Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. Vakhrushev, Michael Mormann, J. Peter-Katalinic (2006)
Identification of glycoconjugates in the urine of a patient with congenital disorder of glycosylation by high‐resolution mass spectrometryPROTEOMICS, 6
G. Heuvel (2010)
CD14 : a candidate biomarker for the prognosis of polycystic kidney disease.Kidney international, 78 6
Sun‐Hee Heo, Seung‐Jin Lee, H. Ryoo, Jae-Yong Park, Je-Yoel Cho (2007)
Identification of putative serum glycoprotein biomarkers for human lung adenocarcinoma by multilectin affinity chromatography and LC‐MS/MSPROTEOMICS, 7
Lau Wai-Hoe, Leong Wing-Seng, Z. Ismail, Gam Lay-Harn (2009)
Proteomics and Detection of Uromodulin in First-time Renal Calculi Patients and Recurrent Renal Calculi PatientsApplied Biochemistry and Biotechnology, 159
Zhaoyu Qin, Yanjiang Qin, Shilian Liu (2009)
Alteration of DBP Levels in CSF of Patients with MS by Proteomics AnalysisCellular and Molecular Neurobiology, 29
Hirokazu Nakayama, H. Echizen, T. Gomi, Yuko Shibuya, Yoshitsugu Nakamura, K. Nakano, H. Arashi, T. Itai, S. Ohnishi, Masayo Tanaka, T. Orii (2009)
Urinary Lipocalin-Type Prostaglandin D Synthase: A Potential Marker for Early Gentamicin-Induced Renal Damage?Therapeutic Drug Monitoring, 31
N. Vasudev, S. Sim, D. Cairns, R. Ferguson, R. Craven, A. Stanley, J. Cartledge, D. Thompson, P. Selby, R. Banks (2009)
Pre-operative urinary cathepsin D is associated with survival in patients with renal cell carcinomaBritish Journal of Cancer, 101
R. Ramírez-Llanelis, E. Llop, R. Ventura, J. Segura, R. Gutiérrez-Gallego (2008)
Can glycans unveil the origin of glycoprotein hormones? - human chorionic gonadotrophin as an example -.Journal of mass spectrometry : JMS, 43 7
Arivusudar Marimuthu, Robert O’Meally, R. Chaerkady, Yashwanth Subbannayya, Vishalakshi Nanjappa, Praveen Kumar, Dhanashree Kelkar, S. Pinto, Rakesh Sharma, S. Renuse, S. Renuse, R. Goel, R. Christopher, B. Delanghe, R. Cole, H. Harsha, A. Pandey (2011)
A comprehensive map of the human urinary proteome.Journal of proteome research, 10 6
Siti Abdullah-Soheimi, B. Lim, O. Hashim, A. Shuib (2010)
Patients with ovarian carcinoma excrete different altered levels of urine CD59, kininogen-1 and fragments of inter-alpha-trypsin inhibitor heavy chain H4 and albuminProteome Science, 8
C. Chen, R. Chen, J. Preston (2009)
Age-related increase of prostaglandin D2 synthase concentration and glycation in ovine cerebrospinal fluidExperimental Gerontology, 44
Hiroyuki Yokota, M. Hiramoto, H. Okada, Y. Kanno, M. Yuri, Shuji Morita, M. Naitou, Atsushi Ichikawa, M. Katoh, Hiromichi Suzuki (2007)
Absence of increased alpha1-microglobulin in IgA nephropathy proteinuria.Molecular & cellular proteomics : MCP, 6 4
P. Devarajan, C. Krawczeski, Mai Nguyen, Thelma Kathman, Zhu Wang, C. Parikh (2010)
Proteomic identification of early biomarkers of acute kidney injury after cardiac surgery in children.American journal of kidney diseases : the official journal of the National Kidney Foundation, 56 4
Nishma Gupta, N. Shankernarayan, K. Dharmalingam (2010)
alpha1-acid glycoprotein as a putative biomarker for monitoring the development of the type II reactional stage of leprosy.Journal of medical microbiology, 59 Pt 4
Y. Goo, Yihsuan Tsai, Alvin Liu, D. Goodlett, Claire Yang (2010)
