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Novel Mechanisms in the Regulation of Phosphorus Homeostasis

Novel Mechanisms in the Regulation of Phosphorus Homeostasis Abstract Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concentrations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus. Review discussing how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus. Copyright © 2009 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Physiology The American Physiological Society

Novel Mechanisms in the Regulation of Phosphorus Homeostasis

Physiology , Volume 24 (1): 17 – Feb 1, 2009

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References (87)

Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
1548-9213
eISSN
1548-9221
DOI
10.1152/physiol.00034.2008
pmid
19196648
Publisher site
See Article on Publisher Site

Abstract

Abstract Phosphorus plays a critical role in diverse biological processes, and, therefore, the regulation of phosphorus balance and homeostasis are critical to the well being of the organism. Changes in environmental, dietary, and serum concentrations of inorganic phosphorus are detected by sensors that elicit changes in cellular function and alter the efficiency by which phosphorus is conserved. Short-term, post-cibal responses that occur independently of hormones previously thought to be important in phosphorus homeostasis may play a larger role than previously appreciated in the regulation of phosphorus homeostasis. Several hormones and regulatory factors such as the vitamin D endocrine system, parathyroid hormone, and the phosphatonins (FGF-23, sFRP-4, MEPE) among others, may play a role only in the long-term regulation of phosphorus homeostasis. In this review, we discuss how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus. Review discussing how organisms sense changes in phosphate concentrations and how changes in hormonal factors result in the conservation or excretion of phosphorus. Copyright © 2009 the American Physiological Society

Journal

PhysiologyThe American Physiological Society

Published: Feb 1, 2009

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