Access the full text.
Sign up today, get DeepDyve free for 14 days.
L. Berkman, C. Berkman, S. Kasl, D. Freeman, L. Leo, A. Ostfeld, J. Cornoni-Huntley, J. Brody (1986)
Depressive symptoms in relation to physical health and functioning in the elderly.American journal of epidemiology, 124 3
C. Gold, B. Malmberg, G. Mcclearn, N. Pedersen, S. Berg (2002)
Gender and health: a study of older unlike-sex twins.The journals of gerontology. Series B, Psychological sciences and social sciences, 57 3
(1999)
Genetics and mental disorders. National Institute of Mental Health's Genetics Workgroup.Biological psychiatry, 45 5
M. Gatz, N. Pedersen, R. Plomin, J. Nesselroade, G. Mcclearn (1992)
Importance of shared genes and shared environments for symptoms of depression in older adults.Journal of abnormal psychology, 101 4
C. Johansson, Mårten Jansson, L. Linnér, Q. Yuan, N. Pedersen, D. Blackwood, N. Barden, J. Kelsoe, M. Schalling (2001)
Genetics of affective disordersEuropean Neuropsychopharmacology, 11
S. Barondes (1999)
Report of the National Institute of Mental Health’s Genetics Workgroup IntroductionBiological Psychiatry, 45
C. Bradley, R. Blakely (1997)
Alternative Splicing of the Human Serotonin Transporter GeneJournal of Neurochemistry, 69
M. Weissman, G. Klerman (1977)
The chronic depressive in the community: unrecognized and poorly treated.Comprehensive psychiatry, 18 6
Roland Bunzel, Ingmar Blümcke, S. Cichon, S. Normann, Johannes Schramm, P. Propping, M. Nöthen (1998)
Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain.Brain research. Molecular brain research, 59 1
P. Burvill, W. Hall (1994)
Predictors of increased mortality in elderly depressed patientsInternational Journal of Geriatric Psychiatry, 9
Sonnenberg Cm, Beekman Atf, Deeg Djh., T. Van (2000)
Sex differences in late‐life depressionActa Psychiatrica Scandinavica, 101
G. Mcclearn, B. Johansson, S. Berg, N. Pedersen, F. Ahern, S. Petrill, R. Plomin (1997)
Substantial genetic influence on cognitive abilities in twins 80 or more years old.Science, 276 5318
J. Veenstra-VanderWeele, G. Anderson, E. Cook (2000)
Pharmacogenetics and the serotonin system: initial studies and future directions.European journal of pharmacology, 410 2-3
A. Beekman, D. Deeg, T. Tilburg, Jan Smit, C. Hooijer, W. Tilburg (1995)
Major and minor depression in later life: a study of prevalence and risk factors.Journal of affective disorders, 36 1-2
(1992)
Depressive symptoms in older adults: Predispositions, resources, and life experiences
P. Lichtenstein, U. Faire, B. Floderus, M. Svartengren, P. Svedberg, N. Pedersen (2002)
The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studiesJournal of Internal Medicine, 252
V. Arango, M. Underwood, J. Mann (1992)
Alterations in Monoamine Receptors in the Brain of Suicide VictimsJournal of Clinical Psychopharmacology, 12
(1986)
Use of the CES-D with older adults
M. Owen, Peter Holmans, P. McGuffin (1997)
Association studies in psychiatric geneticsMolecular Psychiatry, 2
T. Kato, G. Winokur, W. Coryell, M. Keller, J. Endicott, J. Rice (1996)
Parent-of-origin effect in transmission of bipolar disorder.American journal of medical genetics, 67 6
Nancy Pedersen, G. Mcclearn, R. Plomin, J. Nesselroade, Stig Berg, U. Defaire (1991)
The Swedish Adoption Twin Study of Aging: an update.Acta geneticae medicae et gemellologiae, 40 1
M. McGue, K. Christensen, K. Christensen (1997)
