Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Singer, Wolfgang Godicke, S. Voigt, Irmgard Hajdu, M. Weiss (1985)
Postprandial hyperinsulinemia in patients with mild essential hypertension.Hypertension, 7 2
R. Ziegler, U. Deutschle, F. Raue (1984)
Calcitonin in human pathophysiology.Hormone research, 20 1
G. Reaven, B. Hoffman (1987)
A ROLE FOR INSULIN IN THE AETIOLOGY AND COURSE OF HYPERTENSION?The Lancet, 330
L. Lissner, C. Bengtsson, L. Lapidus, K. Kristjánsson, H. Wedel (1992)
Fasting insulin in relation to subsequent blood pressure changes and hypertension in women.Hypertension, 20 6
E. Ferrannini, G. Buzzigoli, R. Bonadonna, M. Giorico, M. Oleggini, L. Graziadei, R. Pedrinelli, L. Brandi, S. Bevilacqua (1987)
Insulin resistance in essential hypertension.The New England journal of medicine, 317 6
R. Carretta, B. Fabris, F. Fischetti, Mirella Costantini, F. Biasi, S. Muiesan, M. Bardelli, F. Vran, L. Campanacci (1989)
Reduction of blood pressure in obese hyperinsulinaemic hypertensive patients during somatostatin infusion.Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 7 6
P. Dégano, R. Silvestre, M. Salas, E. Peiró, J. Marco (1993)
Amylin inhibits glucose-induced insulin secretion in a dose-dependent manner. Study in the perfused rat pancreasRegulatory Peptides, 43
C. Moore, G. Cooper (1991)
Co-secretion of amylin and insulin from cultured islet beta-cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents.Biochemical and biophysical research communications, 179 1
L. Skeggs, F. Dorer, K. Lentz, J. Kahn, S. Emancipator (1985)
A new mechanism in one-kidney, one clip hypertension.Hypertension, 7 1
Zhi-li Wang, W. Bennet, M. Ghatei, P. Byfield, David Smith, S. Bloom (1993)
Influence of Islet Amyloid Polypeptide and the 8–37 Fragment of Islet Amyloid Polypeptide on Insulin Release From Perifused Rat IsletsDiabetes, 42
S. Haffner, E. Ferrannini, H. Hazuda, M. Stern (1992)
Clustering of cardiovascular risk factors in confirmed prehypertensive individuals.Hypertension, 20 1
A. Young, T. Rink, M. Wang (1993)
Dose response characteristics for the hyperglycemic, hyperlactemic, hypotensive and hypocalcemic actions of amylin and calcitonin gene-related peptide-I (CGRP alpha) in the fasted, anaesthetized rat.Life sciences, 52 21
K. Finta, A. Rocchini, C. Moorehead, J. Key, V. Katch (1992)
Urine sodium excretion in response to an oral glucose tolerance test in obese and nonobese adolescents.Pediatrics, 90 3
A. Gómez-Foix, J. Rodríguez-Gil, J. Guinovart (1991)
Anti-insulin effects of amylin and calcitonin-gene-related peptide on hepatic glycogen metabolism.The Biochemical journal, 276 ( Pt 3)
P. Briffeuil, T. Thu, J. Kolanowski (1992)
Reappraisal of the role of insulin on sodium handling by the kidney: effect of intrarenal insulin infusion in the dogEuropean Journal of Clinical Investigation, 22
N. Beischer, J. Oats, O. Henry, M. Sheedy, J. Walstab (1991)
Incidence and Severity of Gestational Diabetes Mellitus According to Country of Birth in Women Living in AustraliaDiabetes, 40
M. Modan, H. Halkin, S. Almog, A. Lusky, A. Eshkol, M. Shefi, A. Shitrit, Z. Fuchs (1985)
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.The Journal of clinical investigation, 75 3
K. Landin-Wilhelmsen (1992)
Metformin and blood pressureJournal of Clinical Pharmacy and Therapeutics, 17
Y. Izumi, M. Honda, M. Tsuchiya, Yasuhisa Ueda, M. Hatano (1980)
