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1939 ON No. 4 19 THE EFFECT OCTOBER, OF TOXAEMIA ERIC The Biochemical HOLMES Laboratory, Cambridge The recent progress made in biochemistry, which has depended as well upon the elaboration of new technique, as upon the intensive use of classical methods of investigation, has of recent years made it possible to approach some of the problems of pathology from a new angle. Hitherto, except in the case of certain diseasesclearly recognized as essentially âmetabolic,â such as diabetes, pathological changes have, for the most part, been recognized and described in terms of morbid histology. In conditions in which histological methods can be employed, they have often proved of the utmost value in diagnosis; indeed modern clinical medicine rests upon the foundations of morbid anatomy and morbid histology. Yet anatomical and histological investigation reveals changes in form without necessarily indicating how far such changes may be accompanied by an alteration in function. It may be obvious that the major part of an organ has been destroyed, and replaced by fibrous tissue; and such a finding may be correlated with a clinical picture which is dominated by gross insuficiency in the function of that organ. But such a condition, when far
Physiological Reviews – The American Physiological Society
Published: Oct 1, 1939
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