Genetic and environmental contributions to depression symptomatology: evidence from Danish twins 75 years of age and older.Journal of abnormal psychology, 106 3
A. Heils, A. Teufel, S. Petri, G. Stöber, P. Riederer, D. Bengel, K. Lesch (1996)
Allelic Variation of Human Serotonin Transporter Gene ExpressionJournal of Neurochemistry, 66
F. Biver, D. Wikler, F. Lotstra, P. Damhaut, S. Goldman, J. Mendlewicz (1997)
Serotonin 5-HT2 receptor imaging in major depression: focal changes in orbito-insular cortexBritish Journal of Psychiatry, 171
M. Gatz, B. Johansson, N. Pedersen, S. Berg, C. Reynolds (1993)
A Cross-National Self-Report Measure of Depressive SymptomatologyInternational Psychogeriatrics, 5
R. Duman, G. Heninger, Eric Nestler (1997)
A molecular and cellular theory of depression.Archives of general psychiatry, 54 7
(2002)
Life events, health, depressive symptoms, and aging
D. Carmelli, G. Swan, M. Kelly‐Hayes, P. Wolf, T. Reed, B. Miller (2000)
Longitudinal changes in the contribution of genetic and environmental influences to symptoms of depression in older male twins.Psychology and aging, 15 3
S. Blairy, I. Massat, L. Staner, O. Bon, S. Gestel, C. Broeckhoven, C. Hilger, F. Hentges, D. Souery, J. Mendlewicz (2000)
5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait.American journal of medical genetics, 96 3
K. Lesch, R. Mössner (1998)
Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?Biological Psychiatry, 44
M. Arranz, J. Erdmann, G. Kirov, M. Rietschel, Monsheel Sodhi, M. Albus, D. Ball, W. Maier, N. Davies, E. Franzek, I. Abusaad, B. Weigelt, R. Murray, D. Shimron-Abarbanell, R. Kerwin, P. Propping, P. Sham, M. Nöthen, D. Collier (1997)
5-HT2A receptor and bipolar affective disorder: association studies in affected patientsNeuroscience Letters, 224
V. Murphy, L. Mynett-Johnson, E. Claffey, D. Shields, P. Mckeon (2001)
No association between 5HT-2A and bipolar disorder irrespective of genomic imprinting.American journal of medical genetics, 105 5
I. Lucki (1998)
The spectrum of behaviors influenced by serotoninBiological Psychiatry, 44
L. Nordfors, Mårten Jansson, G. Sandberg, C. Lavebratt, S. Sengul, M. Schalling, P. Arner (2002)
Large‐scale genotyping of single nucleotide polymorphisms by Pyrosequencing™ and validation against the 5′nuclease (Taqman®) assayHuman Mutation, 19
P. Sullivan, M. Neale, K. Kendler (2000)
Genetic epidemiology of major depression: review and meta-analysis.The American journal of psychiatry, 157 10
C. Minov, T. Baghai, C. Schüle, Peter Zwanzger, Markus Schwarz, P. Zill, Rainer Rupprecht, B. Bondy (2001)
Serotonin-2A-receptor and -transporter polymorphisms: Lack of association in patients with major depressionEuropean Neuropsychopharmacology, 11
(2002)
Unpublished doctoral dissertation, University of Southern California
M. Yates, A. Leake, J. Candy, A. Fairbairn, I. McKeith, I. Ferrier (1990)
5HT2 receptor changes in major depressionBiological Psychiatry, 27
I. Massat, D. Souery, O. Lipp, S. Blairy, G. Papadimitriou, D. Dikeos, M. Ackenheil, S. Fuchshuber, C. Hilger, R. Kaneva, V. Milanova, G. Verheyen, P. Raeymaekers, L. Staner, L. Oruč, M. Jakovljevič, A. Serretti, F. Macciardi, C. Broeckhoven, J. Mendlewicz (2000)
A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder.American journal of medical genetics, 96 2
C. Lambotte, H. Husquinet, G. Hougardy, P. Mambourg, J. Bertrand (1976)
Genetics and mental disordersBiological Psychiatry, 45
J. Veijola, P. Puukka, V. Lehtinen, J. Moring, T. Lindholm, E. Väisänen (1998)
