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Journals AJP - Endocrinology and Metabolism Volume 302 Issue 4

Abstract Whereas ghrelin is produced primarily in the stomach, a small amount of it is produced in pancreatic islets. Although exogenous administration of ghrelin suppresses insulin secretion in vitro or in vivo, the role of intraislet ghrelin in the regulation of insulin secretion in vivo remains unclear. To understand the physiological role of intraislet ghrelin in insulin secretion and glucose metabolism, we developed a transgenic (Tg) mouse model, rat insulin II promoter ghrelin-internal ribosomal entry site-ghrelin O -acyl transferase (RIP-GG) Tg mice, in which mouse ghrelin cDNA and ghrelin O -acyltransferase are overexpressed under the control of the rat insulin II promoter. Although pancreatic desacyl ghrelin levels were elevated in RIP-GG Tg mice, pancreatic ghrelin levels were not altered in animals on a standard diet. However, when Tg mice were fed a medium-chain triglyceride-rich diet (MCTD), pancreatic ghrelin levels were elevated to ∼16 times that seen in control animals. It seems likely that the gastric ghrelin cells possess specific machinery to provide the octanoyl acid necessary for ghrelin acylation but that this machinery is absent from pancreatic β-cells. Despite the overexpression of ghrelin, plasma ghrelin levels in the portal veins of RIP-GG Tg mice were unchanged from control levels. Glucose tolerance, insulin secretion, and islet architecture in RIP-GG Tg mice were not significantly different even when the mice were fed a MCTD. These results indicate that intraislet ghrelin does not play a major role in the regulation of insulin secretion in vivo. pancreas ghrelin d -acyltransferase Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print November 2011 , doi: 10.​1152/​ajpendo.​00341.​2011 AJP - Endo February 2012 vol. 302 no. 4 E403-E408 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpendo.00341.2011v1 302/4/E403 most recent Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Bando, M. Articles by Akamizu, T. PubMed PubMed citation Articles by Bando, M. Articles by Akamizu, T. Related Content Load related web page information Current Issue February 2012, 302 (4) Alert me to new issues of AJP - Endo About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0193-1849 Online ISSN: 1522-1555 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo

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  • Publisher American Physiological Society
  • Copyright Copyright © 2012 the American Physiological Society
  • ISSN 0193-1849
  • eISSN 1522-1555
  • D.O.I. 10.1152/ajpendo.00341.2011
  • Publisher site Get PDF  

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