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J. Rey, M. Bello, J. Campos, M. Kusak, S. Moreno, J. Benítez (1987)
Deletion 3p in two lung adenocarcinomas metastatic to the brain.Cancer genetics and cytogenetics, 25 2
I. Miura, J. Siegfried, J. Resau, S. Keller, Jian‐Yuan Zhou, J. Testa (1990)
Chromosome alterations in 21 non‐small cell lung carcinomasGenes, 2
(1984)
Establishment and characterisation
J. Trent, F. Meyskens, S. Salmon, K. Ryschon, S. Leong, J. Davis, D. McGee (1990)
Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma.The New England journal of medicine, 322 21
M. Bello, J. Rey (1990)
Chromosome aberrations in metastatic ovarian cancer: Relationship with abnormalities in primary tumorsInternational Journal of Cancer, 45
G. Nicolson (1987)
Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.Cancer research, 47 6
G. Sozzi, M. Miozzo, E. Tagliabue, C. Calderone, L. Lombardi, S. Pilotti, U. Pastorino, M. Pierotti, G. Porta (1991)
Cytogenetic abnormalities and overexpression of receptors for growth factors in normal bronchial epithelium and tumor samples of lung cancer patients.Cancer research, 51 1
K. Alitalo, M. Schwab (1986)
Oncogene amplification in tumor cells.Advances in cancer research, 47
Joseph Testa, Jill Siegfried (1992)
Chromosome abnormalities in human non-small cell lung cancer.Cancer research, 52 9 Suppl
F. Waldman, Peter Carroll, R. Kerschmann, Michael Cohen, Frederick Field, B. Mayall (1991)
Centromeric copy number of chromosome 7 is strongly correlated with tumor grade and labeling index in human bladder cancer.Cancer research, 51 14
P. Nowell (1989)
Chromosomal and molecular clues to tumor progression.Seminars in oncology, 16 2
P. Loh, G. Clamon, R. Robinson, M. White, B. Hukku, N. Rossi, W. Peterson (1984)
Establishment and characterization of four new human non-small cell lung cancer cell lines.Cancer research, 44 8
Yao‐Shan Fan, Pu Li (1987)
Cytogenetic studies of four human lung adenocarcinoma cell lines.Cancer genetics and cytogenetics, 26 2
M. Erdel, Wolfgang Peter, Eberhard Spiess, Günter Trefz, Werner Ebert (1990)
Karyotypic characterization of established cell lines derived from a squamous cell carcinoma and an adenocarcinoma of human lung cancers.Cancer genetics and cytogenetics, 49 2
J. Whang‐Peng, T. Knutsen, A. Gazdar, S. Steinberg, H. Oie, I. Linnoila, J. Mulshine, M. Nau, J. Minna (1991)
Nonrandom structural and numerical chromosome changes in non‐small‐cell lung cancerGenes, 3
Lore Zech, J. Bergh, Kenneth Nilsson (1985)
Karyotypic characterization of established cell lines and short-term cultures of human lung cancers.Cancer genetics and cytogenetics, 15 3-4
G. Poste, I. Fidler (1980)
The pathogenesis of cancer metastasisNature, 283
Y. Jin, N. Mandahl, S. Heim, H. Schüller, F. Mitelman (1988)
Isochromosomes i(8q) or i(9q) in three adenocarcinomas of the lung.Cancer genetics and cytogenetics, 33 1
J. Liang, R. Kurzrock, J. Gutterman, G. Gallick (1986)
Trisomy 12 correlates with elevated expression of p21 ras in a human adenosquamous carcinoma of the lung.Cancer genetics and cytogenetics, 23 2
Jin-Sook Lee, S. Pathak, V. Hopwood, B. Tomasovic, T. Mullins, F. Baker, G. Spitzer, J. Neidhart (1987)
Involvement of chromosome 7 in primary lung tumor and nonmalignant normal lung tissue.Cancer research, 47 23
F. O'Malley, O. Garson (1985)
Chronic granulocytic leukemia: Correlation of elastic transformation type with karyotypic evolutionAmerican Journal of Hematology, 20
J. Teyssier, R. Sadrin, J. Nõu, G. Bureau, J. Adnet, F. Bajolle, F. Pigeon (1985)
