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U.S.A. 19X Permeability RQBERT Department of the Skin IRVIN H. Generai J. of Dermatology, Harvard Medical School at the Massachusetts Hospital, Boston, Massachusetts Introduction ............................................................. ........................................................... Past reviews. Historical summary (1850- 1950) .......................................... Recent work (1950-present) : outline of major concepts. ...................... Structure of the Skin as a Permeability Barrier ................................ Relevant structural features of whole skin. ................................. ........................................... Structure of stratum corneum. ......................................... Regional variations in structure. Methods Procedures for Measuring Analyzing Skin Permeability. ................................................ Experimental techniques. Mathematical analysis of permeability data. ............................... .................................................. Definitions of symbols. ............................................ Biophysics of Skin Permeability. Permeability of aqueous solutions of alcohols ............................... ......................................... Mechanisms of skin permeability. Permeability of Different Classes of Compounds. .............................. ...................................... Permeability from aqueous solutions. .................................. Permeability from nonaqueous solutions. Permeability of gases. ................................................... Conclusion .............................................................. ....... IN TRODUCTION Interest in skin permeability arises mainly from the capacity of the skin to limit the bodys accumulation (or elimination) of substances by percutaneous transport. The epidermal skin barrier is the major factor in this process can reduce overall rates of accumulation by several orders of magnitude. For example, most water-soluble, low-molecular-weight nonelectrolytes applied to the skin surface could diffuse into the bloodstream approximately 1000 times more rapidly
Physiological Reviews – The American Physiological Society
Published: Oct 1, 1971
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