Access the full text.
Sign up today, get DeepDyve free for 14 days.
I. Dobreva, G. Waeber, R. James, C. Widmann (2006)
Interleukin-8 Secretion by Fibroblasts Induced by Low Density Lipoproteins Is p38 MAPK-dependent and Leads to Cell Spreading and Wound Closure*Journal of Biological Chemistry, 281
M. Dwinell, N. Lügering, L. Eckmann, M. Kagnoff (2001)
Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells.Gastroenterology, 120 1
F. Dequiedt, J. Lint, Emily Lecomte, V. Duppen, T. Seufferlein, J. Vandenheede, R. Wattiez, R. Kettmann (2005)
Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor–induced Nur77 expression and apoptosisThe Journal of Experimental Medicine, 201
Laurence Levy, C. Neuveut, C. Renard, P. Charneau, S. Branchereau, F. Gauthier, J. Nhieu, D. Cherqui, Anne-France Petit-Bertron, D. Mathieu, M. Buendia (2002)
Transcriptional activation of interleukin-8 by beta-catenin-Tcf4.The Journal of biological chemistry, 277 44
J. Rubenfeld, Jia Guo, N. Sookrung, Rongbing Chen, W. Chaicumpa, V. Casolaro, Yutong Zhao, V. Natarajan, S. Georas (2006)
Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells.American journal of physiology. Lung cellular and molecular physiology, 290 1
C. Yun, Hong Sun, Dongsheng Wang, Raluca Rusovici, Amanda Castleberry, R. Hall, H. Shim (2005)
LPA2 receptor mediates mitogenic signals in human colon cancer cells.American journal of physiology. Cell physiology, 289 1
Sharon Matthews, Ping Liu, M. Spitaler, E. Olson, T. McKinsey, D. Cantrell, A. Scharenberg (2006)
Essential Role for Protein Kinase D Family Kinases in the Regulation of Class II Histone Deacetylases in B LymphocytesMolecular and Cellular Biology, 26
Laurence Levy, C. Neuveut, C. Renard, P. Charneau, S. Branchereau, F. Gauthier, J. Nhieu, D. Cherqui, Anne-France Petit-Bertron, D. Mathieu, M. Buendia (2002)
Transcriptional Activation of Interleukin-8 by β-Catenin-Tcf4*The Journal of Biological Chemistry, 277
Jingzhen Yuan, O. Rey, E. Rozengurt (2006)
Activation of protein kinase D3 by signaling through Rac and the alpha subunits of the heterotrimeric G proteins G12 and G13.Cellular signalling, 18 7
M. Raffatellu, Daniela Chessa, Daniela Chessa, R. Wilson, Richard Dusold, S. Rubino, A. Bäumler (2005)
The Vi Capsular Antigen of Salmonella enterica Serotype Typhi Reduces Toll-Like Receptor-Dependent Interleukin-8 Expression in the Intestinal MucosaInfection and Immunity, 73
Andreas Sturm, T. Sudermann, K. Schulte, H. Goebell, A. Dignass (1999)
Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid.Gastroenterology, 117 2
K. Mumy, B. McCormick (2005)
Events at the host-microbial interface of the gastrointestinal tract. II. Role of the intestinal epithelium in pathogen-induced inflammation.American journal of physiology. Gastrointestinal and liver physiology, 288 5
K. Page, Jing Li, Limei Zhou, Svetlana Iasvovskaia, K. Corbit, J. Soh, I. Weinstein, A. Brasier, A. Lin, M. Hershenson (2003)
Erratum: Regulation of airway epithelial cell NF-κB-dependent gene expression by protein kinase Cδ (Journal of Immunology (2003) 170 (5681-5689))Journal of Immunology, 171
A. Hausser, P. Storz, S. Märtens, G. Link, A. Toker, K. Pfizenmaier (2005)
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIβ at the Golgi complexNature Cell Biology, 7
C. Hurd, E. Rozengurt (2001)
Protein kinase D is sufficient to suppress EGF-induced c-Jun Ser 63 phosphorylation.Biochemical and biophysical research communications, 282 2
H. Oster, Diya Abraham, M. Leitges (2006)
Expression of the protein kinase D (PKD) family during mouse embryogenesis.Gene expression patterns : GEP, 6 4
P. Storz, Heike Döppler, A. Toker (2004)
Activation Loop Phosphorylation Controls Protein Kinase D-Dependent Activation of Nuclear Factor κBMolecular Pharmacology, 66
P. Camici, David Dutka (2001)
