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Journals Advances in Physiology Education Volume 35 Issue 4

Abstract A challenging topic in undergraduate physiology courses is the complex interaction between the vertebrate endocrine system and the immune system. There are relatively few established and accessible laboratory exercises available to instructors to help their students gain a working understanding of these interactions. The present laboratory module was developed to show students how glucocorticoid receptor activity can be pharmacologically modulated in Xenopus laevis tadpoles and the resulting effects on thymus gland size visualized and quantified in vivo. After treating young tadpoles with a cortisol receptor agonist (dexamethasone) for 1 wk, students can easily visualize the suppressive effects of glucocorticoids on the intact thymus gland, which shrinks dramatically in size in response to this steroid hormone analog. However, the suppressive effect of dexamethasone is nullified in the presence of the glucocorticoid receptor antagonist RU-486, which powerfully illustrates the specific effects of glucocorticoid receptor inhibition on the immune system. Image analysis and statistics software are used to quantify the effects of glucocorticoid modulation on thymus size. Xenopus thymus endocrinology Copyright © 2011 The American Physiological Society « Previous | Next Article » Table of Contents This Article doi: 10.​1152/​advan.​00001.​2011 Adv Physiol Educ December 2011 vol. 35 no. 4 445-453 » Abstract Free Full Text Free Full Text (PDF) Free Classifications Teaching in the Laboratory Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in this journal Similar articles in Web of Science Download to citation manager Responses Submit a response No responses published Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Schreiber, A. M. PubMed Articles by Schreiber, A. M. Related Content Load related web page information Current Issue December 2011, 35 (4) Alert me to new issues of Adv Physiol Educ About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2011 the American Physiological Society Print ISSN: 1043-4046 Online ISSN: 1522-1229 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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Visualizing and quantifying the suppressive effects of glucocorticoids on the tadpole immune system in vivo

Schreiber, Alexander M.
Advances in Physiology Education , Volume 35 (4): 445
The American Physiological Society – Dec 1, 2011

More Info
  • Publisher American Physiological Society
  • Copyright Copyright © 2011 the American Physiological Society
  • ISSN 1043-4046
  • eISSN 1522-1229
  • D.O.I. 10.1152/advan.00001.2011
  • Publisher site Get PDF  

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