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I Can See Clearly Now... - The Scientist - Magazine of the Life Sciences

I Can See Clearly Now... - The Scientist - Magazine of the Life Sciences Image: Courtesy of Atto Bioscience SHARPER IMAGE: A section of mouse intestine imaged with both confocal and non-confocal microscopy Confocal imaging systems offer a number of improvements over conventional wide-field fluorescent microscopes, including greater spatial resolution and enhanced image quality. Most commercial confocal systems employ laser scanners, but these systems are generally expensive to purchase and maintain. And, because a given laser source can be tuned to emit at only a limited number of wavelengths, multiple lasers are required for investigators needing a modicum of flexibility with regard to fluorophore choice. As an alternative to laser-based imaging, Atto Bioscience of Rockville, Md., offers its CARV® technology, which enables full-spectrum, high-resolution confocal imaging in real time. The company currently offers this technology in two different formats: CARV modules, which scientists can use to add confocal imaging capabilities to inverted or upright epifluorescent microscopes purchased from a variety of manufacturers; and the Pathway HT™ platform for high-throughput applications. According to the company, CARV modules are easy to install, and once in place, users can switch back and forth between confocal and wide-field modes by flipping a single lever. The high-end Pathway HT platform, designed for drug-discovery applications, combines CARV-based confocal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Scientist The Scientist

I Can See Clearly Now... - The Scientist - Magazine of the Life Sciences

The Scientist , Volume 16 (21): 44 – Oct 28, 2002

I Can See Clearly Now... - The Scientist - Magazine of the Life Sciences

The Scientist , Volume 16 (21): 44 – Oct 28, 2002

Abstract

Image: Courtesy of Atto Bioscience SHARPER IMAGE: A section of mouse intestine imaged with both confocal and non-confocal microscopy Confocal imaging systems offer a number of improvements over conventional wide-field fluorescent microscopes, including greater spatial resolution and enhanced image quality. Most commercial confocal systems employ laser scanners, but these systems are generally expensive to purchase and maintain. And, because a given laser source can be tuned to emit at only a limited number of wavelengths, multiple lasers are required for investigators needing a modicum of flexibility with regard to fluorophore choice. As an alternative to laser-based imaging, Atto Bioscience of Rockville, Md., offers its CARV® technology, which enables full-spectrum, high-resolution confocal imaging in real time. The company currently offers this technology in two different formats: CARV modules, which scientists can use to add confocal imaging capabilities to inverted or upright epifluorescent microscopes purchased from a variety of manufacturers; and the Pathway HT™ platform for high-throughput applications. According to the company, CARV modules are easy to install, and once in place, users can switch back and forth between confocal and wide-field modes by flipping a single lever. The high-end Pathway HT platform, designed for drug-discovery applications, combines CARV-based confocal

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The Scientist
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© 1986-2010 The Scientist
ISSN
1759-796X
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Abstract

Image: Courtesy of Atto Bioscience SHARPER IMAGE: A section of mouse intestine imaged with both confocal and non-confocal microscopy Confocal imaging systems offer a number of improvements over conventional wide-field fluorescent microscopes, including greater spatial resolution and enhanced image quality. Most commercial confocal systems employ laser scanners, but these systems are generally expensive to purchase and maintain. And, because a given laser source can be tuned to emit at only a limited number of wavelengths, multiple lasers are required for investigators needing a modicum of flexibility with regard to fluorophore choice. As an alternative to laser-based imaging, Atto Bioscience of Rockville, Md., offers its CARV® technology, which enables full-spectrum, high-resolution confocal imaging in real time. The company currently offers this technology in two different formats: CARV modules, which scientists can use to add confocal imaging capabilities to inverted or upright epifluorescent microscopes purchased from a variety of manufacturers; and the Pathway HT™ platform for high-throughput applications. According to the company, CARV modules are easy to install, and once in place, users can switch back and forth between confocal and wide-field modes by flipping a single lever. The high-end Pathway HT platform, designed for drug-discovery applications, combines CARV-based confocal

Journal

The ScientistThe Scientist

Published: Oct 28, 2002

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