Repetitive stunning, hibernation, and heart failure: contribution of PET to establishing a link.American journal of physiology. Heart and circulatory physiology, 280 3
E. Hoffmann, O. Dittrich‐Breiholz, H. Holtmann, M. Kracht (2002)
Multiple control of interleukin‐8 gene expressionJournal of Leukocyte Biology, 72
C. Hurd, R. Waldron, E. Rozengurt (2002)
Protein kinase D complexes with C-Jun N-terminal kinase via activation loop phosphorylation and phosphorylates the C-Jun N-terminusOncogene, 21
D. Powell, P. Adegboyega, J. Mari, R. Mifflin (2005)
Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer.American journal of physiology. Gastrointestinal and liver physiology, 289 1
O. Rey, Jingzhen Yuan, E. Rozengurt (2003)
Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonists.Biochemical and biophysical research communications, 302 4
J. Mari, R. Mifflin, D. Powell (2005)
The role of protein kinase C in gastrointestinal function and disease.Gastroenterology, 128 7
E. Rozengurt, O. Rey, R. Waldron (2005)
Protein Kinase D Signaling*Journal of Biological Chemistry, 280
P. Storz, Heike Döppler, A. Toker (2005)
Protein Kinase D Mediates Mitochondrion-to-Nucleus Signaling and Detoxification from Mitochondrial Reactive Oxygen SpeciesMolecular and Cellular Biology, 25
S. Savkovic, A. Ramaswamy, A. Koutsouris, G. Hecht (2001)
EPEC-activated ERK1/2 participate in inflammatory response but not tight junction barrier disruption.American journal of physiology. Gastrointestinal and liver physiology, 281 4
E. Yeo, J. Exton (1995)
Stimulation of Phospholipase D by Epidermal Growth Factor Requires Protein Kinase C Activation in Swiss 3T3 Cells (*)The Journal of Biological Chemistry, 270
M. Frey, Marian Saxon, Xiaoyuan Zhao, Aisha Rollins, S. Evans, J. Black (1997)
Protein Kinase C Isozyme-mediated Cell Cycle Arrest Involves Induction of p21 waf1/cip1 and p27 kip1 and Hypophosphorylation of the Retinoblastoma Protein in Intestinal Epithelial Cells*
M. Moyer, L. Manzano, R. Merriman, J. Stauffer, L. Tanzer (1996)
NCM460, a normal human colon mucosal epithelial cell lineIn Vitro Cellular & Developmental Biology - Animal, 32
H. Koon, Dezheng Zhao, Yanai Zhan, S. Simeonidis, M. Moyer, C. Pothoulakis (2005)
Substance P-Stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cδ ActivationJournal of Pharmacology and Experimental Therapeutics, 314
Xiao-fu Wang, Qingding Wang, Wanqin Hu, B. Evers (2004)
Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-κB-dependent pathwayOncogene, 23
Carole Baron, V. Malhotra (2001)
Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma MembraneScience, 295
T. Milovanova, S. Chatterjee, Y. Manevich, I. Kotel’nikova, K. Debolt, M. Madesh, Jonni Moore, A. Fisher (2006)
Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species.American journal of physiology. Cell physiology, 290 1
Qingding Wang, Xiao-fu Wang, B. Evers (2003)
Induction of cIAP-2 in Human Colon Cancer Cells through PKCδ/NF-κB*Journal of Biological Chemistry, 278
Dezheng Zhao, Yanai Zhan, H. Zeng, H. Koon, M. Moyer, C. Pothoulakis (2005)
Neurotensin Stimulates Interleukin-8 Expression through Modulation of IκBα Phosphorylation and p65 Transcriptional Activity: Involvement of Protein Kinase CαMolecular Pharmacology, 67
Sabine Sturany, J. Lint, A. Gilchrist, J. Vandenheede, G. Adler, T. Seufferlein (2002)
Mechanism of Activation of Protein Kinase D2(PKD2) by the CCKB/Gastrin Receptor*The Journal of Biological Chemistry, 277
K. Asehnoune, D. Strassheim, Sanchayita Mitra, Jae-Yeol Kim, E. Abraham (2005)
Involvement of PKCα/β in TLR4 and TLR2 dependent activation of NF-κBCellular Signalling, 17
T. Chiu, E. Rozengurt (2001)
PKD in intestinal epithelial cells: rapid activation by phorbol esters, LPA, and angiotensin through PKC.American journal of physiology. Cell physiology, 280 4
