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Traynor, Tim R., and Scott M. OâGrady. Regulat of ic by . II. the epithelial response to PGEZ. Am. J. PhysioZ. 270 (CeZl PhysioZ. 39): C859-C865, 1996.-The purpose of this study was to examine the potential modulatory effects of gastrin-releasing peptide () on prostaglandin (PG) El>-stimulated electrolyte across the distal epithelium. In an earlier study, PGE2 was shown to reduce net Cl absorpt without altering the serosal-to-mucosal unidirectal Cl flux in porcine distal (19). present study, tissues were pretreated with serosal or mucosal and subsequently stimulated with PGEZ. The resulting increase in short-circuit current (I,,) was 152% (serosal ) and 49% (mucosal ) greater than control PGEZ responses alone. Serosal, but not mucosal, also enhanced the Isc response to vasoactive intestinal peptide. On the basis of flux measurements, the combined effects of serosal and PGE2 resulted activat of a transcellular pathway for Cl secret, which was not activated by either mediator alone. The time course of the PGE2 response was also affected by Serosal shortened the time to maximum I,c by 3X%, whereas mucosal peptide lengthened the time to maximum I,, by 68%. These results suggest that acts as a modulator of PG act on electrolyte distal .
AJP - Cell Physiology – The American Physiological Society
Published: Mar 1, 1996
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