Response to letter to the editor by Gomez-Cabrera et al. J. O. Holloszy , K. Higashida , S. H. Kim , M. Higuchi , and D.-H. Han Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St. Louis, Missouri Address for reprint requests and other correspondence: J. O. Holloszy, Washington Univ. School of Medicine, Division of Geriatrics and Nutritional Sciences, Campus Box 8113, 4566 Scott Ave., St. Louis, MO 63110 (e-mail: jhollosz@dom.wustl.edu ). Submitted 23 November 2011. Accepted 25 November 2011. to the editor: In their Letter to the Editor regarding our paper [Higashida K, Kim SH, Higuchi M, Holloszy JO, Han D-H. Normal adaptations to exercise despite protection against oxidative stress ( 4 )], Gomez-Cabrera et al. ( 3a ) say, “Higashida et al. compared their data with ours and came to exactly the opposite conclusion, i.e., that antioxidant vitamin supplementation does not have an inhibitory effect on the adaptive responses of skeletal muscle to exercise.” In our study, we used standard methodology with which we have years of experience to evaluate the claim by Gomez-Cabrera et al. ( 3 ) and Ristow et al. ( 10 ) that antioxidant vitamins prevent the adaptive responses
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