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BARRYE., JOSEPHANNC.. Studies of origins of abnormal in Zucker . Am. J. Physiol. 245 (Endocrinol. Metab. 8): E87E93, 1983.-To explain previously described abnormalities of in the genetically Zucker rat, the kinetics of norepinephrine (NE) metabolism were examined. Lower stress-induced levels of plasma NE in the rat were shown to be due to decreased release of NE because uptake of [âH]NE tracer from plasma was 45% slower in the compared with the rat. NE levels were 15, 20, 34% lower in heart, pancreas, interscapular brown adipose tissue (IBAT), NE turnover rates (determined by two independent methods) were 39-48 43-69% lower in the pancreas IBAT of compared with . In vivo synthesis of [âH]NE from [âHldopamine by the enzyme dopamine phydroxylase was 60% lower in IBAT but was equal in hearts of compared with . These results suggest an organspecific decrease of NE synthesis in the Zucker rat, possibly due to decreased dopamine ,&hydroxylase activity in IBAT. obesity; catecholamine metabolism; dopamine norepinephrine turnover; brown adipose tissue ,&hydroxylase; THE GENETICALLY ZUCKER RAT has been used extensively as a model for human obesity because the two types of obesity share a number of similar physiological metabolic abnormalities (2, 3). Two important abnormalities
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Jul 1, 1983
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