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Radiation Effects on Cell Renewal and Related Systems

Radiation Effects on Cell Renewal and Related Systems HARVEY M. PATT AND HENRY QUASTLER Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, and Biology Department, Brookhaven National Laboratory, Won, Long Island, New York UCH OF THE EARLY WORK in radiation biology was predicated on the assumptionthat radiation effects could be understood in terms of a single mechanism. This “single mechanism” was studied on appropriate biological test objects that could be developed into biological dosimeters. Attempts were made to assess properties of the biological effect from the relations of the “biological dose” (skin dose, bean dose, fly dose, etc.) to physical parameters of irradiation. Notwithstanding the rigidity of this approach, someuseful generalizations emerged. During the past 20 years or so, it has become increasingly obvious that ionizing radiations may affect living systemsin different ways, and that what is true in one cell, tissue,or species and in one set of circumstances does not necessarily apply to another situation. Accordingly, the search for a single mechanism was replaced by dedicated application to specific detail. In consequence,we now know a great deal about the fine structure of someradiation effects, and there is once again a tendency to formulate generalizations. This paper will attempt to analyze the mechanism http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiological Reviews The American Physiological Society

Radiation Effects on Cell Renewal and Related Systems

Harvey M. Patt and Henry Quastler
Physiological Reviews , Volume 43: 357 – Jul 1, 1963
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Publisher
The American Physiological Society
Copyright
Copyright © 1963 the American Physiological Society
ISSN
0031-9333
eISSN
1522-1210
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Abstract

HARVEY M. PATT AND HENRY QUASTLER Division of Biological and Medical Research, Argonne National Laboratory, Argonne, Illinois, and Biology Department, Brookhaven National Laboratory, Won, Long Island, New York UCH OF THE EARLY WORK in radiation biology was predicated on the assumptionthat radiation effects could be understood in terms of a single mechanism. This “single mechanism” was studied on appropriate biological test objects that could be developed into biological dosimeters. Attempts were made to assess properties of the biological effect from the relations of the “biological dose” (skin dose, bean dose, fly dose, etc.) to physical parameters of irradiation. Notwithstanding the rigidity of this approach, someuseful generalizations emerged. During the past 20 years or so, it has become increasingly obvious that ionizing radiations may affect living systemsin different ways, and that what is true in one cell, tissue,or species and in one set of circumstances does not necessarily apply to another situation. Accordingly, the search for a single mechanism was replaced by dedicated application to specific detail. In consequence,we now know a great deal about the fine structure of someradiation effects, and there is once again a tendency to formulate generalizations. This paper will attempt to analyze the mechanism

Journal

Physiological Reviews – The American Physiological Society

Published: Jul 1, 1963

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