Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Regulation of colonic ion transport by GRP. II. GRP modulates the epithelial response to PGE2

Regulation of colonic ion transport by GRP. II. GRP modulates the epithelial response to PGE2 Traynor, Tim R., and Scott M. O’Grady. Regulat of ic by . II. the epithelial response to PGEZ. Am. J. PhysioZ. 270 (CeZl PhysioZ. 39): C859-C865, 1996.-The purpose of this study was to examine the potential modulatory effects of gastrin-releasing peptide () on prostaglandin (PG) El>-stimulated electrolyte across the distal epithelium. In an earlier study, PGE2 was shown to reduce net Cl absorpt without altering the serosal-to-mucosal unidirectal Cl flux in porcine distal (19). present study, tissues were pretreated with serosal or mucosal and subsequently stimulated with PGEZ. The resulting increase in short-circuit current (I,,) was 152% (serosal ) and 49% (mucosal ) greater than control PGEZ responses alone. Serosal, but not mucosal, also enhanced the Isc response to vasoactive intestinal peptide. On the basis of flux measurements, the combined effects of serosal and PGE2 resulted activat of a transcellular pathway for Cl secret, which was not activated by either mediator alone. The time course of the PGE2 response was also affected by Serosal shortened the time to maximum I,c by 3X%, whereas mucosal peptide lengthened the time to maximum I,, by 68%. These results suggest that acts as a modulator of PG act on electrolyte distal . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Regulation of colonic ion transport by GRP. II. GRP modulates the epithelial response to PGE2

AJP - Cell Physiology , Volume 270: C859 – Mar 1, 1996

Loading next page...
 
/lp/the-american-physiological-society/regulation-of-colonic-ion-transport-by-grp-ii-grp-modulates-the-Hg4KVq1wuK

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
The American Physiological Society
Copyright
Copyright © 1996 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
Publisher site
See Article on Publisher Site

Abstract

Traynor, Tim R., and Scott M. O’Grady. Regulat of ic by . II. the epithelial response to PGEZ. Am. J. PhysioZ. 270 (CeZl PhysioZ. 39): C859-C865, 1996.-The purpose of this study was to examine the potential modulatory effects of gastrin-releasing peptide () on prostaglandin (PG) El>-stimulated electrolyte across the distal epithelium. In an earlier study, PGE2 was shown to reduce net Cl absorpt without altering the serosal-to-mucosal unidirectal Cl flux in porcine distal (19). present study, tissues were pretreated with serosal or mucosal and subsequently stimulated with PGEZ. The resulting increase in short-circuit current (I,,) was 152% (serosal ) and 49% (mucosal ) greater than control PGEZ responses alone. Serosal, but not mucosal, also enhanced the Isc response to vasoactive intestinal peptide. On the basis of flux measurements, the combined effects of serosal and PGE2 resulted activat of a transcellular pathway for Cl secret, which was not activated by either mediator alone. The time course of the PGE2 response was also affected by Serosal shortened the time to maximum I,c by 3X%, whereas mucosal peptide lengthened the time to maximum I,, by 68%. These results suggest that acts as a modulator of PG act on electrolyte distal .

Journal

AJP - Cell PhysiologyThe American Physiological Society

Published: Mar 1, 1996

There are no references for this article.