Access the full text.
Sign up today, get DeepDyve free for 14 days.
B. Frost, E. Forestier, G. Gustafsson, P. Nygren, M. Hellebostad, G. Jónmundsson, J. Kanerva, K. Schmiegelow, R. Larsson, G. Lönnerholm (2005)
Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemiaLeukemia, 19
J. Nourse, J. Mellentin, N. Galili, J. Wilkinson, E. Stanbridge, Stephen Smith, M. Cleary (1990)
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factorCell, 60
C. Mullighan, S. Goorha, I. Radtke, C. Miller, E. Coustan-Smith, J. Dalton, Kevin Girtman, S. Mathew, Jing Ma, S. Pounds, X. Su, C. Pui, M. Relling, W. Evans, S. Shurtleff, J. Downing (2007)
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemiaNature, 446
J. Chessells, G. Swansbury, B. Reeves, C. Bailey, S. Richards (1997)
Cytogenetics and prognosis in childhood lymphoblastic leukaemia: results of MRC UKALL XBritish Journal of Haematology, 99
Andrew Carroll, W. Crist, R. Parmley, M. Roper, Cooper, WH Finley (1984)
Pre-B cell leukemia associated with chromosome translocation 1;19.Blood, 63 3
Guibin Chen, W. Zeng, A. Miyazato, E. Billings, J. Maciejewski, S. Kajigaya, E. Sloand, N. Young (2005)
Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia.Blood, 105 2
C. Schwaenen, M. Nessling, S. Wessendorf, Tatjana Salvi, G. Wrobel, B. Radlwimmer, H. Kestler, C. Haslinger, S. Stilgenbauer, H. Döhner, M. Bentz, P. Lichter (2004)
Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations.Proceedings of the National Academy of Sciences of the United States of America, 101 4
B. Zielinski, S. Gratias, G. Toedt, F. Mendrzyk, D. Stange, B. Radlwimmer, D. Lohmann, P. Lichter (2005)
Detection of chromosomal imbalances in retinoblastoma by matrix‐based comparative genomic hybridizationGenes, 43
D. Lee, Y. Lee, Y. Yun, Young‐Ree Kim, Seokhun Jeong, Young Lee, C. She, S. Yoon, H. Shin, Yongsoo Kim, H. Cho (2003)
A study on the incidence of ABL gene deletion on derivative chromosome 9 in chronic myelogenous leukemia by interphase fluorescence in situ hybridization and its association with disease progressionGenes, 37
S. Kreil, M. Pfirrmann, C. Haferlach, K. Waghorn, A. Chase, R. Hehlmann, A. Reiter, A. Hochhaus, N. Cross (2007)
Heterogeneous prognostic impact of derivative chromosome 9 deletions in chronic myelogenous leukemia.Blood, 110 4
(2007)
Chronic Myelogenous Leukemia (CML) Study Group
G. Lenz, I. Nagel, R. Siebert, A. Roschke, W. Sanger, G. Wright, Sandeep Dave, Bruce Tan, Hong Zhao, A. Rosenwald, H. Muller-Hermelink, R. Gascoyne, E. Campo, Elaine Jaffe, E. Smeland, Richard Fisher, W. Kuehl, Wing Chan, L. Staudt (2007)
Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell–like diffuse large B cell lymphomaThe Journal of Experimental Medicine, 204
F. Staal, G. Cario, G. Cazzaniga, T. Haferlach, M. Heuser, W. Hofmann, K. Mills, M. Schrappe, M. Stanulla, L. Wingen, J. Dongen, B. Schlegelberger (2006)
Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networksLeukemia, 20
L. Zutven, E. Drunen, J. Bont, M. Wattel, M. Boer, R. Pieters, A. Hagemeijer, R. Slater, H. Beverloo (2005)
CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemiaLeukemia, 19
H. Willenbrock, Jane Fridlyand (2005)
A comparison study: applying segmentation to array CGH data for downstream analysesBioinformatics, 21 22
F. Uckun, M. Sensel, H. Sather, P. Gaynon, D. Arthur, B. Lange, P. Steinherz, P. Kraft, R. Hutchinson, J. Nachman, G. Reaman, N. Heerema (1998)
Clinical significance of translocation t(1;19) in childhood acute lymphoblastic leukemia in the context of contemporary therapies: a report from the Children's Cancer Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 16 2
S. Hunger, N. Galili, A. Carroll, W. Crist, M. Link, Michael Cleary (1991)
The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias.Blood, 77 4
J. Strefford, H. Worley, K. Barber, S. Wright, A. Stewart, H. Robinson, G. Bettney, F. Delft, M. Atherton, Teresa Davies, M. Griffiths, S. Hing, F. Ross, P. Talley, V. Saha, A. Moorman, C. Harrison (2007)
Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridizationOncogene, 26
