Cell death is regulated by a myriad of intracellular molecular pathways, with many involving protein phosphorylation and dephosphorylation. In this review, we will focus on Ser/Thr phosphatases-mediated regulation in cell apoptosis as well as on their potential roles in cell necrosis. The emerging functional importance of Ser/Thr protein phosphatases in cell death regulation adds new dimension to the signaling mechanisms of cellular function, physiology, and diseases. Footnotes This work is supported in part by National Heart, Lung, and Blood Institute Grants HL-108186, HL-103205, HL-098954. H. Sun is supported by AHA post doc fellowship (Great Western Affiliate) and AHA Science Development Grant (National Research Center). No conflicts of interest, financial or otherwise, are declared by the author(s). Author contributions: H.S. and Y.W. conception and design of research; H.S. and Y.W. analyzed data; H.S. and Y.W. prepared figures; H.S. and Y.W. drafted the manuscript; H.S. and Y.W. edited and revised the manuscript; H.S. and Y.W. approved the final version of the manuscript. ©2012 Int. Union Physiol. Sci./Am. Physiol. Soc. « Previous Table of Contents This Article doi: 10.1152/physiol.00034.2011 Physiology February 2012 vol. 27 no. 1 43-52 » Abstract Free Full Text Free to you Full Text (PDF) Free to you Classifications Review Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Sun, H. Articles by Wang, Y. PubMed Articles by Sun, H. Articles by Wang, Y. Related Content Load related web page information Current Issue February 2012, 27 (1) Alert me to new issues of Physiology About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 1548-9213 Online ISSN: 1548-9221 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();
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Novel Ser/Thr Protein Phosphatases in Cell Death Regulation
Sun, Haipeng; Wang, Yibin
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, Volume 27 (1): 43
The American Physiological Society – Feb 1, 2012
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