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G Webb, R Byrd (1994)
Simultaneous differential staining of cartilage and bone without glacial acetic acid, 69
D. Stearns, J. BelBruno, K. Wetterhahn (1995)
A prediction of chromium(III) accumulation in humans from chromium dietary supplementsThe FASEB Journal, 9
A. Bergen, R. Colton, Matthew Percy, Bruce West (1993)
Electrospray mass spectrometric study of [M3O(RCOO)6L3]+ cations (M = chromium, iron; L = H2O, MeOH, py)Inorganic Chemistry, 32
LJ Hopkins, O Ransome‐Kuti, A Majaj (1968)
Improvement of impaired carbogydrate metabolism by chromium(III) in sensitizing infants, 21
P. Whittaker, R. San, J. Clarke, H. Seifried, V. Dunkel (2005)
Mutagenicity of chromium picolinate and its components in Salmonella typhimurium and L5178Y mouse lymphoma cells.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 43 11
Yanjie Sun, K. Mallya, J. Ramirez, J. Vincent (1999)
The biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ decreases plasma cholesterol and triglycerides in rats: towards chromium-containing therapeuticsJBIC Journal of Biological Inorganic Chemistry, 4
C. Gürson, G. Saner (1971)
Effect of chromium on glucose utilization in marasmic protein-calorie malnutrition.The American journal of clinical nutrition, 24 11
J. Vincent (2001)
The bioinorganic chemistry of chromium(III)Polyhedron, 20
N. Chakov, R. Collins, J. Vincent (1999)
A re-investigation the electronic spectra of chromium(III) picolinate complexes and high yield synthesis and characterization of Cr2(μ-OH)2(pic)4·5H2O (Hpic=picolinic acid)Polyhedron, 18
R. Gudi, R. Slesinski, J. Clarke, R. San (2005)
Chromium picolinate does not produce chromosome damage in CHO cells.Mutation research, 587 1-2
W. Glinsmann, W. Mertz (1966)
Effect of trivalent chromium on glucose tolerance.Metabolism: clinical and experimental, 15 6
R. Slesinski, J. Clarke, R. San, R. Gudi (2005)
Lack of mutagenicity of chromium picolinate in the hypoxanthine phosphoribosyltransferase gene mutation assay in Chinese hamster ovary cells.Mutation research, 585 1-2
M. Bailey, J. Boohaker, R. Sawyer, J. Behling, J. Rasco, J. Jernigan, R. Hood, J. Vincent (2006)
Exposure of pregnant mice to chromium picolinate results in skeletal defects in their offspring.Birth defects research. Part B, Developmental and reproductive toxicology, 77 3
R Anderson, M. Polansky, N. Bryden, J Canary (1991)
Supplemental-chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low-chromium diets.The American journal of clinical nutrition, 54 5
A. Earnshaw, B. Figgis, J. Lewis (1966)
Chemistry of polynuclear compounds. Part VI. Magnetic properties of trimeric chromium and iron carboxylatesJournal of The Chemical Society A: Inorganic, Physical, Theoretical
C. Davis, and Royer, J. Vincent (1997)
Synthetic Multinuclear Chromium Assembly Activates Insulin Receptor Kinase Activity: Functional Model for Low-Molecular-Weight Chromium-Binding SubstanceInorganic Chemistry, 36
C. Dillon, P. Lay, A. Bonin, Marian Cholewa, G. Legge (2000)
Permeability, cytotoxicity, and genotoxicity of Cr(III) complexes and some Cr(V) analogues in V79 Chinese hamster lung cells.Chemical research in toxicology, 13 8
Yanjie Sun, Buffie Clodfelder, A. Shute, Turkessa Irvin, J. Vincent (2002)
The biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ decreases plasma insulin, cholesterol, and triglycerides in healthy and type II diabetic rats but not type I diabetic ratsJBIC Journal of Biological Inorganic Chemistry, 7
A. Abraham, B. Brooks, U. Eylath (1992)
The effects of chromium supplementation on serum glucose and lipids in patients with and without non-insulin-dependent diabetes.Metabolism: clinical and experimental, 41 7
E. O'FLAHERTY, B. Kerger, S. Hays, D. Paustenbach (2001)
A physiologically based model for the ingestion of chromium(III) and chromium(VI) by humans.Toxicological sciences : an official journal of the Society of Toxicology, 60 2
D. Hepburn, J. Vincent (2003)
Tissue and subcellular distribution of chromium picolinate with time after entering the bloodstream.Journal of inorganic biochemistry, 94 1-2
C. Davis, J. Vincent (1997)
Chromium oligopeptide activates insulin receptor tyrosine kinase activity.Biochemistry, 36 15
B. Morris, S. Macneil, R. Fraser, T. Gray (1995)
Increased urine chromium excretion in normal pregnancy.Clinical chemistry, 41 10
L. Hopkins, O. Ransome-kuti, A. Majaj (1968)
Improvement of impaired carbohydrate metabolism by chromium 3 in manourished infants.The American journal of clinical nutrition, 21 3
Buffie Clodfelder, Christine Chang, J. Vincent (2004)
Absorption of the biomimetic chromium cation triaqua-μ3-oxo-μ-hexapropionatotrichromium(III) in ratsBiological Trace Element Research, 98
D. Bagchi, S. Stohs, B. Downs, M. Bagchi, H. Preuss (2002)
Cytotoxicity and oxidative mechanisms of different forms of chromium.Toxicology, 180 1
A Earnshaw, B Figgis, J Lewis (1966)
