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NATURE OF THE "ENDPLATE POTENTIAL" IN CURARIZED MUSCLE

NATURE OF THE "ENDPLATE POTENTIAL" IN CURARIZED MUSCLE OF THE “ENDPLATE POTENTIAL” IN CURARIZED MUSCLE BERNHARD litstitute for KATZ* of Pathology, AND STEPHEN Sydney Hospital, 30, 1941) W. KUFFLER Sydney Memorial (Received publication January transmission may be divided into four successive stages: (i .) the process whereby the nerve impulse gives rise to the transmitting agents; (ii) the nature of the transmitter, and the mode of its action and subsequent inactivation; (iii) the local changes set up at the junctional region of the muscle fibre; (iv) the initiation of a propagated muscle impulse by these local changes. The present inves Itigation deals with the la ter phases of the transm ission process (problems iii and iv above) . During a state of neuromuscular block by curare, local action potentials can be recorded at the junctional region of the muscle. Their properties and their relation to the propagating impulse have been studied in detail in this and following papers. The evidence so obtained concerns primarily the initiation of the muscle impulse, but indirectly throws some light also on the transmitter problem (No. ii above). METHODS THE PROBLEM of neuro-muscular For an electrical study of neuro-muscular transmission, it would be desirable to work on a completely isolated nerve-muscle http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neurophysiology The American Physiological Society

NATURE OF THE "ENDPLATE POTENTIAL" IN CURARIZED MUSCLE

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Publisher
The American Physiological Society
Copyright
Copyright © 1941 the American Physiological Society
ISSN
0022-3077
eISSN
1522-1598
Publisher site
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Abstract

OF THE “ENDPLATE POTENTIAL” IN CURARIZED MUSCLE BERNHARD litstitute for KATZ* of Pathology, AND STEPHEN Sydney Hospital, 30, 1941) W. KUFFLER Sydney Memorial (Received publication January transmission may be divided into four successive stages: (i .) the process whereby the nerve impulse gives rise to the transmitting agents; (ii) the nature of the transmitter, and the mode of its action and subsequent inactivation; (iii) the local changes set up at the junctional region of the muscle fibre; (iv) the initiation of a propagated muscle impulse by these local changes. The present inves Itigation deals with the la ter phases of the transm ission process (problems iii and iv above) . During a state of neuromuscular block by curare, local action potentials can be recorded at the junctional region of the muscle. Their properties and their relation to the propagating impulse have been studied in detail in this and following papers. The evidence so obtained concerns primarily the initiation of the muscle impulse, but indirectly throws some light also on the transmitter problem (No. ii above). METHODS THE PROBLEM of neuro-muscular For an electrical study of neuro-muscular transmission, it would be desirable to work on a completely isolated nerve-muscle

Journal

Journal of Neurophysiology – The American Physiological Society

Published: Jul 1, 1941

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