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Preoptic-hypothalamic periventricular lesions reduce natriuresis to volume expansion

Preoptic-hypothalamic periventricular lesions reduce natriuresis to volume expansion 0363-6119/83/0000-0000$0.150 Copyright 0 1983 the American Physiological Society R51 R52 could alter renal sodium reabsorption. The results indicate that the integrity AV3V periventricular tissue is essential for a normal natriuretic response following extracellular fluid volume expansion. Furthermore, the inhibited natriuresis may be at least partially due to a decreased release or activation a natriuretic factor, regulated through this specific area the brain. METHODS ET AL. Animals Male Sprague-Dawley rats were housed individually in a room maintained at 22OC and on a light-dark cycle (LD 12:lZ). All animals had ad libitum access to food and water. Lesions Animals underwent either electrolytic ablation the periventricular tissue surrounding the AV3V or control surgical procedures using techniques described in detail elsewhere (2, 3,9). Rats to be lesioned were anesthetized with ether and mounted in a Kopf stereotaxic instrument. A midline scalp incision was made and the fascia cleared. After the skull had been leveled between lambda and bregma, a Z-mm hole centered about bregma was drilled. Following removal bone, the medial sag&al sinus was retracted laterally to allow midline penetration the lesioning electrode without excessive bleeding. Electrodes were made from 24-gauge nichrome wire insulated with Beldenamel except for 0.5 mm at the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Regulatory, Integrative and Comparative Physiology The American Physiological Society

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Publisher
The American Physiological Society
Copyright
Copyright © 1983 the American Physiological Society
ISSN
0363-6119
eISSN
1522-1490
Publisher site
See Article on Publisher Site

Abstract

0363-6119/83/0000-0000$0.150 Copyright 0 1983 the American Physiological Society R51 R52 could alter renal sodium reabsorption. The results indicate that the integrity AV3V periventricular tissue is essential for a normal natriuretic response following extracellular fluid volume expansion. Furthermore, the inhibited natriuresis may be at least partially due to a decreased release or activation a natriuretic factor, regulated through this specific area the brain. METHODS ET AL. Animals Male Sprague-Dawley rats were housed individually in a room maintained at 22OC and on a light-dark cycle (LD 12:lZ). All animals had ad libitum access to food and water. Lesions Animals underwent either electrolytic ablation the periventricular tissue surrounding the AV3V or control surgical procedures using techniques described in detail elsewhere (2, 3,9). Rats to be lesioned were anesthetized with ether and mounted in a Kopf stereotaxic instrument. A midline scalp incision was made and the fascia cleared. After the skull had been leveled between lambda and bregma, a Z-mm hole centered about bregma was drilled. Following removal bone, the medial sag&al sinus was retracted laterally to allow midline penetration the lesioning electrode without excessive bleeding. Electrodes were made from 24-gauge nichrome wire insulated with Beldenamel except for 0.5 mm at the

Journal

AJP - Regulatory, Integrative and Comparative PhysiologyThe American Physiological Society

Published: Jan 1, 1983

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