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METHODS triiodothyronine; thermogenesis thyroxine; gland; catecholamines; from fetal to neonatal life there are profound changes in function in the human neonate resulting in markedly elevated plasma triiodothyronine (T3) levels. Similar events occur in the fetalneonatal lamb, providing a model to study in the perinatal period (6). By using this model we have reported that hepatic thyroxine (T4)-to-triiodothyronine (T3) converting activity (T, 5â-monodeiodinase activity, 5â-MDI) increases significantly in the perinatal period (15). A modest increase in serum T3 occurs during the 10 days immediately preceding parturition in the fetal sheep. This prepartum T3 increase occurs in association with the prepartum fetal cortisol surge and appears to be mediated by a cortisol-induced increase in hepatic V-MIDI (6, 9, 15). Extrauterine exposure evokes a second (postpartum) T3 surge, which is associated with a further increase in hepatic T4-to-T, conversion activity. In addition, we reported that the DURING THE TRANSITION 0193-1849/86 $1.50 Copyright Western, mixed-breed, time-dated, pregnant ewes (n = 5) with twin gestations were acclimated to laboratory conditions and fed a diet of pelletized alfalfa. Animals were handled and monitored humanely in supervised research facilities in accordance with National Institutes of Health guidelines. All were obtained from the Nebeker Ranch in
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Aug 1, 1986
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