1992)
Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli.The Journal of biological chemistry, 267 5
Wojciech El, N. Ghyselinck, T. Samad, V. Dupé, P. Kastner, E. Borrelli, P. Chambon (1998)
Impaired locomotion and dopamine signaling in retinoid receptor mutant mice.Science, 279 5352
P. McCaffery, Mi-Ock Lee, Michael Wagner, N. Sládek, U. Drager (1992)
Asymmetrical retinoic acid synthesis in the dorsoventral axis of the retina.Development, 115 2
FM Ausubel, R Brent, RE Kingston, DD Moore, JG Seidman, JA Smith, K Struhl (1989)
Current protocols in molecular biology, 2
K. Niederreither, V. Subbarayan, P. Dollé, P. Chambon (1999)
Embryonic retinoic acid synthesis is essential for early mouse post-implantation developmentNature Genetics, 21
L. Deltour, M. Foglio, G. Duester (1999)
Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice.Developmental genetics, 25 1
Robert Haselbeck, G. Duester (1997)
Regional restriction of alcohol/retinol dehydrogenases along the mouse gastrointestinal epithelium.Alcoholism, clinical and experimental research, 21 8
B. Mascrez, Manuel Mark, A. Dierich, N. Ghyselinck, Philippe Kastner, Pierre Chambon (1998)
The RXRalpha ligand-dependent activation function 2 (AF-2) is important for mouse development.Development, 125 23
Dickman (1997)
10.1242/dev.124.16.3111Development, 124
(1996)
Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate
G. Duester (1996)
Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis.Biochemistry, 35 38
P. Dockham, Mi-Ock Lee, N. Sládek (1992)
Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde.Biochemical pharmacology, 43 11
PD Vize, DA Melton, A Hemmati‐Brivanlou, RM Harland (1991)
Methods in cell biology, 36
L. Gudas, M. Sporn, A. Roberts (1984)
Cellular biology and biochem-istry of the retinoids
(1992)
Studying intermediate filaments
P. Penzes, X. Wang, J. Napoli (1997)
Enzymatic characteristics of retinal dehydrogenase type I expressed in Escherichia coli.Biochimica et biophysica acta, 1342 2
J. Sambrook, E. Fritsch, T. Maniatis (2001)
Molecular Cloning: A Laboratory Manual
H. Ang, G. Duester (1997)
Initiation of retinoid signaling in primitive streak mouse embryos: Spatiotemporal expression patterns of receptors and metabolic enzymes for ligand synthesisDevelopmental Dynamics, 208
James Wilson, C. Roth, J. Warkany (1953)
An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation.The American journal of anatomy, 92 2
(1991)
Injection of oocytes and embryos
A. Paparo (1985)
The role of the cerebral and visceral ganglia in ciliary activityComparative Biochemistry and Physiology Part A: Physiology, 81
H. Ang, L. Deltour, M. Žgombic-Knight, Michael Wagner, G. Duester (1996)
Expression patterns of class I and class IV alcohol dehydrogenase genes in developing epithelia suggest a role for alcohol dehydrogenase in local retinoic acid synthesis.Alcoholism, clinical and experimental research, 20 6
P. McCaffery, U. Dräger (1994)
High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system.Proceedings of the National Academy of Sciences of the United States of America, 91 16
Mascrez (1998)
10.1242/dev.125.23.4691Development, 125
L Deltour, MH Foglio, G Duester (1999a)
Metabolic deficiencies in alcohol dehydrogenase Adh1, Adh3, and Adh4 null mutant mice: overlapping roles of Adh1 and Adh4 in ethanol clearance and metabolism of retinol to retinoic acid
E Harlow, D Lane (1988)
Antibodies: a laboratory manual
P. Chomczyński, N. Sacchi (1987)
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.Analytical biochemistry, 162 1
Christianna Smith (1965)
STUDIES ON THE THYMUS OF THE MAMMAL. XIV. HISTOLOGY AND HISTOCHEMISTRY OF EMBRYONIC AND EARLY POSTNATAL THYMUSES OF C57BL-6 AND AKR STRAIN MICE.The American journal of anatomy, 116
L. Deltour, M. Foglio, G. Duester (1999)
Metabolic Deficiencies in Alcohol Dehydrogenase Adh1,Adh3, and Adh4 Null Mutant MiceThe Journal of Biological Chemistry, 274
P. Kastner, P. Chambon, M. Leid, R. Blomhoff (1994)
Role of nuclear retinoic acid receptors in the regulation of gene expression.