Urinary proteomics evaluation in interstitial cystitis/painful bladder syndrome: a pilot study.International braz j urol : official journal of the Brazilian Society of Urology, 36 4
T. Imre, T. Kremmer, K. Héberger, Eva Molnár-Szöllosi, K. Ludányi, G. Pocsfalvi, A. Malorni, L. Drahos, K. Vékey (2008)
Mass spectrometric and linear discriminant analysis of N-glycans of human serum alpha-1-acid glycoprotein in cancer patients and healthy individuals.Journal of proteomics, 71 2
P. Hörth, Christine Miller, T. Preckel, C. Wenz (2006)
Efficient Fractionation and Improved Protein Identification by Peptide OFFGEL Electrophoresis*SMolecular & Cellular Proteomics, 5
R. Rajpal, P. Dowling, J. Meiller, C. Clarke, W. Murphy, R. O'Connor, M. Kell, C. Mitsiades, P. Richardson, K. Anderson, M. Clynes, P. O’gorman (2011)
A novel panel of protein biomarkers for predicting response to thalidomide‐based therapy in newly diagnosed multiple myeloma patientsPROTEOMICS, 11
Hua Zhou, T. Pisitkun, A. Aponte, P. Yuen, J. Hoffert, H. Yasuda, Xuzhen Hu, L. Chawla, Rong‐Fong Shen, M. Knepper, R. Star (2006)
Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury.Kidney international, 70 10
R. Skipworth, G. Stewart, M. Bhana, J. Christie, C. Sturgeon, D. Guttridge, A. Cronshaw, K. Fearon, J. Ross (2010)
Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine.International journal of oncology, 36 4
Samta Jain, Anuradha Rajput, Y. Kumar, N. Uppuluri, A. Arvind, U. Tatu (2005)
Proteomic analysis of urinary protein markers for accurate prediction of diabetic kidney disorder.The Journal of the Association of Physicians of India, 53
A. Vilasi, P. Cutillas, A. Maher, S. Zirah, G. Capasso, A. Norden, E. Holmes, J. Nicholson, R. Unwin (2007)
Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome.American journal of physiology. Renal physiology, 293 2
J. Adachi, Chanchal Kumar, Yanling Zhang, J. Olsen, M. Mann (2006)
The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteinsGenome Biology, 7
Jisun Oh, Jae-Hoon Pyo, Eun-Hyun Jo, Sun-il Hwang, Sun-Chul Kang, Jaehak Jung, E. Park, Shin-Yoon Kim, Je-Yong Choi, Jinkyu Lim (2004)
Establishment of a near‐standard two‐dimensional human urine proteomic mapPROTEOMICS, 4
H. Komaba, M. Fukagawa (2009)
Fetuin-mineral complex: a new potential biomarker for vascular calcification?Kidney international, 75 9
Qing-Run Li, Ke-Xin Fan, Rongxia Li, J. Dai, Chaochao Wu, Shi-lin Zhao, Jia-Rui Wu, C. Shieh, R. Zeng (2010)
A comprehensive and non-prefractionation on the protein level approach for the human urinary proteome: touching phosphorylation in urine.Rapid communications in mass spectrometry : RCM, 24 6
Shumei Bai, Shilian Liu, Xu-xiao Guo, Zhaoyu Qin, B. Wang, Xiaohong Li, Yanjiang Qin, Yi-hsin Liu (2009)
Proteome analysis of biomarkers in the cerebrospinal fluid of neuromyelitis optica patientsMolecular Vision, 15
R. Saldova, M. Wormald, R. Dwek, P. Rudd (2009)
Glycosylation Changes on Serum Glycoproteins in Ovarian Cancer May Contribute to Disease PathogenesisDisease markers, 25
S. Goodison, C. Rosser, V. Urquidi (2009)
Urinary proteomic profiling for diagnostic bladder cancer biomarkersExpert Review of Proteomics, 6
Wai-Hoe Lau, W. Leong, Z. Ismail, L. Gam (2008)
