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The inhibitory effect of Gβγ and Gβ isoform specificity on ENaC activity

The inhibitory effect of Gβγ and Gβ isoform specificity on ENaC activity REFERENCES 1. ↵ Ausiello DA , Stow JL , Cantiello HF , De Almeida JB , Benos DJ . Purified epithelial Na + channel complex contains the pertussis toxin-sensitive G alpha i-3 protein . J Biol Chem 267 : 4759 – 4765 , 1992 . OpenUrl Abstract / FREE Full Text 2. ↵ Ausiello DA , Stow JL , Patenaude CR , Cantiello HF . Guanine nucleotide binding proteins regulate epithelial Na + channels . Adv Exp Med Biol 290 : 333 – 343 , 1991 . OpenUrl CrossRef Medline 3. ↵ Becchetti A , Kemendy AE , Stockand JD , Sariban-Sohraby S , Eaton DC . Methylation increases the open probability of the epithelial sodium channel in A6 epithelia . J Biol Chem 275 : 16550 – 16559 , 2000 . OpenUrl Abstract / FREE Full Text 4. ↵ Bleasdale JE , Thakur NR , Gremban RS , Bundy GL , Fitzpatrick FA , Smith RJ , Bunting S . Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils . J Pharmacol Exp Ther 255 : 756 – 768 , 1990 . OpenUrl Abstract / FREE Full Text 5. ↵ Booth RE , Stockand JD . Targeted degradation of ENaC in response to PKC activation of the ERK1/2 cascade . Am J Physiol Renal Physiol 284 : F938 – F947 , 2003 . OpenUrl Abstract / FREE Full Text 6. ↵ Booth RE , Tong Q , Medina J , Snyder PM , Patel P , Stockand JD . A region directly following the second transmembrane domain in gamma ENaC is required for normal channel gating . J Biol Chem 278 : 41367 – 41379 , 2003 . OpenUrl Abstract / FREE Full Text 7. ↵ Brock C , Schaefer M , Reusch HP , Czupalla C , Michalke M , Spicher K , Schultz G , Nurnberg B . Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma . J Cell Biol 160 : 89 – 99 , 2003 . OpenUrl Abstract / FREE Full Text 8. ↵ Bugaj V , Pochynyuk O , Stockand JD . Activation of the epithelial Na + channel in the collecting duct by vasopressin contributes to water reabsorption . Am J Physiol Renal Physiol 297 : F1411 – F1418 , 2009 . OpenUrl Abstract / FREE Full Text 9. ↵ Cantiello HF , Patenaude CR , Ausiello DA . G protein subunit, α i-3, activates a pertussis toxin-sensitive Na+ channel from the epithelial cell line, A6 . J Biol Chem 264 : 20867 – 20870 , 1989 . OpenUrl Abstract / FREE Full Text 10. ↵ Cantiello HF , Patenaude CR , Ausiello DA . G-protein activation of an epithelial sodium channel is mediated via phospholipid metabolites . Kidney Int 37 : 213 , 1990 . OpenUrl 11. ↵ Duncia JV , Santella JB III . , Higley CA , Pitts WJ , Wityak J , Frietze WE , Rankin FW , Sun JH , Earl RA , Tabaka AC , Teleha CA , Blom KF , Favata MF , Manos EJ , Daulerio AJ , Stradley DA , Horiuchi K , Copeland RA , Scherle PA , Trzaskos JM , Magolda RL , Trainor GL , Wexler RR , Hobbs FW , Olson RE . MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products . Bioorg Med Chem Lett 8 : 2839 – 2844 , 1998 . OpenUrl CrossRef Medline 12. ↵ Dupre DJ , Robitaille M , Rebois RV , Hebert TE . The role of G beta gamma subunits in the organization, assembly, and function of GPCR signaling complexes . Annu Rev Pharmacol Toxicol 49 : 31 – 56 , 2009 . OpenUrl CrossRef Medline Web of Science 13. ↵ Ecelbarger CA , Kim GH , Wade JB , Knepper MA . Regulation of the abundance of renal sodium transporters and channels by vasopressin . Exp Neurol 171 : 227 – 234 , 2001 . OpenUrl CrossRef Medline Web of Science 14. ↵ Ercolani L , Stow JL , Boyle JF , Holtzman EJ , Lin H , Grove JR , Ausiello DA . Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells . Proc Natl Acad Sci USA 87 : 4635 – 4639 , 1990 . OpenUrl Abstract / FREE Full Text 15. ↵ Faure M , Voynoyasenetskaya TA , Bourne HR . cAMP and beta-gamma-subunits of heterotrimeric G-proteins stimulate the mitogen-activated protein-kinase pathway in cos-7 cells . J Biol Chem 269 : 7851 – 7854 , 1994 . OpenUrl Abstract / FREE Full Text 16. ↵ Gallego MS , Ling BN . Regulation of amiloride-sensitive Na + channels by endothelin-1 in distal nephron cells . Am J Physiol Renal Fluid Electrolyte Physiol 271 : F451 – F460 , 1996 . OpenUrl Abstract / FREE Full Text 17. ↵ Garty H , Palmer LG . Epithelial sodium channels: function, structure, and regulation . Physiol Rev 77 : 359 – 396 , 1997 . OpenUrl Abstract / FREE Full Text 18. ↵ Goldsmith ZG , Dhanasekaran DN . G protein regulation of MAPK networks . Oncogene 26 : 3122 – 3142 , 2007 . OpenUrl CrossRef Medline Web of Science 19. ↵ Grossmann C , Freudinger R , Mildenberger S , Krug AW , Gekle M . Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na + reabsorption . 286 : F1226 – F1231 , 2004 . 20. ↵ Gutkind JS . The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades . J Biol Chem 273 : 1839 – 1842 , 1998 . OpenUrl FREE Full Text 21. ↵ Harden TK , Sondek J . Regulation of phospholipase C isozymes by Ras superfamily GTPases . In: Annual Review of Pharmacology and Toxicology . Palo Alto, CA : Annual Reviews , 2006 , p. 355 – 379 . 22. ↵ Hawes BE , Vanbiesen T , Koch WJ , Luttrell LM , Lefkowitz RJ . Distinct pathways of G i -mediated and G q -mediated mitogen-activated protein-kinase activation . J Biol Chem 270 : 17148 – 17153 , 1995 . OpenUrl Abstract / FREE Full Text 23. ↵ Helms MN , Chen XJ , Ramosevac S , Eaton DC , Jain L . Dopamine regulation of amiloride-sensitive sodium channels in lung cells . Am J Physiol Lung Cell Mol Physiol 290 : L710 – L722 , 2006 . OpenUrl Abstract / FREE Full Text 24. ↵ Hepler JR , Gilman AG . G proteins . Trends Biochem Sci 17 : 383 – 387 , 1992 . OpenUrl CrossRef Medline Web of Science 25. ↵ Hers I , Tavare JM , Denton RM . The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity . FEBS Lett 460 : 433 – 436 , 1999 . OpenUrl CrossRef Medline Web of Science 26. ↵ Hou YM , Chang V , Capper AB , Taussig R , Gautam N . G protein beta subunit types differentially interact with a muscarinic receptor but not adenylyl cyclase type II or phospholipase C-beta 2/3 . J Biol Chem 276 : 19982 – 19988 , 2001 . 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Regulation of alveolar epithelial Na + channels by ERK1/2 in chlorine-breathing mice . Am J Respir Cell Mol Biol 46 : 342 – 354 , 2012 . OpenUrl CrossRef Medline Web of Science 35. ↵ Ling BN , Eaton DC . Effects of luminal Na + on single Na + channels in A6 cells, a regulatory role for protein kinase C . Am J Physiol Renal Fluid Electrolyte Physiol 256 : F1094 – F1103 , 1989 . OpenUrl Abstract / FREE Full Text 36. ↵ Ling BN , Kokko KE , Eaton DC . Prostaglandin E2 activates clusters of apical Cl − channels in principal cells via a cyclic adenosine monophosphate-dependent pathway . J Clin Invest 93 : 829 – 837 , 1994 . OpenUrl Medline Web of Science 37. ↵ Liu L , Duke BJ , Malik B , Yue Q , Eaton DC . Biphasic regulation of ENaC by TGF-α and EGF in renal epithelial cells . Am J Physiol Renal Physiol 296 : F1417 – F1427 , 2009 . OpenUrl Abstract / FREE Full Text 38. ↵ Lu R , Alioua A , Kumar Y , Kundu P , Eghbali M , Weisstaub NV , Gingrich JA , Stefani E , Toro L . c-Src tyrosine kinase, a critical component for 5-HT2A receptor-mediated contraction in rat aorta . J Physiol 586 : 3855 – 3869 , 2008 . OpenUrl Abstract / FREE Full Text 39. ↵ Luttrell DK , Luttrell LM . Not so strange bedfellows: G-protein-coupled receptors and Src family kinases . Oncogene 23 : 7969 – 7978 , 2004 . OpenUrl CrossRef Medline