Effect of somatostatin on plasma renin activity and blood pressure in patients with essential hypertension.Endocrinologia japonica, 27 4
G. Reaven, R. Miller (1968)
Study of the Relationship Between Glucose and Insulin Responses to an Oral Glucose Load in ManDiabetes, 17
E. Ferrannini, S. Haffner, M. Stern (1990)
Essential Hypertension: An Insulin‐Resistant StateJournal of Cardiovascular Pharmacology, 15
S. Suzuki, M. Murakami, S. Abe, Y. Satoh, S. Shintani, J. Ishizuka, K. Suzuki, J. Thompson, T. Toyota (1992)
The effects of amylin on insulin secretion from Rin m5F cells and glycogen synthesis and lipogenesis in rat primary cultured hepatocytes.Diabetes research and clinical practice, 15 1
G. Clementi, E. Rapisarda, C. Fiore, A. Prato, M. Amico-Roxas, C. Millia, R. Bernardini, S. Maugeri, U. Scapagnini (1986)
Effects of salmon calcitonin on plasma renin activity and systolic blood pressure in the ratNeuroscience Letters, 66
A. Carmona, R. Freedland (1989)
Comparison among the lipogenic potential of various substrates in rat hepatocytes: the differential effects of fructose-containing diets on hepatic lipogenesis.The Journal of nutrition, 119 9
T. Stephens, W. Heath, Ronald Hermeling (1991)
Presence of Liver CGRP/Amylin Receptors in Only Nonparenchymal Cells and Absence of Direct Regulation of Rat Liver Glucose Metabolism by CGRP/AmylinDiabetes, 40
M. May, M. Lim-Abrahan, I. Brown, A. Garber (1985)
Hyporeninemic hypoaldosteronism. New associations.Archives of internal medicine, 145 8
M. Kogire, J. Ishizuka, J. Thompson, G. Greeley (1991)
Inhibitory Action of Islet Amyloid Polypeptide and Calcitonin Gene‐related Peptide on Release of Insulin from the Isolated Perfused Rat PancreasPancreas, 6
J. Hall, M. Brands, S. Kivlighn, H. Mizelle, D. Hildebrandt, C Gaillard (1990)
Chronic hyperinsulinemia and blood pressure. Interaction with catecholamines?Hypertension, 15 5
C. Roehrborn, S. Zoppi, J. Gruber, C. Wilson, M. McPhaul (1992)
Expression and characterization of full-length and partial human androgen receptor fusion proteins. Implications for the production and applications of soluble steroid receptors in Escherichia coliMolecular and Cellular Endocrinology, 84
M. Murakami, H. Suzuki, H. Nakamoto, Y. Kageyama, M. Naitoh, Y. Sakamaki, T. Saruta (1991)
Calcitonin gene-related peptide modulates adrenal hormones in conscious dogs.Acta endocrinologica, 124 3
S. Efendić, R. Luft, A. Wajngot (1984)
Aspects of the pathogenesis of type 2 diabetes.Endocrine reviews, 5 3
A. Young, Pam Carlo, P. Smith, D. Wolfe‐Lopez, R. Pittner, Ming-Wei Wang, T. Rink (1993)
Evidence for release of free glucose from muscle during amylin‐induced glycogenolysis in ratsFEBS Letters, 334
A. Natali, D. Santoro, C. Palombo, M. Cerri, S. Ghione, E. Ferrannini (1991)
Impaired Insulin Action on Skeletal Muscle Metabolism in Essential HypertensionHypertension, 17
J. Molina, G. Cooper, B. Leighton, J. Olefsky (1990)
Induction of Insulin Resistance In Vivo by Amylin and Calcitonin Gene–Related PeptideDiabetes, 39
Garth Cooper, Brendan Leighton, George Dimitriadis, M. Parry-billings, J. Kowalchuk, Kevin Howland, Jonathan Rothbard, Antony Willis, Kenneth Reid (1988)
Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America, 85 20
T. Ciaraldi, M. Goldberg, Rosanne Odom, Matthew Stolpe (1992)
In Vitro Effects of Amylin on Carbohydrate Metabolism in Liver CellsDiabetes, 41
A. Sharma, K. Ruland, K. Spies, A. Distler (1991)
