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A cost-benefit analysis of prenatal diagnosis by amniocentesis in Denmark

A cost-benefit analysis of prenatal diagnosis by amniocentesis in Denmark A cost-benefit analysis of amniocentesis has been performed using both the excess-cost- and the replacement methods and several replacement and discount rates. In Denmark, amniocentesis is offered free of charge to various groups of pregnant women at risk for genetic disorders of the foetus. Most important is age ≥ 35 years. The analysis is based on incidence and survival rates for Down syndrome (trisomy 21), Patau's syndrome (trisomy 13) and Edwards' syndrome (trisomy 18), and on incidence and survival rates of children with neural tube defects. If amniocentesis were offered to all pregnant women independent of age, with a supposed participation rate of 75% and if only tangible costs and benefits were included, the analysis shows a benefitxost ratio greater than 1.0 using discount rates of 4% and 7% (both for the excess-cost- and replacement method); a benefitxost ratio less than 1.0 is found using 10%. The ratio is approximately 1.0, if pregnant women aged 15–19 and 20–24 years are excluded, using the discount rate 10%. Calculations for other participation rates have also been performed. If intangible costs and benefit are included, the results are uncertain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Genetics Wiley

A cost-benefit analysis of prenatal diagnosis by amniocentesis in Denmark

G oldstein , H enri; P hilip , J ohn
Clinical Genetics , Volume 37 (4) – Apr 1, 1990
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References (37)

Publisher
Wiley
Copyright
1990 Blackwell Munksgaard
ISSN
0009-9163
eISSN
1399-0004
DOI
10.1111/j.1399-0004.1990.tb04187.x
Publisher site
See Article on Publisher Site

Abstract

A cost-benefit analysis of amniocentesis has been performed using both the excess-cost- and the replacement methods and several replacement and discount rates. In Denmark, amniocentesis is offered free of charge to various groups of pregnant women at risk for genetic disorders of the foetus. Most important is age ≥ 35 years. The analysis is based on incidence and survival rates for Down syndrome (trisomy 21), Patau's syndrome (trisomy 13) and Edwards' syndrome (trisomy 18), and on incidence and survival rates of children with neural tube defects. If amniocentesis were offered to all pregnant women independent of age, with a supposed participation rate of 75% and if only tangible costs and benefits were included, the analysis shows a benefitxost ratio greater than 1.0 using discount rates of 4% and 7% (both for the excess-cost- and replacement method); a benefitxost ratio less than 1.0 is found using 10%. The ratio is approximately 1.0, if pregnant women aged 15–19 and 20–24 years are excluded, using the discount rate 10%. Calculations for other participation rates have also been performed. If intangible costs and benefit are included, the results are uncertain.

Journal

Clinical Genetics – Wiley

Published: Apr 1, 1990

Keywords: cost-benefit analysis; Down syndrome; neural tube defects; prenatal diagnostic

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