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Sodium balance after adrenal enucleation

Sodium balance after adrenal enucleation enucleation E. A. ALEXANDER of 02118 B. EISENSTEIN, Thorndike Memorial Laboratory, Renal Section, Boston City Hospital, and Departments Medicine and Physiology, Boston University School of Medicine, Boston, Massachusetts EISENSTEIN, B., H. H. BENGELE, AND E. A. ALEXANDER. Sodium balance after adrenal enucleation. Am. J. Physiol. 238 (Endocrinol. Metab. 1): E220-E222,1980.-To better define the relationship between adrenal enucleation (AE), sodium retention and adrenal regeneration hypertension (ARH), we measured daily sodium balance in rats after bilateral adrenal enucleation with (AEN) and without uninephrectomy (AE), and before and after development of ARH, along with the appropriate control groups. We found that both AE and AEN groups retained sodium during 7 days after surgery; AE 1.16 t 0.24 and AEN 1.32 * 0.33’ meq/lOO g body wt. Sham-operated, uninephrectomized rats and AE rats treated with spironolactone were in zero sodium balance. In the AEN rats after the development of ARH (BP > 150 Torr), zero sodium balance was also noted. Only AEN rats developed hypertension while sham-operated, uninephrectomized rats and AE rats with both kidneys remained normotensive for 28 wk. In summary, we have demonstrated that for 1 wk after AE, rats are in positive sodium balance and this is reversed by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

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Publisher
The American Physiological Society
Copyright
Copyright © 1980 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
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Abstract

enucleation E. A. ALEXANDER of 02118 B. EISENSTEIN, Thorndike Memorial Laboratory, Renal Section, Boston City Hospital, and Departments Medicine and Physiology, Boston University School of Medicine, Boston, Massachusetts EISENSTEIN, B., H. H. BENGELE, AND E. A. ALEXANDER. Sodium balance after adrenal enucleation. Am. J. Physiol. 238 (Endocrinol. Metab. 1): E220-E222,1980.-To better define the relationship between adrenal enucleation (AE), sodium retention and adrenal regeneration hypertension (ARH), we measured daily sodium balance in rats after bilateral adrenal enucleation with (AEN) and without uninephrectomy (AE), and before and after development of ARH, along with the appropriate control groups. We found that both AE and AEN groups retained sodium during 7 days after surgery; AE 1.16 t 0.24 and AEN 1.32 * 0.33’ meq/lOO g body wt. Sham-operated, uninephrectomized rats and AE rats treated with spironolactone were in zero sodium balance. In the AEN rats after the development of ARH (BP > 150 Torr), zero sodium balance was also noted. Only AEN rats developed hypertension while sham-operated, uninephrectomized rats and AE rats with both kidneys remained normotensive for 28 wk. In summary, we have demonstrated that for 1 wk after AE, rats are in positive sodium balance and this is reversed by

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Mar 1, 1980

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