Salt sensitivity in young normotensive subjects is associated with a hyperinsulinemic response to oral glucose.Journal of hypertension, 9 4
Mohammed Saad, W. Knowler, DavidJ. Pettitt, Robert Nelson, David Mott, Peter Bennett (1988)
The natural history of impaired glucose tolerance in the Pima Indians.The New England journal of medicine, 319 23
J. Hall, H. Mizelle, D. Hildebrandt, M. Brands (1990)
Abnormal pressure natriuresis. A cause or a consequence of hypertension?Hypertension, 15 6 Pt 1
A. Young, Ming-Wei Wang, G. Cooper (1991)
Amylin injection causes elevated plasma lactate and glucose in the ratFEBS Letters, 291
H. Ohsawa, A. Kanatsuka, T. Yamaguchi, H. Makino, S. Yoshida (1989)
Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets.Biochemical and biophysical research communications, 160 2
S. Yoshioka, Hiroshi Nishino, Tomoko Shiraki, Keiko Ikeda, Hiroyuki Koike, Akira Okuno, Mikiyo Wada, Toshihiko Fujiwara, H. Horikoshi (1993)
Antihypertensive effects of CS-045 treatment in obese Zucker rats.Metabolism: clinical and experimental, 42 1
J. Lupien, A. Young (1993)
No measurable effect of amylin on lipolysis in either white or brown isolated adipocytes from ratsDiabetes Nutrition & Metabolism, 6
K. Landin, Lilian Tengborn, Ulf Smith (1991)
Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factorsJournal of Internal Medicine, 229
G. Reaven, Helen Ho, B. Hoffman (1988)
Attenuation of Fructose‐Induced Hypertension in Rats by Exercise TrainingHypertension, 12
I. Saito, E. Takeshita, T. Saruta, S. Nagano, T. Sekihara (1986)
Urinary dopamine excretion in normotensive subjects with or without family history of hypertension.Journal of hypertension, 4 1
D. Bradley, R. Poulin, R. Bergman (1993)
Dynamics of Hepatic and Peripheral Insulin Effects Suggest Common Rate-Limiting Step In VivoDiabetes, 42
Lee-Ming Chuang, Huey‐Peir Wu, T. Jou, T. Tai, B. Lin (1992)
Inhibitory Effect of Islet Amyloid Polypeptide of Glucose‐Induced Proinsulin Biosynthesis in Rat Insulinoma CellsPancreas, 7
C. Ryan, Theresa Williams, T. Orchard, D. Finegold (1992)
Psychomotor Slowing Is Associated With Distal Symmetrical Polyneuropathy in Adults With Diabetes MellitusDiabetes, 41
A. Rocchini, Jane Key, D. Bondie, R. Chico, C. Moorehead, V. Katch, Monica Martin (1989)
The effect of weight loss on the sensitivity of blood pressure to sodium in obese adolescents.The New England journal of medicine, 321 9
C. Burchfiel, S. Shetterly, J. Baxter, R. Hamman (1992)
The roles of insulin, obesity, and fat distribution in the elevation of cardiovascular risk factors in impaired glucose tolerance. The San Luis Valley Diabetes Study.American journal of epidemiology, 136 9
R. Jarrett (1992)
In defence of insulin: a critique of syndrome XThe Lancet, 340
J. Koda, M. Fineman, T. Rink, G. Dailey, D. Muchmore, L. Linarelli (1992)
Amylin concentrations and glucose controlThe Lancet, 339
A. Swislocki (1990)
Insulin resistance and hypertension.The American journal of the medical sciences, 300 2
T. Pollare, H. Lithell, C. Berne (1990)
Insulin resistance is a characteristic feature of primary hypertension independent of obesity.Metabolism: clinical and experimental, 39 2
H. Yasuda, S. Suzuki, K. Yamashita, T. Kaneko, H. Oka (1976)
Inhibition of insulin release by synthetic rat C-peptide II in isolated rat islets.Endocrinologia japonica, 23 3
Sechi La, Sechi La, A. Melis, A. Melis, R. Tedde, R. Tedde (1992)
