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Osmotic stability of red cells in renal circulation requires rapid urea transport

Osmotic stability of red cells in renal circulation requires rapid urea transport METHODS erythrocyte; renal medulla HUMAN RED BLOOD CELL contains many systems for moving ions and nonelectrolytes across its membrane. Many of these systems have been shown to be important for the physiological functions of the whole organism as well as the cell itself. The discovery that and water movements are independent (11,12) and that follows facilitated kinetics rather than passive diffusion kinetics (L. Wadzinski and R. Macey, unpublished observations, 1,9,14,22) is puzzling when viewed from a teleological perspective. Why should the red blood cell evolve a system to move ly across its membrane when the average concentration in the blood is normally so low? In this paper, we give a plausible advantage for evolution of this system. In the kidney, where the vasa recta capillaries dip down into the medulla exposing the cells to high salt and concentrations, the cells would be close to hypertonic hemolysis at the medullary tip and emerge from the medulla loaded with and swollen if a fast system were not present. Our aim is to compare cell volume and internal concentration as cells move through and out of the vasa THE Simple diffusion case. As a red blood cell descends into the renal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Cell Physiology The American Physiological Society

Osmotic stability of red cells in renal circulation requires rapid urea transport

AJP - Cell Physiology , Volume 254: C669 – May 1, 1988

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Publisher
The American Physiological Society
Copyright
Copyright © 1988 the American Physiological Society
ISSN
0363-6143
eISSN
1522-1563
Publisher site
See Article on Publisher Site

Abstract

METHODS erythrocyte; renal medulla HUMAN RED BLOOD CELL contains many systems for moving ions and nonelectrolytes across its membrane. Many of these systems have been shown to be important for the physiological functions of the whole organism as well as the cell itself. The discovery that and water movements are independent (11,12) and that follows facilitated kinetics rather than passive diffusion kinetics (L. Wadzinski and R. Macey, unpublished observations, 1,9,14,22) is puzzling when viewed from a teleological perspective. Why should the red blood cell evolve a system to move ly across its membrane when the average concentration in the blood is normally so low? In this paper, we give a plausible advantage for evolution of this system. In the kidney, where the vasa recta capillaries dip down into the medulla exposing the cells to high salt and concentrations, the cells would be close to hypertonic hemolysis at the medullary tip and emerge from the medulla loaded with and swollen if a fast system were not present. Our aim is to compare cell volume and internal concentration as cells move through and out of the vasa THE Simple diffusion case. As a red blood cell descends into the renal

Journal

AJP - Cell PhysiologyThe American Physiological Society

Published: May 1, 1988

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