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THE CALORIGENIC EFFECT of was first described in 1903 (23). Since then many studies have verified âs stimulatory effect on (19). In virtually all of these experiments pharmacological amounts of were administered with the exception of the study of Cori and Buckwald (11) who found d O2 consumption in humans during an intravenous infusion of at s that have subsequently been shown to elevate venous plasma concentrations to the range of 300-400 pg/ml (9)) high associated with stressful events such as prolonged exercise (15) or severe hypoglycemia (17). However, during the normal activities of daily living, venous plasma concentrations are much lower than the previously studied 300-400 pg/ml. InE322 0193-1849/87 $1.50 Copyright If, in fact, stimulates at plasma of 100 pg/ml, might be important in determining caloric requirements. A decrease in the response to could contribute to the develoent of obesity, and conversely an in the response could lower body weight. To more precisely define the threshold, we investigated the effect of very low infusion s (0.1, 0.5, and 1.0 pg/min) on . Additionally, to aid definition of threshold, we also studied the hourly and daily variability in within individual subjects. METHODS Subjects Young men, within 20% of
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Sep 1, 1987
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