Chemistry of polynuclear compounds. Part IV. Magnetic properties of trimeric chromium and iron compounds
Urmila Shindea, G. Sharma, Yan-Jan Xu, N. Dhalla, R. Goyal (2004)
Insulin sensitising action of chromium picolinate in various experimental models of diabetes mellitus.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements, 18 1
K. Sugden, K. Wetterhahn (1997)
Direct and hydrogen peroxide-induced chromium(V) oxidation of deoxyribose in single-stranded and double-stranded calf thymus DNA.Chemical research in toxicology, 10 12
A. Levina, Gregory Barr-David, R. Codd, P. Lay, N. Dixon, A. Hammershøi, P. Hendry (1999)
In vitro plasmid DNA cleavage by chromium(V) and -(IV) 2-hydroxycarboxylato complexes.Chemical research in toxicology, 12 4
L. Jovanovič, Mario Gutiérrez, C. Peterson (1999)
Chromium supplementation for women with gestational diabetes mellitusJournal of Trace Elements in Experimental Medicine, 12
V. Coryell, D. Stearns (2006)
Molecular analysis of hprt mutations induced by chromium picolinate in CHO AA8 cells.Mutation research, 610 1-2
B. Zachara, Z. Wlodarczyk, M. Masztalerz, A. Adamowicz, J. Gromadzińska, W. Wąsowicz (2007)
Selenium concentrations and glutathione peroxidase activities in blood of patients before and after allogenic kidney transplantationBiological Trace Element Research, 97
J. Speetjens, R. Collins, J. Vincent, S. Woski (1999)
The nutritional supplement chromium(III) tris(picolinate) cleaves DNA.Chemical research in toxicology, 12 6
J. Vincent (2004)
Recent advances in the nutritional biochemistry of trivalent chromiumProceedings of the Nutrition Society, 63
J. Vincent (2009)
Quest for the molecular mechanism of chromium action and its relationship to diabetes.Nutrition reviews, 58 3 Pt 1
R. Anderson, M. Polansky, N. Bryden, E. Roginski, W. Mertz, W. Glinsmann (1983)
Chromium supplementation of human subjects: effects on glucose, insulin, and lipid variables.Metabolism: clinical and experimental, 32 9
G. Webb, R. Byrd (1994)
Simultaneous differential staining of cartilage and bone in rodent fetuses: an alcian blue and alizarin red S procedure without glacial acetic acid.Biotechnic & histochemistry : official publication of the Biological Stain Commission, 69 4
Buffie Clodfelder, Bryan Gullick, H. Lukaski, Y. Neggers, J. Vincent (2005)
Oral administration of the biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ increases insulin sensitivity and improves blood plasma variables in healthy and type 2 diabetic ratsJBIC Journal of Biological Inorganic Chemistry, 10
J. Speetjens, A. Parand, M. Crowder, J. Vincent, S. Woski (1999)
LOW-MOLECULAR-WEIGHT CHROMIUM-BINDING SUBSTANCE AND BIOMIMETIC CR3O(O2CCH2CH3)6(H2O)3+ DO NOT CLEAVE DNA UNDER PHYSIOLOGICALLY-RELEVANT CONDITIONSPolyhedron, 18
D. Stearns, Stacey Silveira, K. Wolf, April Luke (2002)
Chromium(III) tris(picolinate) is mutagenic at the hypoxanthine (guanine) phosphoribosyltransferase locus in Chinese hamster ovary cells.Mutation research, 513 1-2
R. Press, J. Geller, G. Evans (1990)
The effect of chromium picolinate on serum cholesterol and apolipoprotein fractions in human subjects.The Western journal of medicine, 152 1
D. Stearns, J. Wise, S. Patierno, K. Wetterhahn (1995)
Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells 1The FASEB Journal, 9
J. Vincent (2000)
Elucidating a biological role for chromium at a molecular level.Accounts of chemical research, 33 7
BACKGROUND: Chromium(III) is generally thought to be an essential trace element that allows for proper glucose metabolism. However, chromium(III) picolinate, Cr(pic)3, a popular dietary supplement form of chromium, has been shown to be capable of generating hydroxyl radicals and oxidative DNA damage in rats. The cation [Cr3O(O2CCH2CH3)6(H2O)3]+, Cr3, has been studied as an alternative supplemental source of chromium. It has been shown to increase insulin sensitivity and lower glycated hemoglobin levels in rats, making it attractive as a potential therapeutic treatment for gestational diabetes. To date, no studies have been published regarding the safety of Cr3 supplementation to a developing fetus. METHODS: From gestation days (GD) 6–17, mated CD‐1 female mice were fed diets delivering either 25 mg Cr/kg/day as Cr(pic)3, 3.3 or 26 mg Cr/kg/day as Cr3, or the diet only to determine if Cr3 could cause developmental toxicity. Dams were sacrificed on GD 17, and their litters were examined for adverse effects. RESULTS: No signs of maternal toxicity were observed. No decrease in fetal weight or significantly increased incidence of skeletal defects was observed in the Cr3 or Cr(pic)3 exposed fetuses compared to the controls. CONCLUSION: Maternal exposure to either Cr(pic)3 or Cr3 at the dosages employed did not appear to cause deleterious effects to the developing offspring in mice. Birth Defects Res (Part B), 80:1–5, 2007. © 2007 Wiley‐Liss, Inc.
Birth Defects Research Part B – Wiley
Published: Feb 1, 2008
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