Abstract Previous research demonstrates that our apparent mental flexibility depends largely on the strength of our prior intention; changing our intention in advance enables a smooth transition from one task to another (e.g., Astle DE, Jackson GM, Swainson R. J Cogn Neurosci 20: 255–267, 2008; Duncan J, Emslie H, Williams P, Johnson R, Freer C. Cogn Psychol 30: 257–303, 1996; Husain M, Parton A, Hodgson TL, Mort D, Rees G. Nat Neurosci 6: 117–118, 2003). However, these necessarily rapid anticipatory mechanisms have been difficult to study in the human brain. We used EEG and magnetoencephalography, specifically event-related potentials and fields (ERPs and ERFs), respectively, to explore the neural correlates of this important aspect of mental flexibility. Subjects performed a manual version of a pro/antisaccade task using preparatory cues to switch between the pro- and antirules. When subjects switched their intention, we observed a positivity over central electrodes, which correlated significantly with our behavioral data; the greater the ERP effect, the stronger the subject's change of intention. ERFs, alongside subject-specific structural MRIs, were used to project into source space. When subjects switched their intention, they showed significantly elevated activity in the right frontal eye field and left intraparietal sulcus (IPS); the greater the left IPS activity on switch trials, the stronger the subject's change of intention. This network has previously been implicated in the top-down control of eye movements, but here we demonstrate its role in the top-down control of a task set, in particular, that it is recruited when we change the task that we intend to perform. cognitive control event-related potentials executive control task switching Copyright © 2012 the American Physiological Society « Previous | Next Article » Table of Contents This Article Published online before print November 2011 , doi: 10.​1152/​jn.​00604.​2011 AJP - JN Physiol February 2012 vol. 107 no. 3 859-867 » Abstract Free Full Text Free to you Full Text (PDF) Free to you All Versions of this Article: jn.00604.2011v1 107/3/859 most recent Classifications Article Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Citing articles via Web of Science Google Scholar Articles by Astle, D. E. Articles by Jackson, G. M. PubMed PubMed citation Articles by Astle, D. E. Articles by Jackson, G. M. Related Content Load related web page information Current Issue February 2012, 107 (3) Alert me to new issues of AJP - JN Physiol About the Journal Information for Authors Submit a Manuscript Ethical Policies AuthorChoice PubMed Central Policy Reprints and Permissions Advertising Press Copyright © 2012 the American Physiological Society Print ISSN: 0022-3077 Online ISSN: 1522-1598 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-2924550-1"); pageTracker._trackPageview();

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