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Red cell deformation and fluidity of concentrated cell suspensions

Red cell deformation and fluidity of concentrated cell suspensions PIWSIOLOGY Vol. 27, No. 2, August Printed in U.S..4. Red cell deformation concentrated R. WELLS Departments and fluidity of cell suspensions AND H. SCHMID-SCHijNBEIN of Medicine, Harvard Medical School and Peter Bent Brigham Hospital, Boston! Massachusetts WELLS, K., AND H. SCHMID-SCH~~NBEIN. Red cell deformation and juidity of concentrated cell suspensions. J. Appl. Physiol. 27 (2) : 2 13-2 17. 1969; -The apparent viscosity of packed red cell suspensions ( >95 7; hematocrit) was measured at shear rates between 0.1 and 230 set-’ under both isosmolar conditions and after osmotic swelling and crenation (osmolarities between 170 and 750 mOsm/ liter). ‘The viscosity profiles of packed intact cells and freeze-thaw hemolysates were non-Newtonian as compared to the Newtonian behavior of hemoglobin. The packed cells showed the lowest viscosities under isosmolar conditions, with an increase after extreme swelling or crenation. The hemolysate showed the lowest viscosity under hyposmolar conditions. Viscosity increased progressively with increasing osmolarity or increasing hemoglobin concentration. The flow behavior of individual erythrocytes under the crowding conditions of cell packing was studied microscopically after dispersing intact cells in packed cell membranes (ghosts). The cells showed deformation under flow and a tank-treadlike motion of the membrane around the cell contents. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Red cell deformation and fluidity of concentrated cell suspensions

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Publisher
The American Physiological Society
Copyright
Copyright © 1969 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
Publisher site
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Abstract

PIWSIOLOGY Vol. 27, No. 2, August Printed in U.S..4. Red cell deformation concentrated R. WELLS Departments and fluidity of cell suspensions AND H. SCHMID-SCHijNBEIN of Medicine, Harvard Medical School and Peter Bent Brigham Hospital, Boston! Massachusetts WELLS, K., AND H. SCHMID-SCH~~NBEIN. Red cell deformation and juidity of concentrated cell suspensions. J. Appl. Physiol. 27 (2) : 2 13-2 17. 1969; -The apparent viscosity of packed red cell suspensions ( >95 7; hematocrit) was measured at shear rates between 0.1 and 230 set-’ under both isosmolar conditions and after osmotic swelling and crenation (osmolarities between 170 and 750 mOsm/ liter). ‘The viscosity profiles of packed intact cells and freeze-thaw hemolysates were non-Newtonian as compared to the Newtonian behavior of hemoglobin. The packed cells showed the lowest viscosities under isosmolar conditions, with an increase after extreme swelling or crenation. The hemolysate showed the lowest viscosity under hyposmolar conditions. Viscosity increased progressively with increasing osmolarity or increasing hemoglobin concentration. The flow behavior of individual erythrocytes under the crowding conditions of cell packing was studied microscopically after dispersing intact cells in packed cell membranes (ghosts). The cells showed deformation under flow and a tank-treadlike motion of the membrane around the cell contents.

Journal

Journal of Applied Physiology – The American Physiological Society

Published: Aug 1, 1969

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