Qualification and application of an ELISA for the determination of Tamm Horsfall Protein (THP) in human urine and its use for screening of Kidney Stone DiseaseInternational Journal of Biological Sciences, 4
Hiroyuki Yokota, M. Hiramoto, H. Okada, Y. Kanno, M. Yuri, Shuji Morita, M. Naitou, Atsushi Ichikawa, M. Katoh, Hiromichi Suzuki (2007)
Absence of Increased α1-Microglobulin in IgA Nephropathy Proteinuria*Molecular & Cellular Proteomics, 6
Tianfu Wu, Yuyang Fu, Deirdre Brekken, M. Yan, Xin Zhou, K. Vanarsa, Nima Deljavan, C. Ahn, C. Putterman, C. Mohan (2010)
Urine Proteome Scans Uncover Total Urinary Protease, Prostaglandin D Synthase, Serum Amyloid P, and Superoxide Dismutase as Potential Markers of Lupus NephritisThe Journal of Immunology, 184
Chen Shao, Yan Wang, Youhe Gao (2011)
Applications of urinary proteomics in biomarker discoveryScience China Life Sciences, 54
Jae Yi, J. Chang, W. Han, Jong Lee, E. Ko, D. Kim, Ji‐Yeon Bae, Jonghan Yu, Cheolju Lee, Myeong-Hee Yu, D. Noh (2008)
Autoantibody to Tumor Antigen, Alpha 2-HS Glycoprotein: A Novel Biomarker of Breast Cancer Screening and DiagnosisCancer Epidemiology Biomarkers & Prevention, 18
R. Pieper, C. Gatlin, A. McGrath, A. Makusky, Madhu Mondal, M. Seonarain, Erin Field, C. Schatz, M. Estock, N. Ahmed, N. Anderson, S. Steiner (2004)
Characterization of the human urinary proteome: A method for high‐resolution display of urinary proteins on two‐dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spotsPROTEOMICS, 4
L. Foster, Carmen Hoog, M. Mann (2003)
Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factorsProceedings of the National Academy of Sciences of the United States of America, 100
A. Kentsis, Flavio Monigatti, Kevin Dorff, F. Campagne, R. Bachur, H. Steen (2009)
Urine proteomics for profiling of human disease using high accuracy mass spectrometryPROTEOMICS – Clinical Applications, 3
Hong-lin Cheng, Hung-Jen Huang, Bing-Yuan Ou, N. Chow, Yen-Wen Chen, T. Tzai, Chin-Jen Wu, Shu-Hui Chen (2011)
Urinary CD14 as a potential biomarker for benign prostatic hyperplasia – discovery by combining MALDI‐TOF‐based biostatistics and ESI‐MS/MS‐based stable‐isotope labelingPROTEOMICS – Clinical Applications, 5
Yanling Zhang, Yong Zhang, J. Adachi, J. Olsen, R. Shi, G. Souza, E. Pasini, L. Foster, Boris Macek, A. Zougman, Chanchal Kumar, J. Wiśniewski, Jan Wang, M. Mann (2006)
MAPU: Max-Planck Unified database of organellar, cellular, tissue and body fluid proteomesNucleic Acids Research, 35
N. Piyaphanee, Q. Ma, O. Kremen, K. Czech, K. Greis, M. Mitsnefes, P. Devarajan, M. Bennett (2011)
Discovery and initial validation of α 1‐B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid‐resistant nephrotic syndromePROTEOMICS – Clinical Applications, 5
Patricia Gonzales, T. Pisitkun, J. Hoffert, D. Tchapyjnikov, R. Star, R. Kleta, N. Wang, M. Knepper (2009)
Large-scale proteomics and phosphoproteomics of urinary exosomes.Journal of the American Society of Nephrology : JASN, 20 2
R. Yoshikawa, J. Wada, K. Seiki, Takashi Matsuoka, S. Miyamoto, Kenji Takahashi, S. Ota, K. Taniai, K. Hida, M. Yamakado, K. Shikata, Y. Uehara, Y. Urade, H. Makino (2007)
Urinary PGDS levels are associated with vascular injury in type 2 diabetes patients.Diabetes research and clinical practice, 76 3
S. Szajda, J. Snarska, Anna Jankowska, W. Roszkowska-Jakimiec, Z. Puchalski, K. Zwierz (2008)
