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Role of angiotensin in ameliorating the renal actions of norepinephrine

Role of angiotensin in ameliorating the renal actions of norepinephrine HUN M. YANG THOMAS E. LOHMEIER Department of Physiology Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505 YANG, HUN M., THOMAS E. LOHMEIER. Role of angiotensin in ameliorating the actions of norepinephrine. Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R1497-R1506, 1991.-To determine the importance of the arterial pressure effects of angiotensin II (ANG II) on during acute adrenergic stimulation, we examined the effects of a 2-h intra arterial infusion of norepinephrine (NE) at 0.1 0.25 pg. kg-l. min-’ on in five conscious dogs during 1) control conditions, 2) servocontrol of arterial pressure (RAP) at control levels, 3) chronic captopril administration. The low rate of NE infusion produced an -20% decrease in glomerular filtration rate (GFR) plasma flow (RPF) an -8-mmHg increase in RAP in association with an -2.5fold rise in plasma renin activity (PRA). The high rate of NE infusion produced greater increments in both PRA RAP an -50% reduction in GFR RPF. Neither servo-control of RAP nor captopril administration significantly affected the above responses to the low rate of NE infusion. In marked contrast, when increases in RAP (-20 mmHg) were prevented at the high rate of NE infusion by servo-control of RAP, both http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

Role of angiotensin in ameliorating the renal actions of norepinephrine

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
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Abstract

HUN M. YANG THOMAS E. LOHMEIER Department of Physiology Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505 YANG, HUN M., THOMAS E. LOHMEIER. Role of angiotensin in ameliorating the actions of norepinephrine. Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R1497-R1506, 1991.-To determine the importance of the arterial pressure effects of angiotensin II (ANG II) on during acute adrenergic stimulation, we examined the effects of a 2-h intra arterial infusion of norepinephrine (NE) at 0.1 0.25 pg. kg-l. min-’ on in five conscious dogs during 1) control conditions, 2) servocontrol of arterial pressure (RAP) at control levels, 3) chronic captopril administration. The low rate of NE infusion produced an -20% decrease in glomerular filtration rate (GFR) plasma flow (RPF) an -8-mmHg increase in RAP in association with an -2.5fold rise in plasma renin activity (PRA). The high rate of NE infusion produced greater increments in both PRA RAP an -50% reduction in GFR RPF. Neither servo-control of RAP nor captopril administration significantly affected the above responses to the low rate of NE infusion. In marked contrast, when increases in RAP (-20 mmHg) were prevented at the high rate of NE infusion by servo-control of RAP, both

Journal

AJP - Regulatory, Integrative and Comparative Physiology – The American Physiological Society

Published: Dec 1, 1991

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