M Maden (1994)
Vitamin A in health and disease
Duester (1996)
10.1021/bi961176+Biochemistry, 35
E. Dickman, Christina Thaller, Susan Smith (1997)
Temporally-regulated retinoic acid depletion produces specific neural crest, ocular and nervous system defects.Development, 124 16
L. López-Fernández, J. Mazo (1997)
The cytosolic aldehyde dehydrogenase gene (Aldh1) is developmentally expressed in Leydig cellsFEBS Letters, 407
K. Niederreither, P. McCaffery, U. Dräger, P. Chambon, P. Dollé (1997)
Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse developmentMechanisms of Development, 62
P. McCaffery, P. Tempst, G. Lara, U. Dräger (1991)
Aldehyde dehydrogenase is a positional marker in the retina.Development, 112 3
M. Maden, E. Gale, I. Kostetskii, M. Zile (1996)
Vitamin A-deficient quail embryos have half a hindbrain and other neural defectsCurrent Biology, 6
S. Futterman (1962)
Enzymatic oxidation of vitamin A aldehyde to vitamin A acid.The Journal of biological chemistry, 237
P. Vize, D. Melton, A. Hemmati‐Brivanlou, R. Harland (1991)
Assays for gene function in developing Xenopus embryos.Methods in cell biology, 36
Wagner (1992)
10.1242/dev.116.1.55Development, 116
Wayne Balkan, Melissa Colbert, Cheryl Bock, E. Linney (1992)
Transgenic indicator mice for studying activated retinoic acid receptors during development.Proceedings of the National Academy of Sciences of the United States of America, 89
O. Valdenaire, Marion Maus‐Moatti, J. Vincent, Jacques Mallet, P. Vernier (1998)
Retinoic Acid Regulates the Developmental Expression of Dopamine D2 Receptor in Rat Striatal Primary CulturesJournal of Neurochemistry, 71
S. Sockanathan, T. Jessell (1998)
Motor Neuron–Derived Retinoid Signaling Specifies the Subtype Identity of Spinal Motor NeuronsCell, 94
J. Moss, J. Xavier-Neto, J. Xavier-Neto, M. Shapiro, Sara Nayeem, P. McCaffery, U. Dräger, N. Rosenthal (1998)
Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart.Developmental biology, 199 1
McCaffery (1991)
10.1242/dev.112.3.693Development, 112
A. Yoshida, L. Hsu, V. Davé (1992)
Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase.Enzyme, 46 4-5
P. McCaffery, E. Wagner, J. O'neil, M. Petkovich, U. Dräger (1999)
Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expressionMechanisms of Development, 82
Thomas Lufkin (1996)
Transcriptional control of Hox genes in the vertebrate nervous system.Current opinion in genetics & development, 6 5
P. McCaffrery, K. Posch, J. Napoli, L. Gudas, U. Dräger (1993)
Changing patterns of the retinoic acid system in the developing retina.Developmental biology, 158 2
A. Cordier, S. Haumont (1980)
Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice.The American journal of anatomy, 157 3
Lindahl (1984)
10.1016/S0021-9258(20)71308-6J Biol Chem, 259
B. Blumberg, J. Bolado, F. Derguini, A. Craig, T. Moreno, D. Chakravarti, R. Heyman, J. Buck, R. Evans (1996)
Novel retinoic acid receptor ligands in Xenopus embryos.Proceedings of the National Academy of Sciences of the United States of America, 93 10
B. Hogan, C. Thaller, G. Eichele (1992)
Evidence that Hensen's node is a site of retinoic acid synthesisNature, 359
J. Kraft, T. Schuh, M. Juchau, D. Kimelman (1994)
