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Association between depressed mood in the elderly and a 5‐HTR2A gene variant

Association between depressed mood in the elderly and a 5‐HTR2A gene variant The aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate SNPs in the serotonin system: one in the 5‐HTR2A gene promotor (−1438 G/A) and one in the 5‐HT transporter gene (−925 C/A). DNA from a population‐based Swedish twin sample (N = 1,592; mean age = 73) was genotyped using Pryosequencing™. An association was found between the 5‐HTR2A gene promotor polymorphism and depressed mood (OR: 1.5, CI: 1.1–2.1) for the A/A genotype in the total sample. When the sample was analyzed by gender, a significant association (OR: 2.4, CI: 1.4–4.4) was found for males and the A/A genotype, but not for females. The 5‐HT transporter gene was not associated with depressed mood in this elderly population. These results suggest that there might be different genetic mechanisms for males and females contributing to the development of depressed mood in the elderly. © 2003 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Wiley

Association between depressed mood in the elderly and a 5‐HTR2A gene variant

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References (54)

Publisher
Wiley
Copyright
Copyright © 2003 Wiley‐Liss, Inc., A Wiley Company
ISSN
0148-7299
eISSN
1096-8628
DOI
10.1002/ajmg.b.20016
pmid
12815744
Publisher site
See Article on Publisher Site

Abstract

The aim of this study was to investigate any possible association between depressed mood in the elderly and two candidate SNPs in the serotonin system: one in the 5‐HTR2A gene promotor (−1438 G/A) and one in the 5‐HT transporter gene (−925 C/A). DNA from a population‐based Swedish twin sample (N = 1,592; mean age = 73) was genotyped using Pryosequencing™. An association was found between the 5‐HTR2A gene promotor polymorphism and depressed mood (OR: 1.5, CI: 1.1–2.1) for the A/A genotype in the total sample. When the sample was analyzed by gender, a significant association (OR: 2.4, CI: 1.4–4.4) was found for males and the A/A genotype, but not for females. The 5‐HT transporter gene was not associated with depressed mood in this elderly population. These results suggest that there might be different genetic mechanisms for males and females contributing to the development of depressed mood in the elderly. © 2003 Wiley‐Liss, Inc.

Journal

American Journal of Medical GeneticsWiley

Published: Jul 1, 2003

Keywords: serotonin; depressed mood; SNP

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