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Pulse wave propagation in rat renal tubules: implications for GFR autoregulation

Pulse wave propagation in rat renal tubules: implications for GFR autoregulation K., DONALD J. MARSH. Puke zuaue propagation in rat tubules: implications for GFR . Am. J. Physiol. 240 ( Fluid Electrolyte Physiol. 9): F446-F458, 1981.-To test whether macula densa feedback alone mediates blood flow (RBF) in rats, we imposed sudden increases (lo0 mmHg) in arterial pressure () compared the time courses of vascular resistance (RVR) changes of flow changes at the macula densa. RVR decreased abruptly after the increase, but returned to controevels in less than 1 s, continued to increase, reaching 50% completion within 3 s, achieved final values 150 s after the change. To predict transient changes in tubule flow, we derived a model of pressure flow combined it with measurements of tubule pressure made during steps. With these measured pressures as inputs, the model predicted a prompt rise in GFR followed by a decline that returned GFR halfway to control values within 3-4 s more slowly thereafter. Predicted early distal flow increased perceptibly only after 1 s rose slowly thenceforth. The disturbance in early distal flow pears to arrive too late to signal the rid changes in RVR. Some other mechanism, possibly myogenic, must have intervened. afferent arteriole; macula mathematical model densa; juxtaglomerular paratus; TWO http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Renal Physiology The American Physiological Society

Pulse wave propagation in rat renal tubules: implications for GFR autoregulation

D. K. Young and D. J. Marsh
AJP - Renal Physiology , Volume 240: F446 – May 1, 1981
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Publisher
The American Physiological Society
Copyright
Copyright © 1981 the American Physiological Society
ISSN
0363-6127
eISSN
1522-1466
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Abstract

K., DONALD J. MARSH. Puke zuaue propagation in rat tubules: implications for GFR . Am. J. Physiol. 240 ( Fluid Electrolyte Physiol. 9): F446-F458, 1981.-To test whether macula densa feedback alone mediates blood flow (RBF) in rats, we imposed sudden increases (lo0 mmHg) in arterial pressure () compared the time courses of vascular resistance (RVR) changes of flow changes at the macula densa. RVR decreased abruptly after the increase, but returned to controevels in less than 1 s, continued to increase, reaching 50% completion within 3 s, achieved final values 150 s after the change. To predict transient changes in tubule flow, we derived a model of pressure flow combined it with measurements of tubule pressure made during steps. With these measured pressures as inputs, the model predicted a prompt rise in GFR followed by a decline that returned GFR halfway to control values within 3-4 s more slowly thereafter. Predicted early distal flow increased perceptibly only after 1 s rose slowly thenceforth. The disturbance in early distal flow pears to arrive too late to signal the rid changes in RVR. Some other mechanism, possibly myogenic, must have intervened. afferent arteriole; macula mathematical model densa; juxtaglomerular paratus; TWO

Journal

AJP - Renal Physiology – The American Physiological Society

Published: May 1, 1981

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