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diography (12, 24, 28, 35), contrast ventriculography (17, 33), magnetic resonance imaging (MRI) (23), sonomicrometry (35,40,44,47). However, these studies were limited because they provided only unidimensional changes in the distance between natural /or artificial lmarks, therefore failing to account for oriented perpendicular to the direction defined by the lmarks (shearing) (48). In addition, unidimensional techniques do not permit the separation of rigidbody cardiac from myocardial (32). Both limitations are important because the heart moves as it contracts, the left ventricular wall undergoes complex patterns of during contraction relaxation. These limitations have greatly impaired the ability of echocardiography (26) other imaging modalities (14) to quantify changes in regional left ventricular function after myocardial ion. The placement of intramyocardial markers or sonomicrometers in a triangular (32) or tetrahedral (48) configuration has allowed the assessment of in two three dimensions during normal cardiac contraction (32,48), ventricular pacing (49), myocardial ischemia (46). However, previous studies utilizing implanted lmarks to assess myocardial in two or three dimensions have not examined the mechanical behavior of ed myocardial tissue beyond a few hours after coronary occlusion. MRI affords the possibility of tagging myocardial tissue noninvasively. Tissue tagging is achieved by changing the magnetization state of
AJP - Heart and Circulatory Physiology – The American Physiological Society
Published: Mar 1, 1995
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