Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Differential effects of anesthetic agents on regional blood flow and central hemodynamic parameters in rats

Differential effects of anesthetic agents on regional blood flow and central hemodynamic... Three commonly used anesthetic agents (pentobarbital, chloralose‐urethane, and inactin) were studied in a rat model. The radiolabeled microsphere technique was used to evaluate rats anesthetized (no reaction to pain stimulus) with the three drugs as compared to awake unanesthetized animals. Of the three anesthetic agents studied, pentobarbital caused the smallest alteration in central hemodynamic parameters. Chloralose‐urethane significantly lowered cardiac output (56%), stroke volume (35%), and minute work (51%). Chloralose‐urethane also significantly increased total peripheral resistance (59%). Inactin at the concentration used in the present study had very little effect on cardiac index, heart rate, stroke volume, and minute work but significantly increased total peripheral resistance and mean arterial pressure. All three anesthetic agents reduced cerebral and skeletal muscle blood flows equally. While pentobarbital and chloralose‐urethane significantly decreased renal blood flow (33%), inactin did not change flow to the kidney. It is concluded that anesthetic agents used in small animal experiments should be chosen carefully so that they do not influence blood flow to the organ being studied. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug Development Research Wiley

Differential effects of anesthetic agents on regional blood flow and central hemodynamic parameters in rats

Loading next page...
 
/lp/wiley/differential-effects-of-anesthetic-agents-on-regional-blood-flow-and-qvzOaBdI75

References (26)

Publisher
Wiley
Copyright
Copyright © 1988 Wiley‐Liss, Inc., A Wiley Company
ISSN
0272-4391
eISSN
1098-2299
DOI
10.1002/ddr.430140105
Publisher site
See Article on Publisher Site

Abstract

Three commonly used anesthetic agents (pentobarbital, chloralose‐urethane, and inactin) were studied in a rat model. The radiolabeled microsphere technique was used to evaluate rats anesthetized (no reaction to pain stimulus) with the three drugs as compared to awake unanesthetized animals. Of the three anesthetic agents studied, pentobarbital caused the smallest alteration in central hemodynamic parameters. Chloralose‐urethane significantly lowered cardiac output (56%), stroke volume (35%), and minute work (51%). Chloralose‐urethane also significantly increased total peripheral resistance (59%). Inactin at the concentration used in the present study had very little effect on cardiac index, heart rate, stroke volume, and minute work but significantly increased total peripheral resistance and mean arterial pressure. All three anesthetic agents reduced cerebral and skeletal muscle blood flows equally. While pentobarbital and chloralose‐urethane significantly decreased renal blood flow (33%), inactin did not change flow to the kidney. It is concluded that anesthetic agents used in small animal experiments should be chosen carefully so that they do not influence blood flow to the organ being studied.

Journal

Drug Development ResearchWiley

Published: Jan 1, 1988

Keywords: pentobarbital; chloralose‐urethane; inactin; central hemodynamics; kidney flow; brain flow

There are no references for this article.