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Journals AJP - Regulatory, Integrative and Comparative... Volume 302 Issue 2

Abstract Despite significant technological and pharmacological advancements, insulin replacement therapy fails to adequately replicate β-cell function, and so glucose control in type 1 diabetes mellitus (T1D) is frequently erratic, leading to periods of hypoglycemia. Moreover, the counterregulatory response (CRR) to falling blood glucose is impaired in diabetes, leading to an increased risk of severe hypoglycemia. It is now clear that the brain plays a significant role in the development of defective glucose counterregulation and impaired hypoglycemia awareness in diabetes. In this review, the basic intracellular glucose-sensing mechanisms are discussed, as well as the neural networks that respond to and coordinate the body's response to a hypoglycemic challenge. Subsequently, we discuss how the body responds to repeated hypoglycemia and how these adaptations may explain, at least in part, the development of impaired glucose counterregulation in diabetes. hypoglycemia hypothalamus hypoglycemia unawareness epinephrine glucagon Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print November 2011 , doi: 10.​1152/​ajpregu.​00531.​2011 AJP - Regu Physiol January 2012 vol. 302 no. 2 R215-R223 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: ajpregu.00531.2011v1 302/2/R215 most recent Classifications Review Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Beall, C. Articles by McCrimmon, R. J. PubMed PubMed citation Articles by Beall, C. Articles by McCrimmon, R. J. Related Content Load related web page information Current Issue January 2012, 302 (2) Alert me to new issues of AJP - Regu Physiol About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0363-6119 Online ISSN: 1522-1490 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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The physiology and pathophysiology of the neural control of the counterregulatory response

Beall, Craig; Ashford, Michael L.; McCrimmon, Rory J.
AJP - Regulatory, Integrative and Comparative Physiology , Volume 302 (2): R215
The American Physiological Society – Jan 1, 2012

More Info
  • Publisher American Physiological Society
  • Copyright Copyright © 2012 the American Physiological Society
  • ISSN 0363-6119
  • eISSN 1522-1490
  • D.O.I. 10.1152/ajpregu.00531.2011
  • Publisher site Get PDF  

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