Web of Science 40. ↵ Luttrell LM . ‘Location, location, location’: activation and targeting of MAP kinases by G protein-coupled receptors . J Mol Endocrinol 30 : 117 – 126 , 2003 . OpenUrl Abstract 41. ↵ Ma H , Ling BN . Luminal adenosine receptors regulate amiloride-sensitive Na + channels in A6 distal nephron cells . Am J Physiol Renal Fluid Electrolyte Physiol 270 : F798 – F805 , 1996 . OpenUrl Abstract / FREE Full Text 42. ↵ Ma HP , Bao HF , Liang YY , Kemp MJ , Malik B , Ling BN , Eaton DC . ATP inhibits ENaC via both PIP, and PKC . In: 36th Annual Meeting of the American Society of Nephrology in San Diego, CA . 14 : 81A – 82A , 2003 . OpenUrl 43. ↵ Ma HP , Li L , Zhou ZH , Eaton DC , Warnock DG . ATP masks stretch activation of epithelial sodium channels in A6 distal nephron cells . Am J Physiol Renal Physiol 282 : F501 – F505 , 2002 . OpenUrl Abstract / FREE Full Text 44. ↵ Ma HP , Saxena S , Warnock DG . Anionic phospholipids regulate native and expressed epithelial sodium channel (ENaC) . JBC 277 : 7641 – 7644 , 2002 . OpenUrl Abstract / FREE Full Text 45. ↵ Marunaka Y , Eaton DC . Effects of vasopressin and cAMP on single amiloride-blockable Na channels . Am J Physiol Cell Physiol 260 : C1071 – C1084 , 1991 . OpenUrl Abstract / FREE Full Text 46. ↵ McIntire WE . Structural determinants involved in the formation and activation of G protein beta gamma dimers . Neurosignals 17 : 82 – 99 , 2009 . 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OpenUrl Abstract / FREE Full Text 51. ↵ Pochynyuk O , Bugaj V , Rieg T , Insel PA , Mironova E , Vallon V , Stockand JD . Paracrine regulation of the epithelial Na + channel in the mammalian collecting duct by purinergic P2Y 2 receptor tone . J Biol Chem 283 : 36599 – 36607 , 2008 . OpenUrl Abstract / FREE Full Text 52. ↵ Pochynyuk O , Rieg T , Bugaj V , Schroth J , Fridman A , Boss GR , Insel PA , Stockand JD , Vallon V . Dietary Na + inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y 2 -receptor tone . FASEB J 24 : 2056 – 2065 . 53. ↵ Pochynyuk O , Tong QS , Medina J , Vandewalle A , Staruschenko A , Bugaj V , Stockand JD . Molecular determinants of PI(4,5)P-2 and PI(3,4,5)P-3 regulation of the epithelial Na + channel . J Gen Physiol 130 : 399 – 413 , 2007 . OpenUrl Abstract / FREE Full Text 54. ↵ Rokaw MD , Benos DJ , Palevsky PM , Cunningham SA , West ME , Johnson JP . Regulation of a sodium channel-associated G-protein by aldosterone . J Biol Chem 271 : 4491 – 4496 , 1996 . OpenUrl Abstract / FREE Full Text 55. ↵ Rokaw MD , West M , Johnson JP . Rapamycin inhibits protein kinase C activity and stimulates Na + transport in A6 cells . J Biol Chem 271 : 32468 – 32473 , 1996 . OpenUrl Abstract / FREE Full Text 56. ↵ Rozengurt E . Mitogenic signaling pathways induced by G protein-coupled receptors . J Cell Physiol 213 : 589 – 602 , 2007 . OpenUrl CrossRef Medline Web of Science 57. ↵ Schild L . The epithelial sodium channel: from molecule to disease . In: Reviews of Physiology, Biochemistry and Pharmacology . New York : Springer , 2004 , p. 93 – 107 . 58. ↵ Schwindinger WF , Robishaw JD . Heterotrimeric G-protein beta gamma-dimers in growth and differentiation . Oncogene 20 : 1653 – 1660 , 2001 . OpenUrl CrossRef Medline Web of Science 59. ↵ Shi HK , Asher C , Chigaev A , Yung Y , Reuveny E , Seger R , Garty H . Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation . J Biol Chem 277 : 13539 – 13547 , 2002 . OpenUrl Abstract / FREE Full Text 60. ↵ Taruno A , Niisato N , Marunaka Y . Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases . Am J Physiol Renal Physiol 293 : F128 – F138 , 2007 . OpenUrl Abstract / FREE Full Text 61. ↵ Tong QS , Stockand JD . Receptor tyrosine kinases mediate epithelial Na + channel inhibition by epidermal growth factor . Am J Physiol Renal Physiol 288 : F150 – F161 , 2005 . OpenUrl Abstract / FREE Full Text 62. ↵ Veizis IE , Cotton CU . Abnormal EGF-dependent regulation of sodium absorption in ARPKD collecting duct cells . Am J Physiol Renal Physiol 288 : F474 – F482 , 2005 . OpenUrl Abstract / FREE Full Text 63. ↵ Vlahos CJ , Matter WF , Hui KY , Brown RF . A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) . J Biol Chem 269 : 5241 – 5248 , 1994 . OpenUrl Abstract / FREE Full Text 64. ↵ Watson AJ , Katz A , Simon MI . A 5th member of the mammalian g-protein beta-subunit family—expression in brain and activation of the beta-2 isotype of phospholipase-C . JBC 269 : 22150 – 22156 , 1994 . OpenUrl Abstract / FREE Full Text 65. ↵ Weixel KM , Edinger RS , Kester L , Guerriero CJ , Wang HM , Fang L , Kleyman TR , Welling PA , Weisz OA , Johnson JP . Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells . J Biol Chem 282 : 36534 – 36542 , 2007 . OpenUrl Abstract / FREE Full Text 66. ↵ Yu L , Eaton DC , Helms MN . Effect of divalent heavy metals on epithelial Na + channels in A6 cells . Am J Physiol Renal Physiol 293 : F236 – F244 , 2007 . OpenUrl Abstract / FREE Full Text 67. ↵ Yue G , Eaton DC . Protein kinase C does not affect epithelial Na + channel activity in A6 cells with inside-out patch clamp study . FASEB J 12 : 1042 , 1998 . OpenUrl 68. ↵ Yue G , Edinger RS , Bao HF , Johnson JP , Eaton DC . The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells . Am J Physiol Cell Physiol 279 : C81 – C88 , 2000 . OpenUrl Abstract / FREE Full Text 69. ↵ Yue G , Malik B , Eaton DC . Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates epithelial sodium channel activity in A6 cells . J Biol Chem 277 : 11965 – 11969 , 2002 . OpenUrl Abstract / FREE Full Text 70. ↵ Zhang Y , Sanchez D , Gorelik J , Klenerman D , Lab M , Edwards C , Korchev Y . Basolateral P2X4-like receptors regulate the extracellular ATP-stimulated epithelial Na + channel activity in renal epithelia . Am J Physiol Renal Physiol 292 : F1734 – F1740 , 2007 . OpenUrl Abstract / FREE Full Text Previous Next Back to top About the Cover About the Cover Cover image Image 1: Xin Zhang, Zi-Lun Li, John R Woollard, Alfonso Eirin, Behzad Ebrahimi, John A Crane, Xiang- Yang Zhu, Aditya Pawar, James D Krier, Kyra L. Jordan, Hui Tang, Stephen C. Textor, Amir Lerman, and Lilach O. Lerman. Obesity-metabolic derangement preserves hemodynamics but promotes intrarenal adiposity and macrophage infiltration in swine renovascular disease . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00043.2013. Image 2: Yun-Hee Choi, Brian T. McNally, and Peter Igarashi. Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1β . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00582.2012. Image 3: Soundarapandian Vijayakumar, Hu Peng, and George J Schwartz. Galectin-3 mediates oligomerization of secreted hensin using its carbohydrate recognition domain . Am J Physiol Renal Physiol ; published ahead of print May 8, 2013, doi:10.1152/ajprenal.00498.2012. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords G protein βγ subunits ENaC phospholipase C protein kinase C single channels Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Renal Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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The inhibitory effect of Gβγ and Gβ isoform specificity on ENaC activity

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References (77)

Publisher
The American Physiological Society
Copyright
Copyright © 2013 the American Physiological Society