Insulin hypersecretion: a distinctive feature between essential and secondary hypertension.Metabolism: clinical and experimental, 41 11
G. Reaven, Helen Ho, Brian Hoffmann (1989)
Somatostatin Inhibition of Fructose‐Induced HypertensionHypertension, 14
J. Wood, J. Cash (1939)
OBESITY AND HYPERTENSION: CLINICAL AND EXPERIMENTAL OBSERVATIONS*Annals of Internal Medicine, 13
J. Hall (1991)
The renin-angiotensin system: renal actions and blood pressure regulation.Comprehensive therapy, 17 5
P. Ferrari, P. Weidmann, S. Shaw, Daniel Giachino, W. Riesen, Y. Allemann, G. Heynen (1991)
Altered insulin sensitivity, hyperinsulinemia, and dyslipidemia in individuals with a hypertensive parent.The American journal of medicine, 91 6
I. Hwang, H. Ho, B. Hoffman, G. Reaven (1987)
Fructose-induced insulin resistance and hypertension in rats.Hypertension, 10 5
R. DeFronzo, E. Ferrannini, D. Simonson (1989)
Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.Metabolism: clinical and experimental, 38 4
G. Reaven (1988)
Role of Insulin Resistance in Human DiseaseDiabetes, 37
H. Jamal, D. Bretherton‐Watt, K. Suda, M. Ghatei, S. Bloom (1990)
Islet amyloid polypeptide-like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin.The Journal of endocrinology, 126 3
T. Awata, T. Kuzuya, A. Matsuda, Y. Iwamoto, Y. Kanazawa, Machiko Okuyama, T. Juji (1990)
High Frequency of Aspartic Acid at Position 57 of HLA-DQ β-Chain in Japanese IDDM Patients and Nondiabetic SubjectsDiabetes, 39
S. O’Rahilly, R. Turner, D. Matthews (1988)
Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.The New England journal of medicine, 318 19
C. Lewis, A. Clark, S. Ashcroft, Garth Cooper, J. Morris (1988)
Calcitonin gene-related peptide and somatostatin inhibit insulin release from individual rat B cellsMolecular and Cellular Endocrinology, 57
M. Stridsberg, E. Wilander, K. Oberg, G. Lundqvist, B. Eriksson (1992)
Islet amyloid polypeptide-producing pancreatic islet cell tumor. A clinical and biochemical characterization.Scandinavian journal of gastroenterology, 27 5
J. Peuler, B. Johnson, S. Phare, J. Sowers (1993)
Sex-specific effects of an insulin secretagogue in stroke-prone hypertensive rats.Hypertension, 22 2
P. Wagoner, C. Chen, J. Worley, I. Dukes, G. Oxford (1993)
Amylin modulates beta-cell glucose sensing via effects on stimulus-secretion coupling.Proceedings of the National Academy of Sciences of the United States of America, 90 19
J. Hall (1993)
Hyperinsulinemia: a link between obesity and hypertension?Kidney international, 43 6
K. Beaumont, M. Kenney, A. Young, T. Rink (1993)
High affinity amylin binding sites in rat brain.Molecular pharmacology, 44 3
A. Young, P. Carlo, T. Rink, M. Wang (1992)
8–37hCGRP, an amylin receptor antagonist, enhances the insulin response and perturbs the glucose response to infused arginine in anesthetized ratsMolecular and Cellular Endocrinology, 84
R. DeFronzo, Riccardd Bonadonna, E. Ferrannini (1992)
Pathogenesis of NIDDM: A Balanced OverviewDiabetes Care, 15
Jaime Uribarri, Man Oh, Hugh Carroll (1990)
Hyperkalemia in diabetes mellitus.The Journal of diabetic complications, 4 1
T. Welborn, A. Breckenridge, A. Rubinstein, C. Dollery, T. Fraser (1966)
Serum-insulin in essential hypertension and in peripheral vascular disease.Lancet, 1 7451
M. Brands, H. Mizelle, C. Gaillard, D. Hildebrandt, J. Hall (1991)
The hemodynamic response to chronic hyperinsulinemia in conscious dogs.American journal of hypertension, 4 2 Pt 1
