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DAVID PHILIP OYER Stanford University Medical Center, Stanford, California , DAVID, PHILIP OYER. -stimulated acute chronic . Am. J. Physiol. 241 (Endocrol. Metab. 4): E28-E34, 1981.-The effects of acute chronic on -stimulated were studied . Right-to-left shunts were created experimental to render them chronically hypoxemic (Pao, 37-55 torr). animals received sham operations (Pa+ >70 torr). Durg air ventilation, there was no significant difference -duced glycerol free fatty acid (FFA) rises the experimental groups. , glycerol FFA responses to were unaffected by acutely lowerg oxygen tensions (Pao, 4648 torr) to levels found air-breathg experimental . However, greater acute reductions oxygen tensions (Pao, < 30 torr) both experimental animals resulted pronounced glycerol FFA falls from the elevated levels produced by fusions durg air ventilation. Pao, levels < 30 torr similarly decreased the glycerol FFA elevations animals given phenoxybenzame . As with severe , propranolol suppressed glycerol FFA creases stimulated by . Theophylle did not fluence the hypoxemic-duced glycerol FFA falls. These observations suggest that severity was important the hypoxemic hibition of -stimulated ; the effects of low oxygen breathg were not ameliorated by chronic . A P-adrenergic receptor abnormality appears to contribute to this hibition. ysis, admistered to mammals produces
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Jul 1, 1981
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