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Regulation of ciliary beat frequency in airways: shear stress, ATP action, and its modulation Takashi Nakahari Department of Physiology, Osaka Medical College, Takatsuki, Japan MUCOCILIARY TRANSPORT IS a vital component of host defense and plays a crucial role in the removal of foreign materials within the airways. A dysfunction of ciliary beating can lead to serious respiratory problems such as airflow obstructions or Kartagener syndrome. The airway ciliary beat frequency (CBF) increases in response to a variety of stimulations, such as parasympathetic or sympathetic nervous stimulation, mechanical stimulation, hormones, etc. Winters et al., in one of the current articles in focus in this issue ( 8 ), highlighted shear stress as a physiological mechanism for CBF activation in the trachea. Since airway epithelia are continuously exposed to shear stress secondary to airflow, the focus of their report is the mechanism by which such stress can affect CBF. In their report ( 8 ), they show that repeated shear stress with caudal flow causes a large increase in CBF from 10 Hz to 25–35 Hz (37°C). These large CBF increases were induced by ATP released by shear, and this was associated with increases in intracellular Ca 2+ concentration ([Ca
AJP - Lung Cellular and Molecular Physiology – The American Physiological Society
Published: Mar 1, 2007
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