Cathepsin D and carcino-embryonic antigen in serum, urine and tissues of colon adenocarcinoma patients.Hepato-gastroenterology, 55 82-83
S. Riaz, S. Alam, S. Srai, V. Skinner, Aasma Riaz, M. Akhtar (2010)
Proteomic identification of human urinary biomarkers in diabetes mellitus type 2.Diabetes technology & therapeutics, 12 12
L. Vojtová, T. Zima, V. Tesar, Jana Míchalová, P. Přikryl, G. Dostálová, A. Linhart (2010)
Study of urinary proteomes in Anderson-Fabry diseaseRenal Failure, 32
Ying Gao, Ke Wu, Yi Xu, Hongmin Zhou, Wen-tao He, Weina Zhang, Lanjun Cai, Xing-guang Lin, Zemin Fang, Zhenlong Luo, Hui Guo, Zhonghua Chen (2009)
Characterization of acute renal allograft rejection by human serum proteomic analysisJournal of Huazhong University of Science and Technology [Medical Sciences], 29
Xiong-fei Jia, Cheng-jun Gan, K. Xiao, Weifeng He, Zhang Tao, C.‐I. Huang, Xiongfei Wu, G. Luo, Xiaojuan Wang, Jie Hu, Jianglin Tan, Xiao-rong Zhang, P. Larsen, Jun Wu (2009)
Detection of urinary biomarkers for early diagnosis of acute renal allograft rejection by proteomic analysisPROTEOMICS – Clinical Applications, 3
R. Saldova, L. Royle, C. Radcliffe, U. Hamid, R. Evans, J. Arnold, R. Banks, R. Hutson, D. Harvey, R. Antrobus, S. Petrescu, R. Dwek, P. Rudd (2007)
Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG.Glycobiology, 17 12
F. Aregger, C. Pilop, D. Uehlinger, R. Brunisholz, T. Carrel, F. Frey, B. Frey (2010)
Urinary proteomics before and after extracorporeal circulation in patients with and without acute kidney injury.The Journal of thoracic and cardiovascular surgery, 139 3
Ángel Soler-García, Douglas Johnson, Y. Hathout, P. Ray (2009)
Iron-related proteins: candidate urine biomarkers in childhood HIV-associated renal diseases.Clinical journal of the American Society of Nephrology : CJASN, 4 4
G. Coen, P. Paolis, P. Ballanti, A. Pierantozzi, S. Pisanò, D. Sardella, D. Mantella, L. Pellegrino, G. Silvestrini, M. Iappelli, S. Giulio (2011)
Peripheral artery calcifications evaluated by histology correlate to those detected by CT: relationships with fetuin-A and FGF-23.Journal of nephrology, 24 3
Shikha Taneja, S. Sen, V. Gupta, R. Aggarwal, S. Jameel (2009)
Plasma and urine biomarkers in acute viral hepatitis EProteome Science, 7
L. Quintana, J. Campistol, M. Alcolea, E. Bañon-maneus, Amandaé Sol-González, P. Cutillas (2009)
Application of Label-free Quantitative Peptidomics for the Identification of Urinary Biomarkers of Kidney Chronic Allograft Dysfunction*Molecular & Cellular Proteomics, 8
Yinghua Qiu, Tasneem Patwa, Li Xu, K. Shedden, David Misek, M. Tuck, G. Jin, M. Ruffin, D. Turgeon, Sapna Synal, R. Bresalier, N. Marcon, D. Brenner, D. Lubman (2008)
Plasma glycoprotein profiling for colorectal cancer biomarker identification by lectin glycoarray and lectin blot.Journal of proteome research, 7 4
T. Pisitkun, Rong‐Fong Shen, M. Knepper (2004)
Identification and proteomic profiling of exosomes in human urine.Proceedings of the National Academy of Sciences of the United States of America, 101 36
Nagarjuna Nagaraj, M. Mann (2011)
Quantitative analysis of the intra- and inter-individual variability of the normal urinary proteome.Journal of proteome research, 10 2
