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Oxytocin affects apical sodium conductance in rabbit cortical collecting duct

Oxytocin affects apical sodium conductance in rabbit cortical collecting duct sites have been demstrated in the inner medullary collecting (33), macula dea (32), and paraglomerular structures (37) by autoradiographic studies of the rat kidney. e report renal tubular epithelial LLC-PK1 claims that OT enhances phosphoinositide hydrolysis and increases intracellular free calcium ( [Ca2+]J (31); other investigators have reported that OT increases the proi of adenosine 3’,5’-cyclic mophosphate (CAMP) or cGMP in the same (18). In ctrast, it has been reported that arginine vasopressin (AVP) binds OT receptors in cultured rat inner medullary collecting with high affinity (35), raising the possibility that some of the renal effects of AVP may be explained by its acti through OT receptors. Because there has been no direct evidence of the physiological role of OT in the renal tubules, we designed this study to 1) clarify the tubular acti of OT, 2) determine whether the tubular acti of OT is via AVP receptors, and 3) clarify the mechanisms by which OT exerts its tubular acti. Therefore, we used an isolated rabbit microperfused collecting (CCD) model and measured the iic cances of the cell membrane by using electrophysiological techniques. [Ca2+]i was also measured, with the acetoxymethyl ester (AM) of fura 2. MATERIALS AND METHODS http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Renal Physiology The American Physiological Society

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