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Application of Gibbs' Rule and a Simple Pathway Method to Microbial Stoichiometry

Application of Gibbs' Rule and a Simple Pathway Method to Microbial Stoichiometry The power of metabolic pathway stoichiometry for applications in bioreactor monitoring and control, in terms of the degrees of freedom, the calculation of reaction rates, and the validity of pathway models, is analyzed by using Gibbs' rule of stoichiometry. The pathway stoichiometry has significant advantages over the macroscopic balance methods when the number of independent reactions is not at its maximum. When the number of reactions is at the maximum, the power of the pathway stoichiometry is very much limited, and it should be used with caution. A simple method is also proposed to derive all possible independent stoichiometric constraints from the metabolic pathways. For most practical fermentations, the proposed method is much easier to use than the existing methods in the literature. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biotechnology Progress Wiley

Application of Gibbs' Rule and a Simple Pathway Method to Microbial Stoichiometry

Biotechnology Progress , Volume 4 (2) – Jun 1, 1988

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References (18)

Publisher
Wiley
Copyright
Copyright © 1988 American Institute of Chemical Engineers (AIChE)
ISSN
8756-7938
eISSN
1520-6033
DOI
10.1002/btpr.5420040206
Publisher site
See Article on Publisher Site

Abstract

The power of metabolic pathway stoichiometry for applications in bioreactor monitoring and control, in terms of the degrees of freedom, the calculation of reaction rates, and the validity of pathway models, is analyzed by using Gibbs' rule of stoichiometry. The pathway stoichiometry has significant advantages over the macroscopic balance methods when the number of independent reactions is not at its maximum. When the number of reactions is at the maximum, the power of the pathway stoichiometry is very much limited, and it should be used with caution. A simple method is also proposed to derive all possible independent stoichiometric constraints from the metabolic pathways. For most practical fermentations, the proposed method is much easier to use than the existing methods in the literature.

Journal

Biotechnology ProgressWiley

Published: Jun 1, 1988

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