K. Page, Jing Li, Limei Zhou, Svetlana Iasvoyskaia, K. Corbit, J. Soh, I. Weinstein, A. Brasier, A. Lin, M. Hershenson (2003)
Regulation of Airway Epithelial Cell NF-κB-Dependent Gene Expression by Protein Kinase Cδ1The Journal of Immunology, 170
Yutong Zhao, D. He, B. Saatian, T. Watkins, E. Spannhake, N. Pyne, V. Natarajan (2006)
Regulation of Lysophosphatidic Acid-induced Epidermal Growth Factor Receptor Transactivation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells by Protein Kinase Cδ, Lyn Kinase, and Matrix Metalloproteinases*Journal of Biological Chemistry, 281
R. Izzo, K. Witkon, A. Chen, C. Hadjiyane, M. Weinstein, C. Pellecchia (1992)
Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis.The American journal of gastroenterology, 87 10
E. Cario, G. Gerken, D. Podolsky (2004)
Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C.Gastroenterology, 127 1
C. Abraham, B. Scaglione–Sewell, S. Skarosi, W. Qin, M. Bissonnette, T. Brasitus (1998)
Protein kinase C α modulates growth and differentiation in Caco-2 cellsGastroenterology, 114
Protein Kinase C (cid:2) Selectively Regulates Protein Kinase D-Dependent Activation of NF- (cid:3) B in Oxidative Stress Signaling
J. Sinnett-Smith, E. Zhukova, Nena Hsieh, Xiaohua Jiang, E. Rozengurt (2004)
Protein Kinase D Potentiates DNA Synthesis Induced by Gq-coupled Receptors by Increasing the Duration of ERK Signaling in Swiss 3T3 Cells*Journal of Biological Chemistry, 279
P. Storz, A. Toker (2003)
Protein kinase D mediates a stress‐induced NF‐κB activation and survival pathwayThe EMBO Journal, 22
M. Abreu, M. Fukata, M. Arditi (2005)
TLR Signaling in the Gut in Health and Disease1The Journal of Immunology, 174
Ya‐Jen Chang, Ming-Shiang Wu, Jaw-Town Lin, B. Sheu, T. Muta, H. Inoue, Ching‐Chow Chen (2004)
Induction of Cyclooxygenase-2 Overexpression in Human Gastric Epithelial Cells by Helicobacter pylori Involves TLR2/TLR9 and c-Src-Dependent Nuclear Factor-κB ActivationMolecular Pharmacology, 66
O. Rey, Jingzhen Yuan, S. Young, E. Rozengurt (2003)
Protein Kinase Cν/Protein Kinase D3 Nuclear Localization, Catalytic Activation, and Intracellular Redistribution in Response to G Protein-coupled Receptor Agonists*Journal of Biological Chemistry, 278
Sabine Sturany, J. Lint, F. Müller, M. Wilda, H. Hameister, M. Höcker, A. Brey, U. Gern, J. Vandenheede, T. Gress, G. Adler, T. Seufferlein (2001)
Molecular Cloning and Characterization of the Human Protein Kinase D2 A NOVEL MEMBER OF THE PROTEIN KINASE D FAMILY OF SERINE THREONINE KINASES*
Qingding Wang, Xiao-fu Wang, B. Evers (2003)
Induction of cIAP-2 in human colon cancer cells through PKC delta/NF-kappa B.The Journal of biological chemistry, 278 51
A. Hayashi, Naohiko Seki, A. Hattori, S. Kozuma, Toshiyuki Saito (1999)
PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu.Biochimica et biophysica acta, 1450 1
M. Liljedahl, Y. Maeda, A. Colanzi, I. Ayala, J. Lint, V. Malhotra (2001)
Protein Kinase D Regulates the Fission of Cell Surface Destined Transport Carriers from the Trans-Golgi NetworkCell, 104
G. Perletti, E. Marras, P. Concari, F. Piccinini, A. Tashjian (1999)
PKCδ acts as a growth and tumor suppressor in rat colonic epithelial cellsOncogene, 18
L. Mazzucchelli, C. Hauser, K. Zgraggen, Hans, Wagner, Max Hess, J. Laissue, C. Mueller (1994)
Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation.The American journal of pathology, 144 5
B. Anliker, J. Chun (2004)
Lysophospholipid G Protein-coupled Receptors*Journal of Biological Chemistry, 279
E. Zhukova, J. Sinnett-Smith, E. Rozengurt (2001)
Protein Kinase D Potentiates DNA Synthesis and Cell Proliferation Induced by Bombesin, Vasopressin, or Phorbol Esters in Swiss 3T3 Cells*The Journal of Biological Chemistry, 276
A. Satoh, A. Gukovskaya, J. Reeve, T. Shimosegawa, S. Pandol (2006)