Temporal distribution, localization and metabolism of all-trans-retinol, didehydroretinol and all-trans-retinal during Xenopus development.The Biochemical journal, 301 ( Pt 1)
R. Lindahl, S. Evces (1984)
Rat liver aldehyde dehydrogenase. II. Isolation and characterization of four inducible isozymes.The Journal of biological chemistry, 259 19
D. Lohnes, M. Mark, C. Mendelsohn, P. Dollé, A. Dierich, P. Gorry, A. Gansmuller, P. Chambon (1994)
Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.Development, 120 10
C. Perrone-Capano, U. Porzio (1996)
Epigenetic factors and midbrain dopaminergic neurone developmentBioEssays, 18
J. Labrecque, F. Dumas, A. Lacroix, P. Bhat (1995)
A novel isoenzyme of aldehyde dehydrogenase specifically involved in the biosynthesis of 9-cis and all-trans retinoic acid.The Biochemical journal, 305 ( Pt 2)
B. Mascrez, M. Mark, A. Dierich, N. Ghyselinck, P. Kastner, P. Chambon (1998)
The RXR α ligand-dependent activation function 2 ( AF2 ) is important for mouse development
Yuichi Ono, N. Fukuhara, O. Yoshie (1998)
TAL1 and LIM-Only Proteins Synergistically Induce Retinaldehyde Dehydrogenase 2 Expression in T-Cell Acute Lymphoblastic Leukemia by Acting as Cofactors for GATA3Molecular and Cellular Biology, 18
Dayao Zhao, Dayao Zhao, Peter McCaffery, Kathryn Ivins, Kathryn Ivins, Rachael Neve, Patrick Hogan, William Chin, U. Dräger (1996)
Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase.European journal of biochemistry, 240 1
W. Colledge (1995)
Manipulating the mouse embryo (2nd edn)Trends in Genetics, 11
During vertebrate embryogenesis retinoic acid (RA) synthesis must be spatiotemporally regulated in order to appropriately stimulate various retinoid signaling pathways. Various forms of mammalian aldehyde dehydrogenase (ALDH) have been shown to oxidize the vitamin A precursor retinal to RA in vitro. Here we show that injection of Xenopus embryos with mRNAs for either mouse Aldh1 or mouse Raldh2 stimulates RA synthesis at low and high levels, respectively, while injection of human ALDH3 mRNA is unable to stimulate any detectable level of RA synthesis. This provides evidence that some members of the ALDH gene family can indeed perform RA synthesis in vivo. Whole‐mount immunohistochemical analyses of mouse embryos indicate that ALDH1 and RALDH2 proteins are localized in distinct tissues. RALDH2 is detected at E7.5–E10.5 primarily in trunk tissue (paraxial mesoderm, somites, pericardium, midgut, mesonephros) plus transiently from E8.5–E9.5 in the ventral optic vesicle and surrounding frontonasal region. ALDH1 is first detected at E9.0–E10.5 primarily in cranial tissues (ventral mesencephalon, dorsal retina, thymic primordia, otic vesicles) and in the mesonephros. As previous findings indicate that embryonic RA is more abundant in trunk rather than cranial tissues, our findings suggest that Raldh2 and Aldh1 control distinct retinoid signaling pathways by stimulating high and low RA biosynthetic activities, respectively, in various trunk and cranial tissues. Dev. Genet. 25:353–364, 1999. © 1999 Wiley‐Liss, Inc.
Genesis: the Journal of Genetics and Development – Wiley
Published: Jan 1, 1999
Keywords: ; ; ; ;
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