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0363-6127
eISSN
1522-1466
DOI
10.1152/ajprenal.00009.2013
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23863469
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Abstract

REFERENCES 1. ↵ Ausiello DA , Stow JL , Cantiello HF , De Almeida JB , Benos DJ . Purified epithelial Na + channel complex contains the pertussis toxin-sensitive G alpha i-3 protein . J Biol Chem 267 : 4759 – 4765 , 1992 . OpenUrl Abstract / FREE Full Text 2. ↵ Ausiello DA , Stow JL , Patenaude CR , Cantiello HF . Guanine nucleotide binding proteins regulate epithelial Na + channels . Adv Exp Med Biol 290 : 333 – 343 , 1991 . OpenUrl CrossRef Medline 3. ↵ Becchetti A , Kemendy AE , Stockand JD , Sariban-Sohraby S , Eaton DC . Methylation increases the open probability of the epithelial sodium channel in A6 epithelia . J Biol Chem 275 : 16550 – 16559 , 2000 . OpenUrl Abstract / FREE Full Text 4. ↵ Bleasdale JE , Thakur NR , Gremban RS , Bundy GL , Fitzpatrick FA , Smith RJ , Bunting S . Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils . J Pharmacol Exp Ther 255 : 756 – 768 , 1990 . OpenUrl Abstract / FREE Full Text 5. ↵ Booth RE , Stockand JD . Targeted degradation of ENaC in response to PKC activation of the ERK1/2 cascade . Am J Physiol Renal Physiol 284 : F938 – F947 , 2003 . OpenUrl Abstract / FREE Full Text 6. ↵ Booth RE , Tong Q , Medina J , Snyder PM , Patel P , Stockand JD . A region directly following the second transmembrane domain in gamma ENaC is required for normal channel gating . J Biol Chem 278 : 41367 – 41379 , 2003 . OpenUrl Abstract / FREE Full Text 7. ↵ Brock C , Schaefer M , Reusch HP , Czupalla C , Michalke M , Spicher K , Schultz G , Nurnberg B . Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma . J Cell Biol 160 : 89 – 99 , 2003 . OpenUrl Abstract / FREE Full Text 8. ↵ Bugaj V , Pochynyuk O , Stockand JD . Activation of the epithelial Na + channel in the collecting duct by vasopressin contributes to water reabsorption . Am J Physiol Renal Physiol 297 : F1411 – F1418 , 2009 . OpenUrl Abstract / FREE Full Text 9. ↵ Cantiello HF , Patenaude CR , Ausiello DA . G protein subunit, α i-3, activates a pertussis toxin-sensitive Na+ channel from the epithelial cell line, A6 . J Biol Chem 264 : 20867 – 20870 , 1989 . OpenUrl Abstract / FREE Full Text 10. ↵ Cantiello HF , Patenaude CR , Ausiello DA . G-protein activation of an epithelial sodium channel is mediated via phospholipid metabolites . Kidney Int 37 : 213 , 1990 . OpenUrl 11. ↵ Duncia JV , Santella JB III . , Higley CA , Pitts WJ , Wityak J , Frietze WE , Rankin FW , Sun JH , Earl RA , Tabaka AC , Teleha CA , Blom KF , Favata MF , Manos EJ , Daulerio AJ , Stradley DA , Horiuchi K , Copeland RA , Scherle PA , Trzaskos JM , Magolda RL , Trainor GL , Wexler RR , Hobbs FW , Olson RE . MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products . Bioorg Med Chem Lett 8 : 2839 – 2844 , 1998 . OpenUrl CrossRef Medline 12. ↵ Dupre DJ , Robitaille M , Rebois RV , Hebert TE . The role of G beta gamma subunits in the organization, assembly, and function of GPCR signaling complexes . Annu Rev Pharmacol Toxicol 49 : 31 – 56 , 2009 . OpenUrl CrossRef Medline Web of Science 13. ↵ Ecelbarger CA , Kim GH , Wade JB , Knepper MA . Regulation of the abundance of renal sodium transporters and channels by vasopressin . Exp Neurol 171 : 227 – 234 , 2001 . OpenUrl CrossRef Medline Web of Science 14. ↵ Ercolani L , Stow JL , Boyle JF , Holtzman EJ , Lin H , Grove JR , Ausiello DA . Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells . Proc Natl Acad Sci USA 87 : 4635 – 4639 , 1990 . OpenUrl Abstract / FREE Full Text 15. ↵ Faure M , Voynoyasenetskaya TA , Bourne HR . cAMP and beta-gamma-subunits of heterotrimeric G-proteins stimulate the mitogen-activated protein-kinase pathway in cos-7 cells . J Biol Chem 269 : 7851 – 7854 , 1994 . OpenUrl Abstract / FREE Full Text 16. ↵ Gallego MS , Ling BN . Regulation of amiloride-sensitive Na + channels by endothelin-1 in distal nephron cells . Am J Physiol Renal Fluid Electrolyte Physiol 271 : F451 – F460 , 1996 . OpenUrl Abstract / FREE Full Text 17. ↵ Garty H , Palmer LG . Epithelial sodium channels: function, structure, and regulation . Physiol Rev 77 : 359 – 396 , 1997 . OpenUrl Abstract / FREE Full Text 18. ↵ Goldsmith ZG , Dhanasekaran DN . G protein regulation of MAPK networks . Oncogene 26 : 3122 – 3142 , 2007 . OpenUrl CrossRef Medline Web of Science 19. ↵ Grossmann C , Freudinger R , Mildenberger S , Krug AW , Gekle M . Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na + reabsorption . 286 : F1226 – F1231 , 2004 . 20. ↵ Gutkind JS . The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades . J Biol Chem 273 : 1839 – 1842 , 1998 . OpenUrl FREE Full Text 21. ↵ Harden TK , Sondek J . Regulation of phospholipase C isozymes by Ras superfamily GTPases . In: Annual Review of Pharmacology and Toxicology . Palo Alto, CA : Annual Reviews , 2006 , p. 355 – 379 . 22. ↵ Hawes BE , Vanbiesen T , Koch WJ , Luttrell LM , Lefkowitz RJ . Distinct pathways of G i -mediated and G q -mediated mitogen-activated protein-kinase activation . J Biol Chem 270 : 17148 – 17153 , 1995 . OpenUrl Abstract / FREE Full Text 23. ↵ Helms MN , Chen XJ , Ramosevac S , Eaton DC , Jain L . Dopamine regulation of amiloride-sensitive sodium channels in lung cells . Am J Physiol Lung Cell Mol Physiol 290 : L710 – L722 , 2006 . OpenUrl Abstract / FREE Full Text 24. ↵ Hepler JR , Gilman AG . G proteins . Trends Biochem Sci 17 : 383 – 387 , 1992 . OpenUrl CrossRef Medline Web of Science 25. ↵ Hers I , Tavare JM , Denton RM . 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Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords G protein βγ subunits ENaC phospholipase C protein kinase C single channels Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Renal Physiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following The inhibitory effect of Gβγ and Gβ isoform specificity on ENaC activity Message Subject (Your Name) has sent you a message from Renal Physiology Message Body (Your Name) thought you would like to see the Renal Physiology web site. Your Personal Message Print Citation Tools The inhibitory effect of G βγ and G β isoform specificity on ENaC activity Ling Yu , Otor Al-Khalili , Billie Jeanne Duke , James D. Stockand , Douglas C. Eaton , Hui-Fang Bao American Journal of Physiology - Renal Physiology Nov 2013, 305 (9) F1365-F1373; DOI: 10.1152/ajprenal.00009.2013 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share The inhibitory effect of G βγ and G β isoform specificity on ENaC activity The inhibitory effect of G βγ and G β isoform specificity on ENaC activity Ling Yu , Otor Al-Khalili , Billie Jeanne Duke , James D. Stockand , Douglas C. Eaton , Hui-Fang Bao American Journal of Physiology - Renal Physiology Nov 2013, 305 (9) F1365-F1373; DOI: 10.1152/ajprenal.00009.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria LIM homeobox transcription factor 1B expression affects renal interstitial fibrosis and apoptosis in unilateral ureteral obstructed rats Show more Articles Related Articles No related articles found. 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AJP - Renal Physiology – The American Physiological Society

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