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Department Medicine, Faculty Mammalian Dental Tokyo Medical UrLiversity, Tokyo, Japan Pharmacology, I. Introduction ......................................................................................... II. Early History Substance P ....................................................................... ............................. III. Neuro Role Substance P in Primary Afferent Neurons A. Development neuro concept for substance P ..................................... B. Evidence for substance P as a sensory in spinal cord ............................. .................................................... C. Role substance P in prevertebral ganglia IV. Cellular Molecular Aspects Tachykinin ............................................. A. Mammalian , their precursors genes ........................................... B. Tachykinin receptors ............................................................................ ........................................ C. Structure-activity relationship tachykinin agonists D. Tachykinin antagonists .......................................................................... E. Biosynthesis, storage, axonal transport .................................... ........................................................................... F. Release G. Capsaicin ......................................................................................... H. Cellular mechanisms tachykinin actions ..................................................... I. Inactivation mechanisms ........................................................ ....................................................... J. Long-term changes in tachykinin K. Coexistence with other neuros ...................................... V. in the Central Nervous ......................................... ........................................................................................ A. Neocortex B. Striatum pallidum .......................................................................... C. Substantia nigra ventral tegmental area ................................................... D. Nucleus accumbens .............................................................................. E. Nucleus basalis Meynert ...................................................................... F. Some structures in limbic ............................................................... G. Hypothalamus pituitary gl .............................................................. H. Thalamus ......................................................................................... I. Spinal trigeminal nucleus ....................................................................... J. Dorsal vagal complex ............................................................................ K. Other nuclei in brain stem ....................................................................... L. Autonomic preganglionic nuclei ................................................................. M. Ventral horn cranial motor nuclei .......................................................... N. Glia ............................................................................................... VI. in Peripheral Tissues
Physiological Reviews – The American Physiological Society
Published: Apr 1, 1993
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