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G. Kaur, S. Carnelio, N. Rao, L. Rao (2009)
Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes: an immunohistochemical study.Indian journal of dental research : official publication of Indian Society for Dental Research, 20 1
D. Karadaglic, T. Wilson (2008)
Image formation in structured illumination wide-field fluorescence microscopy.Micron, 39 7
C. Downer, P. Speight (1993)
E-cadherin expression in normal, hyperplastic and malignant oral epithelium.European journal of cancer. Part B, Oral oncology, 29B 4
U. Moll, N. Slade (2004)
p63 and p73: roles in development and tumor formation.Molecular cancer research : MCR, 2 7
C. Wong, N. Chen, C. Sheppard (2006)
Study on potential of structured illumination microscopy utilizing digital micromirror device for endoscopy purpose2006 International Symposium on Biophotonics, Nanophotonics and Metamaterials
A. Hosoya, Jong‐Min Lee, Sung-Won Cho, Ji-Youn Kim, N. Shinozaki, T. Shibahara, M. Shimono, Han-Sung Jung (2008)
Morphological evidence of basal keratinocyte migration during the re-epithelialization processHistochemistry and Cell Biology, 130
M. Gustafsson, L. Shao, P. Carlton, C. Wang, I. Golubovskaya, W. Cande, D. Agard, D. Agard, J. Sedat (2008)
Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination.Biophysical journal, 94 12
M. Wheelock, P. Jensen (1992)
Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherinThe Journal of Cell Biology, 117
R. Das, M. Pal, A. Barui, R. Paul, C. Chakraborty, A. Ray, S. Sengupta, J. Chatterjee (2010)
Assessment of malignant potential of oral submucous fibrosis through evaluation of p63, E-cadherin and CD105 expressionJournal of Clinical Pathology, 63
M. Diniz-Freitas, T. García-Caballero, J. Antúnez-López, J. Gándara-Rey, A. García-García (2006)
Reduced E-cadherin expression is an indicator of unfavourable prognosis in oral squamous cell carcinoma.Oral oncology, 42 2
R. Dellavalle, P. Walsh, A. Marchbank, T. Grayson, L. Su, E. Parker, J. DeGregori, Kristi Penheiter, M. Aszterbaum, E. jr, L. Lee (2002)
CUSP/p63 expression in basal cell carcinomaExperimental Dermatology, 11
Lionel Larue, Christopher Antos, Stefan Butz, Otmar Huber, V. Delmas, Mara Dominis, R. Kemler (1996)
A role for cadherins in tissue formation.Development, 122 10
Precise histopathological localization of E‐cadherin and p63 is of immense importance in understanding the integrity of oral mucosal stratified epithelium in normal and diseased conditions. Necessarily immunohistochemical imaging should have minimum bleaching impact on the dyes and ability to produce clear and crisp images. Here ApoTome provides an alternative with metal halide light source and structured illumination under the assistance of grids, along with integrated image processing modality to generate crisp images with digital interface. The current study demonstrates the applicability of such microscopic system in capturing fluorescence images of immunohistochemical sections of normal and precancerous biopsies in respect to the expression of p63 and E‐cadherin in the epithelial cells. The ApoTome images localize the nuclear and membranous expressions of p63 and E‐cadherin, respectively, with remarkable specificity. The findings on E‐cadherin expression have enormous diagnostic significance as these images clearly differentiate the early and advanced stages of oral submucous fibrosis based on their cytoplasmic and membranous location. Thus, this study clearly depicts a remarkable performance of ApoTome with diagnostic significance.
Biotechnology Journal – Wiley
Published: May 1, 2012
Keywords: ; ; ; ;
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