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Plasma endothelin and renal endothelin are two distinct systems involved in volume homeostasis

Plasma endothelin and renal endothelin are two distinct systems involved in volume homeostasis (ET)-1 is a peptide isolated from the culture medium of porcine aortic cells whose mRNA is widely expressed in human endothelial cells (20). Three distinct isoforms, ET-l, ET-2, ET-3, have been identified. Endothelin synthesis is not limited to the vascular endothelium; other types of cells, including those of the lung, kidney, gut, can synthesize endothelin (8, 10, 18). Abundant expression of ET-l peptide the mRNA of its precursor, prepro-ET-l, have been found not only in the vascular endothelium of the renal vascular bed, including the glomerular capillaries arterioles the peritubular capillaries (10, 12, 13), but also in high concentration in the inner medullary collecting duct (8). The biological activities of the endothelins are mediated by at least two distinct endothelin receptors, designated ETA ETB (20), which are widely distributed in a number of tissues, most notably the vascular wall, heart, lung, kidney (20). ET* is highly sensitive to ET-1 ET-2, but all three endothelin isopeptides have equal finity for ET B. ETA, which is found on smooth muscle cells, mediates constriction, whereas ETB is found on endothelial cells mediates the production of endothelium-derived relaxing factor (20). ENDOTHELIN 0363-6135/95 $3.00 Copyright 0 1995 Early characterization studies of ET-1 revealed http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Heart and Circulatory Physiology The American Physiological Society

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Publisher
The American Physiological Society
Copyright
Copyright © 1995 the American Physiological Society
ISSN
0363-6135
eISSN
1522-1539
Publisher site
See Article on Publisher Site

Abstract

(ET)-1 is a peptide isolated from the culture medium of porcine aortic cells whose mRNA is widely expressed in human endothelial cells (20). Three distinct isoforms, ET-l, ET-2, ET-3, have been identified. Endothelin synthesis is not limited to the vascular endothelium; other types of cells, including those of the lung, kidney, gut, can synthesize endothelin (8, 10, 18). Abundant expression of ET-l peptide the mRNA of its precursor, prepro-ET-l, have been found not only in the vascular endothelium of the renal vascular bed, including the glomerular capillaries arterioles the peritubular capillaries (10, 12, 13), but also in high concentration in the inner medullary collecting duct (8). The biological activities of the endothelins are mediated by at least two distinct endothelin receptors, designated ETA ETB (20), which are widely distributed in a number of tissues, most notably the vascular wall, heart, lung, kidney (20). ET* is highly sensitive to ET-1 ET-2, but all three endothelin isopeptides have equal finity for ET B. ETA, which is found on smooth muscle cells, mediates constriction, whereas ETB is found on endothelial cells mediates the production of endothelium-derived relaxing factor (20). ENDOTHELIN 0363-6135/95 $3.00 Copyright 0 1995 Early characterization studies of ET-1 revealed

Journal

AJP - Heart and Circulatory PhysiologyThe American Physiological Society

Published: May 1, 1995

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