Trisomy 7 in a lung carcinoid tumor: precocious index of malignant transformation?Cancer genetics and cytogenetics, 15 3-4
A. Hopman, O. Moesker, A. Smeets, R. Pauwels, G. Vooijs, F. Ramaekers (1991)
Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization.Cancer research, 51 2
R. Lukeis, L. Irving, M. Garson, S. Hasthorpe (1990)
Cytogenetics of non‐small cell lung cancer: Analysis of consistent non‐random abnormalitiesGenes, 2
A. Olumi, Y. Tsai, P. Nichols, D. Skinner, Delver Cain, LEON Bender, Peter Jones (1990)
Allelic loss of chromosome 17p distinguishes high grade from low grade transitional cell carcinomas of the bladder.Cancer research, 50 21
Greco Fa, H. Jd (1989)
The management of patients with adenocarcinoma and poorly differentiated carcinoma of unknown primary site.Seminars in Oncology, 16
P. Cagle, L. Taylor, M. Schwartz, I. Ramzy, F. Elder (1989)
Cytogenetic abnormalities common to adenocarcinoma metastatic to the pleura.Cancer genetics and cytogenetics, 39 2
M. Herlyn, Gloria Balaban, J. Bennicelli, D. Guerry, Ruth Halaban, D. Herlyn, David Elder, Gerd Maul, Zenon Steplewski, Peter Nowell, Wallace Clark, Hilary. Koprowski (1985)
Primary melanoma cells of the vertical growth phase: similarities to metastatic cells.Journal of the National Cancer Institute, 74 2
E. Viégas-Péquignot, A. Flüry-Herard, H. Crémoux, C. Chlecq, J. Bignon, B. Dutrillaux (1990)
Recurrent chromosome aberrations in human lung squamous cell carcinomas.Cancer genetics and cytogenetics, 49 1
M. Seabright (1971)
A rapid banding technique for human chromosomes.Lancet, 2 7731
A. Leone, U. Flatow, C. King, Mary Sandeen, I. Margulies, L. Liotta, P. Steeg (1991)
Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm3-transfected melanoma cellsCell, 65
B. Vogelstein, E. Fearon, S. Hamilton, S. Kern, Antonette Preisinger, M. Leppert, Y. Nakamura, R. White, A. Smits, J. Bos (1988)
Genetic alterations during colorectal-tumor development.The New England journal of medicine, 319 9
A cytogenetic study of pleural effusions (PE) containing metastatic or invasive tumor cells from 11 patients with non‐small cell lung cancer (NSCLC) (3 squamous cell carcinomas (SQC) and 8 adenocarcinomas (ADC) including 1 giant cell variant) was performed to identify non‐random chromosome abnormalities. Numerical abnormalities seen in ≥ 30% of cases included gain of chromosomes 7 and 20, and loss of chromosomes 4, 9, 10, 13, 15, 16, 18, 19, 21, and 22. The most frequent structural abnormality involved rearrangement in 1p with breakpoints clustering at 1p10‐p13. Other recurrent breakpoint regions, seen in ≥ 30% of cases, occurred in chromosome regions 3p10‐p21, 3q11‐q25, 6p11‐p25, 6q13‐q23, 7q11‐q36, 9q32‐q34, 11p11‐p13, 11q13‐q24, 13p/14p and/or 15p, 17p and 19p, with, in particular, apparent loss of 6q21‐q27, 3p21‐p26, 7q21‐q22, 9p22‐p24 (shortest regions of common overlap) and 17p. There was also recurrent gain of 1q23‐q44, 8q13‐q24, and 11q13‐q23. These abnormalities were not restricted to a particular histological subtype, with the exception of + 8 and a breakpoint in 9q32‐q34, which were seen only in ADC. The 9q32‐q34 breakpoint observed in 4 ADC PE (including 1 giant cell variant) represents a new observation in NSCLC. These findings, when compared to those reported for primary NSCLC indicate cytogenetic differences between the two which may be associated with pleural invasion of NSCLC. © 1993 Wiley‐Liss, Inc.
Genes, Chromosomes and Cancer – Wiley
Published: Dec 1, 1993
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