T. Flohr, A. Schrauder, G. Cazzaniga, R. Panzer-Grümayer, V. Velden, S. Fischer, M. Stanulla, G. Basso, F. Niggli, B. Schäfer, R. Sutton, R. Koehler, M. Zimmermann, M. Valsecchi, H. Gadner, G. Masera, M. Schrappe, J. Dongen, A. Biondi, C. Bartram (2008)
Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemiaLeukemia, 22
E. Kuchinskaya, A. Nordgren, M. Heyman, J. Schoumans, M. Corcoran, J. Staaf, Å. Borg, S. Söderhäll, D. Grandér, M. Nordenskjöld, E. Blennow (2007)
Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles?Leukemia, 21
A. Moorman, S. Richards, H. Robinson, J. Strefford, B. Gibson, S. Kinsey, T. Eden, A. Vora, C. Mitchell, C. Harrison (2007)
Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21).Blood, 109 6
D. Steinemann, B. Skawran, T. Becker, Marcel Tauscher, A. Weigmann, L. Wingen, Sarah Tauscher, Tanja Hinrichsen, S. Hertz, P. Flemming, Jacobus Flik, B. Wiese, H. Kreipe, P. Lichter, B. Schlegelberger, L. Wilkens (2006)
Assessment of differentiation and progression of hepatic tumors using array-based comparative genomic hybridization.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 4 10
J. Curry, Mathew Glaser, Martyn Smith (2001)
Real‐time reverse transcription polymerase chain reaction detection and quantification of t(1;19) (E2A–PBX1) fusion genes associated with leukaemiaBritish Journal of Haematology, 115
E. Tsellou, C. Troungos, M. Moschovi, F. Athanasiadou‐Piperopoulou, S. Polychronopoulou, H. Kosmidis, M. Kalmanti, A. Hatzakis, N. Dessypris, A. Kalofoutis, E. Petridou (2005)
Hypermethylation of CpG islands in the promoter region of the p15INK4B gene in childhood acute leukaemia.European journal of cancer, 41 4
U. Nygaard, J. Larsen, Tim Kristensen, F. Wesenberg, Ó. Jónsson, N. Carlsen, E. Forestier, M. Kirchhoff, J. Larsen, K. Schmiegelow, I. Christensen (2006)
Flow Cytometric DNA index, G-band Karyotyping, and Comparative Genomic Hybridization in Detection of High Hyperdiploidy in Childhood Acute Lymphoblastic LeukemiaJournal of Pediatric Hematology/Oncology, 28
R. Kuiper, E. Schoenmakers, S. Reijmersdal, J. Hehir-Kwa, A. Kessel, F. Leeuwen, P. Hoogerbrugge (2007)
High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progressionLeukemia, 21
H. Tagawa, S. Karnan, R. Suzuki, K. Matsuo, Xiaohua Zhang, Akinobu Ota, Y. Morishima, S. Nakamura, M. Seto (2005)
Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIMOncogene, 24
J. Strefford, F. Delft, H. Robinson, H. Worley, O. Yiannikouris, R. Selzer, T. Richmond, I. Hann, T. Bellotti, M. Raghavan, B. Young, V. Saha, C. Harrison (2006)
Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21.Proceedings of the National Academy of Sciences of the United States of America, 103 21
I. Hann, A. Vora, G. Harrison, C. Harrison, O. Eden, F. Hill, B. Gibson, S. Richards (2001)
Determinants of outcome after intensified therapy of childhood lymphoblastic leukaemia: results from Medical Research Council United Kingdom acute lymphoblastic leukaemia XI protocolBritish Journal of Haematology, 113
E. Forestier, B. Johansson, G. Gustafsson, G. Borgström, G. Kerndrup, J. Jóhannsson, S. Heim (2000)
Prognostic impact of karyotypic findings in childhood acute lymphoblastic leukaemia: a Nordic series comparing two treatment periodsBritish Journal of Haematology, 110
Jacques Dongen, T. Seriu, E. Panzer-Grümayer, Andrea Biondi, M. Pongers-Willemse, Lilly Corral, Frank Stolz, M. Schrappe, Giuseppe Masera, W. Kamps, H. Gadner, E. Wering, Wolf-Dieter Ludwig, Giuseppe Basso, Marianne Bruijn, G. Cazzaniga, K. Hettinger, A. Berg, W. Hop, H. Riehm, C. Bartram (1998)
Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhoodThe Lancet, 352
R. Nowak, U. Oelschlägel, Torsten Heider, R. Naumann, G. Ehninger (2000)
Some limitations in the detection of residual aneuploid cells with dna quantification on immunophenotyped cells by flow cytometryBritish Journal of Haematology, 110
M. Stanulla, E. Schaeffeler, T. Flohr, G. Cario, A. Schrauder, M. Zimmermann, K. Welte, W. Ludwig, C. Bartram, U. Zanger, M. Eichelbaum, M. Schrappe, M. Schwab (2005)
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.JAMA, 293 12
M. Béné, G. Castoldi, W. Knapp, W. Ludwig, E. Matutes, A. Órfão, M. Veer (1995)
Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL).Leukemia, 9 10
L. Kager, T. Lion, A. Attarbaschi, M. Koenig, S. Strehl, O. Haas, M. Dworzak, M. Schrappe, H. Gadner, G. Mann (2007)
Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian childrenHaematologica, 92
N. Kawamata, S. Ogawa, M. Zimmermann, Motohiro Kato, M. Sanada, K. Hemminki, Go Yamatomo, Y. Nannya, R. Koehler, T. Flohr, C. Miller, J. Harbott, W. Ludwig, M. Stanulla, M. Schrappe, C. Bartram, H. Koeffler (2007)
Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray.Blood, 111 2
K. Paulsson, M. Heidenblad, H. Mörse, Å. Borg, T. Fioretos, B. Johansson (2006)
Identification of cryptic aberrations and characterization of translocation breakpoints using array CGH in high hyperdiploid childhood acute lymphoblastic leukemiaLeukemia, 20
H. Einsiedel, T. Taube, R. Hartmann, S. Wellmann, G. Seifert, G. Henze, K. Seeger (2002)
Deletion analysis of p16(INKa) and p15(INKb) in relapsed childhood acute lymphoblastic leukemia.Blood, 99 12
D. Mirebeau, C. Acquaviva, S. Suciu, Raphaëlle Bertin, N. Dastugue, A. Robert, P. Boutard, F. Mechinaud, E. Plouvier, J. Otten, E. Vilmer, H. Cavé (2006)
The prognostic significance of CDKN2A, CDKN2B and MTAP inactivation in B-lineage acute lymphoblastic leukemia of childhood. Results of the EORTC studies 58881 and 58951.Haematologica, 91 7
B. Schlegelberger, S. Metzke, S. Harder, R. Zühlke‐Jenisch, Yanming Zhang, R. Siebert (1999)
Classical and Molecular Cytogenetics of Tumor Cells
S. Breit, M. Stanulla, T. Flohr, M. Schrappe, W. Ludwig, Gabriele Tolle, M. Happich, M. Muckenthaler, A. Kulozik (2006)
Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia.Blood, 108 4
T. Moreno, G. Gustafsson, S. Garwicz, D. Grandér, G. Jónmundsson, B. Frost, A. Mäkipernaa, O. Rasool, E. Savolainen, K. Schmiegelow, S. Söderhäll, K. Vettenranta, F. Wesenberg, S. Einhorn, M. Heyman (2002)
Deletion of the Ink4-locus (the p16ink4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92Leukemia, 16
E. Paietta (1995)
Proposals for the immunological classification of acute leukemias.Leukemia, 9 12
H. Beverloo (2006)
Inactivation of CDKN2A, CDKN2B and MTAP in childhood B-lineage acute lymphobastic leukemia.Haematologica, 91 7
L. Harewood, H. Robinson, R. Harris, M. Al-Obaidi, G. Jalali, M. Martineau, A. Moorman, N. Sumption, S. Richards, C. Mitchell, C. Harrison, on Parties (2003)
Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 casesLeukemia, 17
In vivo response to initial therapy, as assessed by determination of minimal residual disease (MRD) after 5 and 12 weeks of treatment, has evolved as a strong prognostic factor in children with acute lymphoblastic leukemia (ALL) treated according to the BFM regime. Individual treatment response may be influenced by copy number alterations (CNA) leading to altered gene expression. We aimed to evaluate CNA using high‐resolution array‐comparative genomic hybridization (array‐CGH) in different treatment‐response groups. Leukemic genomic profiles of 25 standard risk (MRD‐SR) and 25 high risk (MRD‐HR) patients were compared. CNAs were found in 46/50 patients (92%). The most significant difference was a gain of 1q23‐qter because of an unbalanced t(1;19), found in 10/25 MRD‐SR patients, but in none of the MRD‐HR patients (P < 0.001). The most frequent CNAs in the MRD‐HR group were deletions of genomic regions harboring the immunoglobulin genes (Ig), e.g., 2p11.2 in 60% of MRD‐HR compared to 28% of MRD‐SR (P = 0.045). Combining all Ig loci, significantly more MRD‐HR than MRD‐SR patients displayed deletions (17:8 patients, P = 0.02). Frequency of other CNAs, such as loss of 9p21 or gains of 21q, did not differ strongly between the two patient groups. This is the first study evaluating the clinical significance of CNA as detected by array‐CGH in childhood ALL and the first to suggest that such analyses may provide clinically important data. This article contains supplementary material available via the Internet at http://www.interscience.wiley.com/jpages/1045‐2257/suppmat. © 2008 Wiley‐Liss, Inc.
Genes, Chromosomes and Cancer – Wiley
Published: Jun 1, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.