Ethanol sensitizes NF-κB activation in pancreatic acinar cells through effects on protein kinase C-εAmerican Journal of Physiology-gastrointestinal and Liver Physiology, 291
B. Saatian, Yutong Zhao, D. He, S. Georas, T. Watkins, E. Spannhake, V. Natarajan (2006)
Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells.The Biochemical journal, 393 Pt 3
D. Shida, J. Kitayama, H. Yamaguchi, Y. Okaji, N. Tsuno, Toshiaki Watanabe, Y. Takuwa, H. Nagawa (2003)
Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.Cancer research, 63 7
N. Murray, L. Davidson, R. Chapkin, W. Gustafson, D. Schattenberg, A. Fields (1999)
Overexpression of Protein Kinase C βII Induces Colonic Hyperproliferation and Increased Sensitivity to Colon CarcinogenesisThe Journal of Cell Biology, 145
O. Lorentz, A. Cadoret, I. Duluc, J. Capeau, C. Gespach, G. Cherqui, J. Freund (1999)
Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic rasOncogene, 18
D. Toullec, P. Pianetti, H. Coste, P. Bellevergue, T. Grand‐Perret, M. Ajakane, V. Baudet, P. Boissin, Eric Boursier, F. Loriolle (1991)
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.The Journal of biological chemistry, 266 24
Hsinyu Lee, Chi Lin, J. Liao, Yu‐Wei Lee, H. Yang, Chung-Ying Lee, Hsien-Yeh Hsu, Hua-Lin Wu (2004)
Lysophospholipids increase ICAM-1 expression in HUVEC through a Gi- and NF-kappaB-dependent mechanism.American journal of physiology. Cell physiology, 287 6
C. Bagowski, M. Stein-Gerlach, A. Choidas, A. Ullrich (1999)
Cell‐type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptorThe EMBO Journal, 18
Tamara Mihailovic, M. Marx, A. Auer, J. Lint, M. Schmid, C. Weber, T. Seufferlein (2004)
Protein Kinase D2 Mediates Activation of Nuclear Factor κB by Bcr-Abl in Bcr-Abl+ Human Myeloid Leukemia CellsCancer Research, 64
Q. Huynh, T. McKinsey (2006)
Protein kinase D directly phosphorylates histone deacetylase 5 via a random sequential kinetic mechanism.Archives of biochemistry and biophysics, 450 2
Ming-Zhen Yang, W. Zhong, N. Srivastava, A. Slavin, Jianxin Yang, T. Hoey, S. An (2005)
G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathwayProceedings of the National Academy of Sciences of the United States of America, 102
The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD 2 activation and the potential contribution of PKD 2 in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined. Treatment of serum-deprived NCM460 cells with LPA led to a rapid and striking activation of PKD 2 , as measured by in vitro kinase assay and phosphorylation at the activation loop (Ser706/710) and autophosphorylation site (Ser876). PKD 2 activation induced by LPA was abrogated by preincubation with selective PKC inhibitors GF-I and Ro-31-8220 in a dose-dependent manner. These inhibitors did not have any direct inhibitory effect on PKD 2 activity. LPA induced a striking increase in IL-8 production and stimulated NF-κB activation, as measured by NF-κB-DNA binding, NF-κB-driven luciferase reporter activity, and IκBα phosphorylation. PKD 2 gene silencing utilizing small interfering RNAs targeting distinct PKD 2 sequences dramatically reduced LPA-stimulated NF-κB promoter activity and IL-8 production. PKD 2 activation is a novel early event in the biological action of LPA and mediates LPA-stimulated IL-8 secretion in NCM460 cells through a NF-κB-dependent pathway. Our results demonstrate, for the first time, the involvement of a member of the PKD family in the production of IL-8, a potent proinflammatory chemokine, by epithelial cells. NCM460 cells; protein kinase C; CXCL8; phorbol esters Address for reprint requests and other correspondence: E. Rozengurt, 900 Veteran Ave., Warren Hall, Rm. 11–144, Dept. of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1786 (e-mail: erozengurt@mednet.ucla.edu )
AJP - Cell Physiology – The American Physiological Society
Published: Feb 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.