S. Decramer, Anne Peredo, B. Breuil, H. Mischak, B. Monsarrat, J. Bascands, J. Schanstra (2008)
Urine in Clinical Proteomics*Molecular & Cellular Proteomics, 7
H. Bolt, M. Lammert, S. Selinski, T. Brüning (2004)
Urinary α1-microglobulin excretion as biomarker of renal toxicity in trichloroethylene-exposed personsInternational Archives of Occupational and Environmental Health, 77
V. Thongboonkerd, S. Chutipongtanate, R. Kanlaya (2006)
Systematic evaluation of sample preparation methods for gel-based human urinary proteomics: quantity, quality, and variability.Journal of proteome research, 5 1
Jie Wu, Na Wang, Jie Wang, Yuansheng Xie, Yan Li, T. Liang, Jianzhong Wang, Z. Yin, Kun He, Xiangmei Chen (2010)
Identification of a uromodulin fragment for diagnosis of IgA nephropathy.Rapid communications in mass spectrometry : RCM, 24 14
A. Kistler, H. Mischak, Diane Poster, M. Dakna, R. Wüthrich, A. Serra (2009)
Identification of a unique urinary biomarker profile in patients with autosomal dominant polycystic kidney disease.Kidney international, 76 1
Wei Sun, Yong Chen, Fuxin Li, Ling Zhang, Ruifeng Yang, Zhi Zhang, Dexian Zheng, Youhe Gao (2009)
Dynamic urinary proteomic analysis reveals stable proteins to be potential biomarkersPROTEOMICS – Clinical Applications, 3
Jung-Mo Ahn, Byung‐Gyu Kim, M. Yu, In-kyu Lee, Je-Yoel Cho (2010)
Identification of diabetic nephropathy‐selective proteins in human plasma by multi‐lectin affinity chromatography and LC‐MS/MSPROTEOMICS – Clinical Applications, 4
P. Devarajan (2007)
Proteomics for biomarker discovery in acute kidney injury.Seminars in nephrology, 27 6
X. Ling, T. Sigdel, K. Lau, L. Ying, Irwin Lau, J. Schilling, M. Sarwal (2010)
Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection.Journal of the American Society of Nephrology : JASN, 21 4
Just as biomarkers specific for diseases, biomarkers indicative of healthy conditions are valuable for the early diagnosis, monitoring, and prognosis of diseases. Our study focused on discovering via proteomics a stable panel of urinary proteins in the human healthy population. Urine samples were collected three times during 4 months from 100 male and 100 female healthy donors and analyzed through four different fractionation techniques (i.e. in‐gel, 2D‐LC, OFFGEL, and mRP) coupled with HPLC‐Chip‐MS/MS. Thus, 1641 urinary proteins were identified with a high confidence, among which 70 exhibiting an intergender/day variation <0.25 were selected and matched with the previously published five largest urinary proteomes to get 56 candidate proteins. Next, a panel comprising 18 intact urinary proteins was constructed by comparing the urinary proteomes via SDS‐PAGE and 2DE. Finally, such 18 urinary proteins were validated via enzyme‐linked immunosorbent assay in eight healthy individuals. Most of these proteins had been related to multiple rather than to single diseases. Therefore, we surmise that this protein set could be used as a biomarker to assess the human health status. Further determinations of the normal fluctuations of the single urinary proteins in this series using samples from large numbers of healthy individuals are required prior to any application in clinical settings.
Proteomics – Wiley
Published: Apr 1, 2012
Keywords: ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.