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Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters

Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters Cone snails have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in normal and diseased states. A number of these peptides have shown efficacy in vivo, including inhibitors of calcium channels, the norepinephrine transporter, nicotinic acetylcholine receptors, NMDA receptors and neurotensin receptors, with several having undergone pre‐clinical or clinical development for the treatment of pain. IUBMB Life, 56: 89‐93, 2004 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png IUBMB Life Wiley

Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters

Lewis, Richard J.
IUBMB Life , Volume 56 (2) – Feb 1, 2004
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References (1)

Publisher
Wiley Subscription Services, Inc., A Wiley Company
Copyright
Copyright © 2004 International Union of Biochemistry and Molecular Biology
ISSN
1521-6543
eISSN
1521-6551
DOI
10.1080/15216540410001668055
pmid
15085932
Publisher site
See Article on Publisher Site

Abstract

Cone snails have evolved a vast array of peptide toxins for prey capture and defence. These peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in normal and diseased states. A number of these peptides have shown efficacy in vivo, including inhibitors of calcium channels, the norepinephrine transporter, nicotinic acetylcholine receptors, NMDA receptors and neurotensin receptors, with several having undergone pre‐clinical or clinical development for the treatment of pain. IUBMB Life, 56: 89‐93, 2004

Journal

IUBMB Life – Wiley

Published: Feb 1, 2004

Keywords: Calcium channel; sodium channel; norepinephrine transporter; nicotinic acetylcholine receptor; NMDA receptor; neurotensin receptor

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