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Role of protein kinase C and tyrosine kinase activity in IFN-gamma-induced expression of the class II MHC gene

Role of protein kinase C and tyrosine kinase activity in IFN-gamma-induced expression of the... 35294; histocompatibility complex (MHC) genes encode a group of highly polymorphic, noncovalently linked, cell surface glycoproteins. These molecules play a critical role in the induction of immune responses by present.ing antigen to T-cells, resulting in their activation and differentiation (1). The appropriate constitutive and inducible expression of class II MHC antigens is essential for normal immune function, whereas aberrant expression on cell types normally class II negative has been implicated in various autoimmune disorders (6, 19). The constitutive expression of class II MHC antigens is restricted primarily to B-cells, dendritic cells, thymic epithelium, and macrophages (13), although a variety of other cell types can be induced to express class II antigens after exposure to interferon-y (IFN-y), including pancreatic p-cells, keratinocytes, brain endothelial cells, microglia, and astrocytes (for review see Ref. 9). Regulation of class II gene expression occurs, for the most part, at the transcriptional level. In the proximal promoter regions of all class II genes studied, three highly conserved sequences have been identified: from 5’ to 3’ they are the W (Z, H, or S), X, and Y elements, respectively (for review see Ref. 9). The W box is a 30-bp sequence found immediately adjacent to the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Role of protein kinase C and tyrosine kinase activity in IFN-gamma-induced expression of the class II MHC gene

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
Publisher site
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Abstract

35294; histocompatibility complex (MHC) genes encode a group of highly polymorphic, noncovalently linked, cell surface glycoproteins. These molecules play a critical role in the induction of immune responses by present.ing antigen to T-cells, resulting in their activation and differentiation (1). The appropriate constitutive and inducible expression of class II MHC antigens is essential for normal immune function, whereas aberrant expression on cell types normally class II negative has been implicated in various autoimmune disorders (6, 19). The constitutive expression of class II MHC antigens is restricted primarily to B-cells, dendritic cells, thymic epithelium, and macrophages (13), although a variety of other cell types can be induced to express class II antigens after exposure to interferon-y (IFN-y), including pancreatic p-cells, keratinocytes, brain endothelial cells, microglia, and astrocytes (for review see Ref. 9). Regulation of class II gene expression occurs, for the most part, at the transcriptional level. In the proximal promoter regions of all class II genes studied, three highly conserved sequences have been identified: from 5’ to 3’ they are the W (Z, H, or S), X, and Y elements, respectively (for review see Ref. 9). The W box is a 30-bp sequence found immediately adjacent to the

Journal

AJP - Cell Physiology – The American Physiological Society

Published: Jan 1, 1995

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