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Journals PROTEOMICS Volume 11 Issue 10

Increasing evidence suggests that dendritic cells (DCs) and oxidized low‐density lipoprotein (ox‐LDL) participate in atherosclerosis. However, few data on the molecular mechanisms of this process are available. To address this question, we used iTRAQ labeling followed by LC‐MS/MS analysis to identify many proteins that changed markedly during the maturation of dendritic cells stimulated with ox‐LDL. Among a total of 781 identified proteins, 93 were upregulated and 100 were downregulated. The major and significant changes in upregulated proteins were that ox‐LDL not only affected the levels of intracellular cathepsins G, Z, D and S, but also significantly enhanced cathepsin S secretion by the treated cells. Our results may provide clues for a more comprehensive understanding the pathogenesis of atherosclerosis.

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Changes in proteomics profile during maturation of marrow‐derived dendritic cells treated with oxidized low‐density lipoprotein

More Info
  • Publisher WILEY‐VCH Verlag
  • Copyright Copyright © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
  • ISSN 1615-9853
  • eISSN 1615-9861
  • D.O.I. 10.1002/pmic.201000658
  • Publisher site Get PDF  

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