Sex differences in the association between childhood experiences and adult depressionPsychological Medicine, 28
J. Gallo, P. Rabins, C. Lyketsos, A. Tien, J. Anthony (1997)
Depression Without Sadness: Functional Outcomes of Nondysphoric Depression in Later LifeJournal of the American Geriatrics Society, 45
J. Kornberg, J. Brown, A. Sadovnick, R. Remick, P. Keck, S. McElroy, M. Rapaport, P. Thompson, J. Kaul, C. Vrabel, S. Schommer, T. Wilson, D. Pizzuco, S. Jameson, L. Schibuk, J. Kelsoe (2000)
Evaluating the parent-of-origin effect in bipolar affective disorder. Is a more penetrant subtype transmitted paternally?Journal of affective disorders, 59 3
L. Radloff (1977)
The CES-D ScaleApplied Psychological Measurement, 1
L. Radloff
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population — Source link
B. Mahieu, D. Souery, O. Lipp, K. Mendelbaum, G. Verheyen, V. Maertelaer, C. Broeckhoven, J. Mendlewicz (1997)
No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphismPsychiatry Research, 70
L. Radloff, L. Teri (1986)
6/Use of the Center for Epidemiological Studies-Depression Scale with Older AdultsClinical Gerontologist, 5
G. Turecki, R. Briére, K. Dewar, T. Antonetti, A. Lesage, M. Séguin, N. Chawky, C. Vanier, M. Alda, R. Joober, C. Benkelfat, G. Rouleau (1999)
Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide.The American journal of psychiatry, 156 9
E. Jönsson, M. Nöthen, J. Gustavsson, C. Berggård, Roland Bunzel, K. Forslund, G. Rylander, M. Mattila‐Evenden, P. Propping, M. Åsberg, G. Sedvall (2001)
No association between serotonin 2A receptor gene variants and personality traitsPsychiatric Genetics, 11
Hai-yin Zhang, T. Ishigaki, K. Tani, Kevin Chen, J. Shih, K. Miyasato, K. Ohara, K. Ohara (1997)
Serotonin2A receptor gene polymorphism in mood disordersBiological Psychiatry, 41
L. Nordfors, Mårten Jansson, G. Sandberg, C. Lavebratt, S. Sengul, M. Schalling, P. Arner (2002)
Large-scale genotyping of single nucleotide polymorphisms by Pyrosequencingtrade mark and validation against the 5'nuclease (Taqman((R))) assay.Human mutation, 19 4
M. Ronaghi, M. Uhlén, P. Nyrén (1998)
A Sequencing Method Based on Real-Time PyrophosphateScience, 281
M. Rao, B. Hawellek, A. Papassotiropoulos, A. Deister, C. Frahnert (1998)
Upregulation of the Platelet Serotonin2A Receptor and Low Blood Serotonin in Suicidal Psychiatric PatientsNeuropsychobiology, 38
(1992)
Depression and dementia studies in twins
The aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate SNPs in the serotonin system: one in the 5‐HTR2A gene promotor (−1438 G/A) and one in the 5‐HT transporter gene (−925 C/A). DNA from a population‐based Swedish twin sample (N = 1,592; mean age = 73) was genotyped using Pryosequencing™. An association was found between the 5‐HTR2A gene promotor polymorphism and depressed mood (OR: 1.5, CI: 1.1–2.1) for the A/A genotype in the total sample. When the sample was analyzed by gender, a significant association (OR: 2.4, CI: 1.4–4.4) was found for males and the A/A genotype, but not for females. The 5‐HT transporter gene was not associated with depressed mood in this elderly population. These results suggest that there might be different genetic mechanisms for males and females contributing to the development of depressed mood in the elderly. © 2003 Wiley‐Liss, Inc.
American Journal of Medical Genetics – Wiley
Published: Jul 1, 2003
Keywords: serotonin; depressed mood; SNP
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.