H. Huang, A. Young, J. Koda, O. Tulp, M. Johnson, G. Cooper (1992)
Hyperamylinemia, hyperinsulinemia, and insulin resistance in genetically obese LA/N-cp rats.Hypertension, 19 1 Suppl
L. Malatino, C. Fiore, R. Foti, F. Guzzardi, G. Tamburino (1987)
Acute effects of salmon calcitonin in man include stimulation of the renin-angiotensin-aldosterone system.Mineral and electrolyte metabolism, 13 5
A. Gill, T. Yen (1991)
Effects of ciglitazone on endogenous plasma islet amyloid polypeptide and insulin sensitivity in obese-diabetic viable yellow mice.Life sciences, 48 7
R. Page, K. Harnden, N. Walravens, C. Onslow, P. Sutton, J. Levy, D. Hockaday, R. Turner (1993)
'Healthy living' and sulphonylurea therapy have different effects on glucose tolerance and risk factors for vascular disease in subjects with impaired glucose tolerance.The Quarterly journal of medicine, 86 3
Charles Lucas, Juan Estigarribia, L. Darga, M. Reaven (1985)
Insulin and blood pressure in obesity.Hypertension, 7 5
T. Rink, K. Beaumont, J. Koda, A. Young (1993)
Structure and biology of amylin.Trends in pharmacological sciences, 14 4
D. Shen, S. Shieh, M. Fuh, D. Wu, Ydi Chen, G. Reaven, P. Chu (1988)
Resistance to insulin-stimulated-glucose uptake in patients with hypertension.The Journal of clinical endocrinology and metabolism, 66 3
A. Christlieb (1974)
Renin, Angiotensin, and Norepinephrine in Alloxan DiabetesDiabetes, 23
T. O'Brien, W. Young, P. Palumbo, P. O'brien, F. Service (1993)
Hypertension and dyslipidemia in patients with insulinoma.Mayo Clinic proceedings, 68 2
D. Wright, R. Hansen, C. Mondon, G. Reaven (1983)
Sucrose-induced insulin resistance in the rat: modulation by exercise and diet.The American journal of clinical nutrition, 38 6
A. Kashiwagi, D. Mott, C. Bogardus, S. Lillioja, G. Reaven, J. Foley (1985)
The effects of short-term overfeeding on adipocyte metabolism in Pima Indians.Metabolism: clinical and experimental, 34 4
A. Kurtz, R. Muff, W. Born, J. Lundberg, B. Millberg, M. Gnädinger, D. Uehlinger, P. Weidmann, T. Hökfelt, J. Fischer (1988)
Calcitonin gene-related peptide is a stimulator of renin secretion.The Journal of clinical investigation, 82 2
M. Stern, P. Morales, S. Haffner, Rodolfo Valdez (1992)
Hyperdynamic circulation and the insulin resistance syndrome ("syndrome X").Hypertension, 20 6
A 37 amino‐acid peptide, amylin, is secreted from the pancreatic β‐cell in response to stimuli similar to those causing insulin secretion. Plasma amylin levels are generally elevated under circumstances where insulin is elevated, including in insulin resistance and in essential (obesity‐related) hypertension. Several of amylin's actions may contribute to key features of insulin resistance and the insulin resistance syndrome (Syndrome‐X). Actions on muscle glycogen metabolism, Cori cycle activity, and endogenous glucose production may contribute to glucose intolerance while amylin's effects to suppress β‐cell secretion could account for the secretory defect observed in early glucose intolerance. Amylin also potently increases plasma renin activity, and could contribute to the hypertension that is associated with obesity and insulin resistance.
Drug Development Research – Wiley
Published: Jun 1, 1994
Keywords: insulin resistance; obesity; muscle; liver; lactate; renin; hypertension
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.